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Sarcoplasmic Reticulum Calcium-Transporting ATPases

Calcium-transporting ATPases that catalyze the active transport of CALCIUM into the SARCOPLASMIC RETICULUM vesicles from the CYTOPLASM. They are primarily found in MUSCLE CELLS and play a role in the relaxation of MUSCLES.
Also Known As:
SERCA Calcium ATPase; SERCA1 Calcium ATPase; SERCA2 Calcium ATPase; SERCA2a Calcium ATPase; SERCA3 Calcium ATPase; SR Ca(2+)-ATPase 1; SR Ca(2+)-ATPase 2; SR Ca(2+)-ATPase 3; Sarco-Endoplasmic Reticulum Ca2+-ATPase; Sarcoplasmic Reticulum Ca(2+)-ATPase; Sarcoplasmic Reticulum Calcium-Transporting ATPase 1; Sarcoplasmic Reticulum Calcium-Transporting ATPase 2; Sarcoplasmic Reticulum Calcium-Transporting ATPase 2a; Sarcoplasmic Reticulum Calcium-Transporting ATPase 3; Sarcoplasmic-Endoplasmic Reticulum Calcium ATPase 2; Sarcoplasmic-Endoplasmic Reticulum Calcium ATPase 2a; Sarcoplasmic-Endoplasmic Reticulum Calcium ATPase 3; Sarcoplasmic-endoplasmic Reticulum Calcium ATPase 1; Ca2+-ATPase, Sarco-Endoplasmic Reticulum; Calcium Transporting ATPases, Sarcoplasmic Reticulum; Reticulum Ca2+-ATPase, Sarco-Endoplasmic; Sarco Endoplasmic Reticulum Ca2+ ATPase; Sarcoplasmic Endoplasmic Reticulum Calcium ATPase 2; Sarcoplasmic Endoplasmic Reticulum Calcium ATPase 2a; Sarcoplasmic Endoplasmic Reticulum Calcium ATPase 3; Sarcoplasmic Reticulum Calcium Transporting ATPase 1; Sarcoplasmic Reticulum Calcium Transporting ATPase 2; Sarcoplasmic Reticulum Calcium Transporting ATPase 2a; Sarcoplasmic Reticulum Calcium Transporting ATPase 3; Sarcoplasmic Reticulum Calcium Transporting ATPases; Sarcoplasmic endoplasmic Reticulum Calcium ATPase 1; Calcium-Transporting ATPases, Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium ATPase
Networked: 209 relevant articles (10 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Hajjar, Roger J: 21 articles (01/2019 - 09/2005)
2. Hadri, Lahouaria: 5 articles (07/2013 - 09/2005)
3. Li, Dongye: 4 articles (01/2021 - 01/2013)
4. Hajjar, R J: 4 articles (12/2020 - 01/2000)
5. Jeong, Dongtak: 4 articles (01/2019 - 11/2014)
6. Kho, Changwon: 4 articles (01/2019 - 11/2014)
7. Oh, Jae Gyun: 4 articles (01/2019 - 11/2014)
8. Liang, Lifan: 4 articles (11/2014 - 02/2007)
9. Kawase, Yoshiaki: 4 articles (07/2013 - 03/2008)
10. Xu, Tongda: 3 articles (01/2021 - 01/2013)

Related Diseases

1. Heart Failure
2. Fibrosis (Cirrhosis)
11/01/2003 - "Sarcoplasmic reticulum Ca(2+)-ATPase activity, which influences the myocardial Ca(2+)-transient, generally is not restored to normal values in assist-device-supported hearts, but depends on a combined score of the left ventricular end-diastolic diameter, degree of ventricular fibrosis, and age of the patient at the time of assist-device implantation."
10/23/2012 - "In mice subjected to pressure overload, LNA-antimiR-34 improved systolic function and attenuated lung congestion, associated with reduced cardiac fibrosis, increased angiogenesis, increased Akt activity, decreased atrial natriuretic peptide gene expression, and maintenance of sarcoplasmic reticulum Ca(2+) ATPase gene expression. "
11/01/2022 - "In this study, we tested whether cardiac fibrosis occurred in animal models of TCEP (10 mg/kg b.w./day) administered continuously by gavage for 30 days and evaluated the specific role of sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). "
11/01/2022 - "Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA)-mediated ER stress crosstalk with autophagy is involved in tris(2-chloroethyl) phosphate stress-induced cardiac fibrosis."
02/01/2008 - "Invasive physiological measurements of cardiac function demonstrated that the 5/6 nephrectomy resulted in impairment of both active and passive left ventricular relaxation at 4 wk whereas tissue Doppler imaging detected changes in diastolic function after 6 wk. Morphologically, hearts demonstrated enlargement and progressive fibrosis, and biochemical measurements demonstrated downregulation of the sarcoplasmic reticulum calcium ATPase as well as increases in collagen-1, fibronectin, and vimentin expression. "
3. Myocarditis (Carditis)
01/01/2006 - "The present study was designed to evaluate the protective effects of Astragalus on the function of sarcoplasmic reticulum calcium ATPase (SERCA2) activity and endothelin system at acute and chronic periods of myocarditis mice induced by CVB(3) infection. "
10/01/2017 - "Upregulation of Th1-type cytokines and elevation of the Th2-type cytokines (IL-4 and IL-10), mitigation of oxidative stress, modulation of mitogen-activated protein kinase signaling pathways and increasing Sarco-endoplasmic reticulum Ca2+-ATPase levels are among the most important anti-myocarditis mechanisms for the retrieved molecules and extracts. "
12/01/1995 - "Since systolic functional impairment and subsequent recovery are frequently observed in myocarditis, we reasoned that the development of autoimmunity to cardiac sarcoplasmic reticulum calcium ATPase (SR-Ca2+ ATPase), which could interfere with intracellular calcium regulation and therefore affect myocardial contractility, should lead to immune-mediated myocarditis in experimental animals. "
03/01/1994 - "Since sarcoplasmic calcium overload is a recognized pathobiochemical finding in cardiomyopathy, we reasoned that there might be a causal relation between inhibition of sarcoplasmic calcium exclusion and pathogenesis of the disease and that immunization with sarcoplasmic reticulum calcium ATPase (SR-ATPase) or antibody specific for SR-ATPase, which can interfere with the regulation of the intracellular calcium content and the myocardial contractility, should lead to the development of cardiomyopathy and possibly myocarditis. "
4. Infections
5. Myocardial Ischemia (Ischemic Heart Diseases)

Related Drugs and Biologics

1. Endothelins (Endothelin)
2. Proteins (Proteins, Gene)
3. Atrial Natriuretic Factor (ANF)
4. Anti-Arrhythmia Agents
5. Calcium
6. Messenger RNA (mRNA)
7. Protein Isoforms (Isoforms)
8. Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)
9. Adenosine Triphosphatases (ATPase)
10. Calcium-Transporting ATPases (Ca2+ ATPase)

Related Therapies and Procedures

1. Therapeutics
2. Cutaneous Administration
3. Heart-Assist Devices
4. Drug Therapy (Chemotherapy)
5. Stem Cell Transplantation