DEAD-box RNA Helicases

A large family of RNA helicases that share a common protein motif with the single letter amino acid sequence D-E-A-D (Asp-Glu-Ala-Asp). In addition to RNA helicase activity, members of the DEAD-box family participate in other aspects of RNA metabolism and regulation of RNA function.

Also Known As:

Networked: 117 relevant articles (0 outcomes, 10 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fuller-Pace, Frances V: 5 articles (01/2013 - 06/2008)
2.	Liu, Zhi-Ren: 4 articles (01/2021 - 06/2005)
3.	Clark, Emma L: 3 articles (01/2013 - 06/2008)
4.	Robson, Craig N: 3 articles (01/2013 - 06/2008)
5.	Zhang, Hao: 2 articles (07/2022 - 10/2016)
6.	Ghosh, Mrinal K: 2 articles (01/2022 - 07/2019)
7.	Ali, Mohamed A M: 2 articles (05/2021 - 11/2017)
8.	Raman, Venu: 2 articles (01/2021 - 09/2015)
9.	Vesuna, Farhad: 2 articles (01/2021 - 09/2015)
10.	Wang, Rui: 2 articles (01/2019 - 09/2012)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "DEAD-box helicase 27 (DDX27) is a member of the DEAD-box RNA helicase family, and there have been only a few studies on DDX27 function in cancer cells. " 01/01/2007 - "Here we study the role of one putative DEAD-box RNA helicase, MrDb (DDX18), in tumor cells. " 07/01/2023 - "Therefore, in this review, we aim to illustrate a comprehensive overview of DEAD-box RNA helicases especially p68 by focusing on their multifaceted roles in different cancers and the various signaling pathways affected by them. " 07/01/2023 - "DEAD-box RNA helicases with special reference to p68: Unwinding their biology, versatility, and therapeutic opportunity in cancer." 01/05/2023 - "The DEAD-box RNA helicase 41 gene, DDX41, is frequently mutated in hereditary myeloid neoplasms, identified in 2% of entire patients with AML/MDS. "
2.	Genomic Instability 01/01/2021 - "DEAD-Box RNA Helicases and Genome Stability." 01/01/2021 - "Finally, we summarized the pathological and therapeutic relationship between DEAD-box RNA helicases and cancer with respect to their novel role in genome stability." 01/01/2021 - "Current studies have provided insight into the connection between genomic stability and several DEAD-box RNA helicase family proteins including DDX1, DDX3X, DDX5, DDX19, DDX21, DDX39B, and DDX41. " 09/01/2020 - "R-loops are three-stranded structures consisting of a DNA/RNA hybrid and a displaced DNA strand. The regulatory factors required to process this fundamental genetic structure near double-strand DNA breaks (DSBs) are not well understood. We previously reported that cellular depletion of the ATP-dependent DEAD box RNA helicase DDX5 increases R-loops genome-wide causing genomic instability. In this study, we define a pivotal role for DDX5 in clearing R-loops at or near DSBs enabling proper DNA repair to avoid aberrations such as chromosomal deletions. "
3.	Carcinogenesis 12/01/2020 - "DDX3X (Xp11.4) encodes the DEAD box RNA helicase that plays an important role in gene regulation, apoptosis, and oncogenesis. " 01/01/2017 - "The DEAD-box RNA helicase DDX3 plays divergent roles in tumorigenesis, however, its function in mitosis is unclear. " 01/01/2016 - "DEAD box RNA helicases: crucial regulators of gene expression and oncogenesis." 10/01/2010 - "Also, acetylation of p72, but not of p68 RNA helicase, enhanced p53-dependent activation of the MDM2 promoter, pointing at another mechanism of how p72 acetylation may facilitate carcinogenesis by boosting the negative p53-MDM2 feedback loop. " 07/27/2019 - "In this study, we aim to discern the molecular mechanism of how an RNA helicase, p68 deploys a major oncogenic signaling pathway, Wnt/ β-catenin to regulate the expression of RelA, an indispensable component of NF-κB signaling pathway towards driving colon carcinogenesis. "
4.	Infections 01/01/2017 - "In this study, we reported that DDX25, a DEAD-box RNA helicase, plays a proviral role in DENV infection. " 10/01/2022 - "Identification and characterization of DEAD-box RNA helicase DDX3 in rainbow trout (Oncorhynchus mykiss) and its relationship with infectious hematopoietic necrosis virus infection." 01/01/2008 - "OsBIRH1, a DEAD-box RNA helicase with functions in modulating defence responses against pathogen infection and oxidative stress." 11/01/2022 - "Amongst these, the three DEAD-box RNA helicases AAEL004419/Dhx15, AAEL008728, and AAEL004859 also acted as antiviral factors in dengue and CHIKV infections. " 02/01/2023 - "Some chloroplast proteins, including translation initiation factor [eIF(iso)4E] and 75 DEAD-box RNA helicase RH8, help viruses fulfill their infection cycle in plants. "
5.	Medulloblastoma 01/01/2021 - "Medulloblastoma-associated mutations in the DEAD-box RNA helicase DDX3X/DED1 cause specific defects in translation." 05/08/2015 - "The DEAD-box RNA helicase DDX3X is frequently mutated in pediatric medulloblastoma. " 01/01/2021 - "Medulloblastoma is the most common pediatric brain cancer, and sequencing studies identified frequent mutations in DDX3X, a DEAD-box RNA helicase primarily implicated in translation. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	RNA (Ribonucleic Acid)
3.	Catenins
4.	Adenosine Triphosphate (ATP)
5.	MicroRNAs (MicroRNA)
6.	A-Form DNA (A-DNA)
7.	DNA (Deoxyribonucleic Acid)
8.	Transcription Factors (Transcription Factor)
9.	Messenger RNA (mRNA)
10.	Androgen Receptors (Androgen Receptor)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy