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Inositol 1,4,5-Trisphosphate Receptors (Inositol Triphosphate Receptor)

Intracellular receptors that bind to INOSITOL 1,4,5-TRISPHOSPHATE and play an important role in its intracellular signaling. Inositol 1,4,5-trisphosphate receptors are calcium channels that release CALCIUM in response to increased levels of inositol 1,4,5-trisphosphate in the CYTOPLASM.
Also Known As:
Inositol Triphosphate Receptor; IP3 Receptor; Receptor, Inositol Triphosphate; 1,4,5-INTP Receptor; INSP3 Receptor; INSP3 Receptor Type 1; INSP3 Receptor Type 2; INSP3 Receptor Type 3; Inositol 1,4,5-trisphosphate Receptor Subtype 3; Inositol 1,4,5-trisphosphate Receptor Type 1; Inositol 1,4,5-trisphosphate Receptor Type 2; Inositol 1,4,5-trisphosphate Receptor Type 3; Inositol-1,4,5-Triphosphate Receptor; Receptor, Inositol-1,4,5-triphosphate; Type 1 Inositol 1,4,5-trisphosphate Receptor; Type 3 Inositol 1,4,5-trisphosphate Receptor; Receptor, INSP3; Receptor, IP3; Triphosphate Receptor, Inositol; Inositol 1,4,5-Triphosphate Receptors
Networked: 87 relevant articles (0 outcomes, 9 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Foskett, J Kevin: 4 articles (10/2015 - 06/2008)
2. Mikoshiba, Katsuhiko: 4 articles (01/2015 - 09/2003)
3. Mak, Don-On Daniel: 3 articles (10/2015 - 01/2010)
4. Cheung, King-Ho: 3 articles (10/2015 - 06/2008)
5. Liu, Pei: 3 articles (01/2011 - 10/2004)
6. Boehning, Darren: 2 articles (03/2015 - 05/2008)
7. Müller, Marioly: 2 articles (05/2014 - 06/2008)
8. Subramanian, Manivannan: 2 articles (05/2013 - 01/2013)
9. Hasan, Gaiti: 2 articles (05/2013 - 01/2013)
10. Singleton, Andrew: 2 articles (05/2011 - 05/2010)

Related Diseases

1. Anoxia (Hypoxia)
2. Breast Neoplasms (Breast Cancer)
11/01/2013 - "Studies from our laboratory have shown that type 3 IP3 receptor (IP3R3) and voltage- and Ca(2+)-dependent K(+) channels BKCa channels are involved in human breast cancer cell proliferation. "
11/01/2013 - "Molecular interaction and functional coupling between type 3 inositol 1,4,5-trisphosphate receptor and BKCa channel stimulate breast cancer cell proliferation."
07/01/2005 - "The aim of this study was to establish the type(s) of inositol 1,4,5-trisphosphate receptors (IP3Rs) in T47D breast cancer cells that regulate intracellular calcium (Ca2+) and whether they interact with cyclin (Cy), an important regulator of cyclin-dependent kinases (cdk), during cell cycle progression. "
12/01/2013 - "Actein alters the activity of the ER IP3 receptor and Na,K-ATPase, induces calcium release and modulates the NF-κB and MEK pathways and may be worthwhile to explore to prevent and treat breast cancer."
10/15/2004 - "The cDNA-oligoarray analysis and reverse transcription-PCR verification indicated common changes in gene expression in methionine-dependent cell lines to include up-regulation/induction of cyclin D1, mitotic arrest deficient (MAD)1, p21, growth arrest and DNA-damage-inducible (GADD)45 alpha, GADD45 gamma, GADD34, breast cancer (BRCA)1, 14-3-3sigma, B-cell CLL/lymphoma (BCL)1, transforming growth factor (TGF)-beta, TGF-beta-induced early response (TIEG), SMAD5, SMAD7, SMAD2, insulin-like growth factor binding protein (IGFBP7), IGF-R2, vascular endothelial growth factor (VEGF), TNF-related apoptosis-inducing ligand (TRAIL), TNF-alpha converting enzyme (TACE), TRAIL receptor (TRAIL-R)2, TNFR-related death receptor (DR)6, TRAF interacting protein (I-TRAF), IL-6, MDA7, IL-1B convertase (ICE)-gamma, delta and epsilon, IRF1, IRF5, IRF7, interferon (IFN)-gamma and receptor components, ISG15, p65-NF-kappaB, JUN-B, positive cofactor (PC)4, C/ERB-beta, inositol triphosphate receptor I, and methionine adenosyltransferase II. On the other hand, cyclins A1, A2, B1 and B2, cell division cycle (CDC)2 and its kinase, CDC25 A and B, budding uninhibited by benzimidazoles (BUB)1 and 3, MAD2, CDC28 protein kinase (CKS)1 and 2, neuroepithelial cell transforming gene (NET)1, activator of S-phase kinase (ASK), CDC14B phosphatase, BCL2, TGF-beta activated kinase (TAK)1, TAB1, c-FOS, DNA topoisomerase II, DNA polymerase alpha, dihydrofolate reductase, thymidine kinase, stathmin, and MAP4 were down-regulated. "
3. Alzheimer Disease (Alzheimer's Disease)
4. Lymphoma (Lymphomas)
5. Ischemia

Related Drugs and Biologics

1. Inositol (Myoinositol)
2. Inositol 1,4,5-Trisphosphate
3. Calcium
4. Messenger RNA (mRNA)
5. Ankyrins
6. Cyclins
7. Ryanodine
8. Cyclin-Dependent Kinases (cdk Proteins)
9. Proteins (Proteins, Gene)
10. Phosphopyruvate Hydratase (Enolase)