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Epithelial Sodium Channel

An AMILORIDE-sensitive sodium channel found on salt-reabsorbing EPITHELIAL CELLS that line the distal NEPHRON, the distal COLON; SALIVARY DUCTS; SWEAT GLANDS; and the LUNG. It plays a critical role in the control of sodium balance, BLOOD VOLUME, and BLOOD PRESSURE.
Also Known As:
ENaC (Epithelial Na+ Channel); ENaC alpha; ENaC beta; ENaC delta; ENaC gamma; Epithelial Amiloride-Sensitive Sodium Channel; Epithelial Sodium Channel, alpha Subunit; Epithelial Sodium Channel, beta Subunit; Epithelial Sodium Channel, delta Subunit; Epithelial Sodium Channel, gamma Subunit; SCNN1 alpha Subunit; SCNN1 beta Subunit; SCNN1 delta Subunit; SCNN1 gamma Subunit; Sodium Channel, Nonvoltage-gated 1 Protein, alpha Subunit; Sodium Channel, Nonvoltage-gated 1 Protein, beta Subunit; Sodium Channel, Nonvoltage-gated 1 Protein, delta Subunit; Sodium Channel, Nonvoltage-gated 1 Protein, gamma Subunit; Epithelial Amiloride Sensitive Sodium Channel; Sodium Channel, Epithelial; Subunit, SCNN1 alpha; Subunit, SCNN1 beta; alpha Subunit, SCNN1; beta Subunit, SCNN1; delta Subunit, SCNN1; gamma Subunit, SCNN1
Networked: 317 relevant articles (9 outcomes, 28 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Hummler, Edith: 10 articles (12/2015 - 01/2002)
2. Rossier, Bernard C: 8 articles (11/2010 - 01/2002)
3. Schild, Laurent: 7 articles (12/2010 - 01/2002)
4. Korbmacher, Christoph: 6 articles (04/2010 - 03/2004)
5. He, Jing: 5 articles (02/2015 - 11/2012)
6. Deng, Wang: 5 articles (02/2015 - 05/2011)
7. Knepper, Mark A: 5 articles (12/2007 - 05/2003)
8. Zhao, Yan: 4 articles (02/2015 - 11/2012)
9. Zhao, Dan: 4 articles (01/2015 - 06/2011)
10. Boucher, Richard C: 4 articles (06/2014 - 12/2004)

Related Diseases

1. Hypertension (High Blood Pressure)
2. Edema
3. Acute Lung Injury
4. Pulmonary Edema
5. Cystic Fibrosis (Mucoviscidosis)

Related Drugs and Biologics

1. Sodium Channel Blockers (Potassium Sparing Diuretics)
2. Adenosine Triphosphatases (ATPase)
3. Matrix Metalloproteinase 7 (Matrilysin)
4. Guanidine (Guanidine Nitrate)
5. Ibuprofen (Motrin)
6. methanesulfonic acid (methanesulfonate)
7. Sodium
8. Aldosterone
9. Ion Channels (Ion Channel)
10. Mineralocorticoids

Related Therapies and Procedures

1. Ligation
2. Therapeutics
3. Positive-Pressure Respiration (PEEP)