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Sarcoplasmic Reticulum Calcium-Transporting ATPases

Calcium-transporting ATPases that catalyze the active transport of CALCIUM into the SARCOPLASMIC RETICULUM vesicles from the CYTOPLASM. They are primarily found in MUSCLE CELLS and play a role in the relaxation of MUSCLES.
Also Known As:
SERCA Calcium ATPase; SERCA1 Calcium ATPase; SERCA2 Calcium ATPase; SERCA2a Calcium ATPase; SERCA3 Calcium ATPase; SR Ca(2+)-ATPase 1; SR Ca(2+)-ATPase 2; SR Ca(2+)-ATPase 3; Sarco-Endoplasmic Reticulum Ca2+-ATPase; Sarcoplasmic Reticulum Ca(2+)-ATPase; Sarcoplasmic Reticulum Calcium-Transporting ATPase 1; Sarcoplasmic Reticulum Calcium-Transporting ATPase 2; Sarcoplasmic Reticulum Calcium-Transporting ATPase 2a; Sarcoplasmic Reticulum Calcium-Transporting ATPase 3; Sarcoplasmic-Endoplasmic Reticulum Calcium ATPase 2; Sarcoplasmic-Endoplasmic Reticulum Calcium ATPase 2a; Sarcoplasmic-Endoplasmic Reticulum Calcium ATPase 3; Sarcoplasmic-endoplasmic Reticulum Calcium ATPase 1; Ca2+-ATPase, Sarco-Endoplasmic Reticulum; Calcium Transporting ATPases, Sarcoplasmic Reticulum; Reticulum Ca2+-ATPase, Sarco-Endoplasmic; Sarco Endoplasmic Reticulum Ca2+ ATPase; Sarcoplasmic Endoplasmic Reticulum Calcium ATPase 2; Sarcoplasmic Endoplasmic Reticulum Calcium ATPase 2a; Sarcoplasmic Endoplasmic Reticulum Calcium ATPase 3; Sarcoplasmic Reticulum Calcium Transporting ATPase 1; Sarcoplasmic Reticulum Calcium Transporting ATPase 2; Sarcoplasmic Reticulum Calcium Transporting ATPase 2a; Sarcoplasmic Reticulum Calcium Transporting ATPase 3; Sarcoplasmic Reticulum Calcium Transporting ATPases; Sarcoplasmic endoplasmic Reticulum Calcium ATPase 1; Calcium-Transporting ATPases, Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium ATPase
Networked: 142 relevant articles (6 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Hajjar, Roger J: 18 articles (01/2015 - 09/2005)
2. Hadri, Lahouaria: 5 articles (07/2013 - 09/2005)
3. Liang, Lifan: 4 articles (11/2014 - 02/2007)
4. Kawase, Yoshiaki: 4 articles (07/2013 - 03/2008)
5. Harding, Sian E: 3 articles (05/2015 - 06/2011)
6. Lyon, Alexander R: 3 articles (05/2015 - 06/2011)
7. Zsebo, Krisztina: 3 articles (01/2014 - 03/2008)
8. Kohlbrenner, Erik: 3 articles (08/2013 - 06/2011)
9. Lipskaia, Larissa: 3 articles (07/2013 - 09/2005)
10. Takaki, Miyako: 3 articles (06/2013 - 02/2004)

Related Diseases

1. Heart Failure
2. Myocarditis (Carditis)
3. Infection
4. Fibrosis (Cirrhosis)
10/23/2012 - "In mice subjected to pressure overload, LNA-antimiR-34 improved systolic function and attenuated lung congestion, associated with reduced cardiac fibrosis, increased angiogenesis, increased Akt activity, decreased atrial natriuretic peptide gene expression, and maintenance of sarcoplasmic reticulum Ca(2+) ATPase gene expression. "
11/01/2003 - "Sarcoplasmic reticulum Ca(2+)-ATPase activity, which influences the myocardial Ca(2+)-transient, generally is not restored to normal values in assist-device-supported hearts, but depends on a combined score of the left ventricular end-diastolic diameter, degree of ventricular fibrosis, and age of the patient at the time of assist-device implantation."
06/01/2013 - "Cardiac remodeling was characterized by quantification of dilatation, hypertrophy, fibrosis, capillary density, apoptosis, and expression of fetal genes (α/β myosin heavy chains, α-skeletal actin, periostin, and sarco/endoplasmic reticulum Ca2+-ATPase). "
02/01/2008 - "Invasive physiological measurements of cardiac function demonstrated that the 5/6 nephrectomy resulted in impairment of both active and passive left ventricular relaxation at 4 wk whereas tissue Doppler imaging detected changes in diastolic function after 6 wk. Morphologically, hearts demonstrated enlargement and progressive fibrosis, and biochemical measurements demonstrated downregulation of the sarcoplasmic reticulum calcium ATPase as well as increases in collagen-1, fibronectin, and vimentin expression. "
06/01/2005 - "LVH was also associated with myocyte enlargement, interstitial fibrosis, and enhanced expression of atrial natriuretic peptide, collagen I, collagen III, and matrix metalloproteinase-2 but suppressed expression of alpha-myosin heavy chain and sarcoplasmic reticulum Ca(2+)-ATPase. "
5. Heart Diseases (Heart Disease)

Related Drugs and Biologics

1. Endothelins (Endothelin)
2. Proteins (Proteins, Gene)
3. Calcium
4. Messenger RNA (mRNA)
5. Adenosine Triphosphatases (ATPase)
6. Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)
7. Calcium-Transporting ATPases (Ca2+ ATPase)
8. Luteolin
9. Thyroxine (Levothyroxine)
10. phospholamban

Related Therapies and Procedures

1. Cutaneous Administration
2. Stem Cell Transplantation
3. Transplantation (Transplant Recipients)
4. Nephrectomy
5. Microelectrodes