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Plasma Membrane Calcium-Transporting ATPases

Calcium-transporting ATPases found on the PLASMA MEMBRANE that catalyze the active transport of CALCIUM from the CYTOPLASM into the extracellular space. They play a role in maintaining a CALCIUM gradient across plasma membrane.
Also Known As:
Calcium-Transporting ATPases, Plasma Membrane; PMCA Calcium-Transporting ATPases; PMCA1 Calcium-Transporting ATPase; PMCA2 Calcium-Transporting ATPase; PMCA3 Calcium-Transporting ATPase; PMCA4 Calcium-Transporting ATPase; Plasma Membrane Ca(2+)-Pumping Adenosinetriphosphatase; Plasma Membrane Calcium ATPase; Plasma Membrane Calcium-Transporting ATPase 1; Plasma Membrane Calcium-Transporting ATPase 2; Plasma Membrane Calcium-Transporting ATPase 3; Plasma Membrane Calcium-Transporting ATPase 4; ATPase, PMCA1 Calcium-Transporting; ATPase, PMCA2 Calcium-Transporting; ATPase, PMCA3 Calcium-Transporting; ATPase, PMCA4 Calcium-Transporting; Calcium Transporting ATPases, Plasma Membrane; Calcium-Transporting ATPase, PMCA1; Calcium-Transporting ATPase, PMCA2; Calcium-Transporting ATPase, PMCA3; Calcium-Transporting ATPase, PMCA4; Calcium-Transporting ATPases, PMCA; PMCA Calcium Transporting ATPases; PMCA1 Calcium Transporting ATPase; PMCA2 Calcium Transporting ATPase; PMCA3 Calcium Transporting ATPase; PMCA4 Calcium Transporting ATPase; Plasma Membrane Calcium Transporting ATPase 1; Plasma Membrane Calcium Transporting ATPase 2; Plasma Membrane Calcium Transporting ATPase 3; Plasma Membrane Calcium Transporting ATPase 4; Plasma Membrane Calcium Transporting ATPases
Networked: 40 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Oceandy, Delvac: 6 articles (06/2022 - 12/2012)
2. Cartwright, Elizabeth J: 6 articles (10/2017 - 12/2012)
3. Neyses, Ludwig: 6 articles (10/2017 - 12/2012)
4. Elkabes, Stella: 5 articles (11/2019 - 02/2005)
5. Monteith, Gregory R: 5 articles (08/2012 - 11/2005)
6. Roberts-Thomson, Sarah J: 5 articles (08/2012 - 11/2005)
7. Mohamed, Tamer M A: 4 articles (03/2016 - 12/2012)
8. Heary, Robert F: 3 articles (11/2019 - 01/2017)
9. Ni, Li: 3 articles (11/2019 - 01/2017)
10. Couper, Kevin N: 2 articles (06/2022 - 07/2021)

Related Diseases

1. Neoplasms (Cancer)
12/01/2012 - "The plasma membrane calcium ATPase 2 (PMCA2) has been recently identified as a negative regulator of apoptosis that can play a significant role in cancer progression by conferring cells resistance to apoptosis. "
08/26/2010 - "Alterations in the expression of plasma membrane calcium ATPase (PMCA) isoforms have been reported in a variety of cancer types, including those of breast and colon, with some studies of cancer cell line differentiation identifying specific PMCA isoforms, which may be altered in some cancers. "
01/01/2023 - "Notably, the dissolution of particles outside the cells did not affect cell viability or [Ca2+]i. In contrast, internalized HAPNs dissolved more readily in cancer cells than in normal cells and inhibited the activity of plasma membrane calcium-ATPase solely in cancer cells to prevent extrusion of excessive Ca2+, hence leading to calcium overload in tumor cells. "
12/01/2018 - "The present study examined the mRNA expression levels of different isoforms of the plasma membrane calcium ATPase 2 (PMCA2) gene generated by alternative splicing at the first intracellular loop (site A) and C-terminal region (site C) in 85 human breast cancer tumor and 69 adjacent non-tumor tissues. "
04/01/2002 - "Immunohistochemistry was performed on serial cryostat sections of healthy parts of tumor nephrectomized human kidneys to study the distributions in the distal convolution of the thiazide-sensitive Na-Cl cotransporter (NCC), the beta subunit of the amiloride-sensitive epithelial Na channel (ENaC), the vasopressin-sensitive water channel aquaporin 2 (AQP2), and aquaporin 3 (AQP3), the H(+) ATPase, the Na-Ca exchanger (NCX), plasma membrane calcium-ATPase, and calbindin-D28k (CaBP). "
2. Breast Neoplasms (Breast Cancer)
3. Pain (Aches)
4. Spinal Cord Injuries (Spinal Cord Injury)
5. Hypertension (High Blood Pressure)

Related Drugs and Biologics

1. Protein Isoforms (Isoforms)
2. Calcium
3. Messenger RNA (mRNA)
4. Calbindin 1
5. Aquaporin 3
6. Aquaporin 2
7. Aquaporins (Water Channels)
8. Vasopressins (Vasopressin)
9. Proton-Translocating ATPases (ATPase, H+)
10. Amiloride (Midamor)

Related Therapies and Procedures

1. Contraception (Birth Control)