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Matrix Metalloproteinase 14 (MT1-MMP)

A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the action of PROPROTEIN CONVERTASES such as FURIN. Matrix metalloproteinase 14 plays a direct role in the cleavage of proteins in the pericellular environment. In addition it can function indirectly by enzymatically activating the proprotein form of MATRIX METALLOPROTEINASE 15.
Also Known As:
MT1-MMP; Membrane-Type Matrix Metalloproteinase 1; MMP-14 Metalloproteinase; MMP-X1 Protein; MMP14 Metalloproteinase; MT-MMP-1; MT1-Matrix Metalloproteinase; Membrane-Type 1 Matrix Metalloproteinase; MMP 14 Metalloproteinase; MMP X1 Protein; MT1 Matrix Metalloproteinase; Membrane Type 1 Matrix Metalloproteinase; Membrane Type Matrix Metalloproteinase 1; Metalloproteinase 14, Matrix; Metalloproteinase, MMP-14; Metalloproteinase, MMP14; Metalloproteinase, MT1-Matrix
Networked: 845 relevant articles (13 outcomes, 124 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Strongin, Alex Y: 38 articles (08/2015 - 01/2002)
2. Seiki, Motoharu: 35 articles (08/2015 - 01/2002)
3. Sato, Hiroshi: 18 articles (02/2015 - 03/2002)
4. Annabi, Borhane: 18 articles (05/2014 - 01/2002)
5. Rozanov, Dmitri V: 17 articles (09/2010 - 03/2002)
6. Koshikawa, Naohiko: 15 articles (08/2015 - 08/2002)
7. Golubkov, Vladislav S: 15 articles (07/2013 - 11/2004)
8. Cao, Jian: 13 articles (07/2015 - 01/2002)
9. Takino, Takahisa: 13 articles (12/2014 - 10/2003)
10. Stack, M Sharon: 12 articles (10/2014 - 10/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Breast Neoplasms (Breast Cancer)
3. Carcinoma (Carcinomatosis)
4. Anoxia (Hypoxia)
5. Vascular Diseases (Vascular Disease)

Related Drugs and Biologics

1. Matrix Metalloproteinases
2. Tissue Inhibitor of Metalloproteinase-2
3. Metalloproteases (Metalloproteinases)
4. glucuronyl glucosamine glycan sulfate (Vessel)
5. Amyloid (Amyloid Fibrils)
6. GTP Phosphohydrolases (GTPases)
7. tensins (tensin)
8. Prostaglandins F (PGF)
9. Messenger RNA (mRNA)
10. Matrix Metalloproteinase 2 (Gelatinase A)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Drug Therapy (Chemotherapy)
3. Intravenous Injections
4. Aftercare (After-Treatment)
5. Adjuvant Chemotherapy