|1.||Strongin, Alex Y: 38 articles (08/2015 - 01/2002)|
|2.||Seiki, Motoharu: 35 articles (08/2015 - 01/2002)|
|3.||Sato, Hiroshi: 18 articles (02/2015 - 03/2002)|
|4.||Annabi, Borhane: 18 articles (05/2014 - 01/2002)|
|5.||Rozanov, Dmitri V: 17 articles (09/2010 - 03/2002)|
|6.||Koshikawa, Naohiko: 15 articles (08/2015 - 08/2002)|
|7.||Golubkov, Vladislav S: 15 articles (07/2013 - 11/2004)|
|8.||Cao, Jian: 13 articles (07/2015 - 01/2002)|
|9.||Takino, Takahisa: 13 articles (12/2014 - 10/2003)|
|10.||Stack, M Sharon: 12 articles (10/2014 - 10/2002)|
01/06/2015 - "This inhibition mechanism appears to be effective in controlling active MT1-MMP in endothelial cells and at the leading edge of migratory cancer cells. "
11/05/2004 - "The functional link associating MT1-MMP with the host immune system, heretofore unrecognized, may empower tumors with an escape mechanism that contributes to the protection against the host anti-tumor immunity as well as to the survival of invading and metastatic malignant cells in the bloodstream."
12/28/2015 - "Since the processing activity of the matrix metalloproteinase MT1-MMP regulates various cellular functions such as motility, invasion, growth, differentiation and apoptosis, precise in vivo evaluation of MT1-MMP activity in cancers can provide beneficial information for both basic and clinical studies. "
01/01/2015 - "The aim of this study was to investigate possible associations between MT1-MMP expression and molecular tumor characteristics as well as morphologic features of tumor aggressiveness in a consecutive series of 79 CRC tissue samples. "
12/01/2014 - "MT1-MMP is not a good prognosticator of cancer survival: evidence from 11 studies."
|2.||Breast Neoplasms (Breast Cancer)
04/01/2006 - "Reduction of MT1-MMP from the breast cancer cells resulted in significant reduction of in vitro invasiveness and loss of response to an invasion stimulus, HGF, compared with control and wild-type cells. "
11/11/2003 - "We demonstrate significant reduction of both Id-1 and MT1-MMP expressions as well as the metastatic spread of 4T1 breast cancer cells in syngeneic BALB/c mice. "
01/01/2015 - "The aim of the present study was to analyze the expression of MT1-MMP in breast cancer and its correlation with clinicopathologic characteristics, including the survival of breast cancer patients. "
05/01/1999 - "In this study the significance of MT1-MMP expression in human breast tumors was investigated by immunocytochemical assay, and its correlation with clinicobiological features was analyzed. "
01/01/2015 - "Development of a Radiolabeled Peptide-Based Probe Targeting MT1-MMP for Breast Cancer Detection."
01/01/2007 - "The aim of this study was to investigate MT1-MMP expression in carcinoma of the larynx and analyze morphological parameters to relate the expression to CKs in pN0 lymph nodes. "
01/01/2007 - "The purpose of this study was to analyze the morphological parameters and to investigate MT1-MMP expression in laryngeal carcinoma to relate the expression to CKs in pN0 lymph nodes. "
08/01/2005 - "In this study, we examined MT1-MMP expression in 58 primary human cervical tissue specimens, including normal cervix, low-grade squamous intraepithelial lesions (LSIL), high-grade SILs (HSIL), and invasive carcinomas. "
11/01/2004 - "This study was to observe inhibitory effect of MT1-MMP antisense nucleotide on proliferation and invasive potential of human highly metastatic ovarian carcinoma cell line SW626. "
06/20/1997 - "In this study, we determined the clinico-pathologic significance of MT1-MMP expression in 68 human gastric carcinomas. "
06/07/2012 - "Further mechanistic studies revealed that MT1-MMP activates the hypoxia-inducible factor-1 (HIF-1) pathway via factor inhibiting HIF-1 (FIH-1) within niche cells, thereby inducing the transcription of HIF-responsive genes, which induce terminal hematopoietic differentiation. "
09/01/2009 - "In conclusion, hypoxia reduces MMP-2 activation and subsequent invasion of human cardiac myofibroblasts by reducing membrane expression of MT1-MMP and may delay healing after MI. "
12/15/2006 - "MMP-2, MMP-7, MT1-MMP and c-Met expressions were increased in PK8 cells under hypoxia. "
11/01/2005 - "Moreover, hypoxia led to colocalization of alpha(v)beta(3) and MMP-2, but not MT1-MMP, with phosphopaxillin in ECs. "
11/01/2015 - "Together, these data suggest that hypoxia promotes HO-8910PM ovarian cancer cell traffic through 3D matrix via Snail-mediated MT1-MMP upregulation, a possible molecular mechanism of ovarian cancer cell invasion under hypoxia. "
|5.||Vascular Diseases (Vascular Disease)
04/01/2012 - "In vivo manipulation of the expression patterns of MT1-MMP will be examined for the prevention of IH in animal models of vascular disease."
09/05/2005 - "These studies suggest that therapeutic interventions designed to target MT1-MMP could prove beneficial in a range of human vascular disease states associated with the destructive remodeling of the vessel wall extracellular matrix."
04/01/2007 - "Altogether these findings highlight a pivotal role for furin, MT1-MMP, and MMP2 in TNF-alpha-induced sphingolipid signaling, and they identify this system as a possible target to inhibit SMC proliferation in vascular diseases."
|2.||Tissue Inhibitor of Metalloproteinase-2
|4.||glucuronyl glucosamine glycan sulfate (Vessel)
|5.||Amyloid (Amyloid Fibrils)
|6.||GTP Phosphohydrolases (GTPases)
|8.||Prostaglandins F (PGF)
|9.||Messenger RNA (mRNA)
|10.||Matrix Metalloproteinase 2 (Gelatinase A)
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Drug Therapy (Chemotherapy)