|1.||Bohr, Vilhelm A: 18 articles (11/2014 - 11/2003)|
|2.||Brosh, Robert M: 15 articles (11/2015 - 01/2004)|
|3.||Sharma, Sudha: 12 articles (06/2015 - 05/2005)|
|4.||Hickson, Ian D: 10 articles (01/2013 - 11/2002)|
|5.||Croteau, Deborah L: 9 articles (11/2014 - 09/2009)|
|6.||Vindigni, Alessandro: 9 articles (07/2013 - 01/2004)|
|7.||Popuri, Venkateswarlu: 6 articles (01/2014 - 02/2007)|
|8.||Furuichi, Yasuhiro: 6 articles (05/2012 - 08/2004)|
|9.||Shimamoto, Akira: 6 articles (06/2008 - 08/2004)|
|10.||Hickson, I D: 6 articles (09/2007 - 02/2000)|
06/01/2007 - "A number of studies have described interactions of RecQ helicases with topoisomerases and it has been proposed that this cooperation may be essential for cell viability and the avoidance of cancer development in human cells."
05/01/2014 - "Mice deficient in RecQL5, one of five RecQ helicases, show a cancer predisposition phenotype, suggesting that RecQL5 plays a tumor suppressor role. "
01/01/2014 - "The "tumor suppressor" role of RECQL4 and the other RECQ helicases is an area of active investigation. "
08/01/2012 - "Humans have five different RecQ helicases and defects in three of them cause autosomal recessive diseases leading to various kinds of cancer predisposition and/or aging phenotypes. "
01/01/2011 - "In future, RecQ helicases are anticipated to be additional molecular targets for cancer chemotherapeutics."
|2.||Werner Syndrome (Werner's Syndrome)
07/01/2010 - "Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by null mutations at the WRN locus, which codes for a member of the RecQ family of DNA helicases. "
01/01/2008 - "Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases."
09/07/2007 - "We show here that the Werner syndrome protein (WRN), a member of the RecQ family of DNA helicases, associates with NEIL1 in the early damage-sensing step of base excision repair. "
09/15/2005 - "Werner syndrome is an autosomal recessive accelerated-aging disorder caused by a defect in the WRN gene, which encodes a member of the RecQ family of DNA helicases with an exonuclease activity. "
02/25/2005 - "The prototypic example of the former is the Werner syndrome, a condition caused by mutations of the RecQ family of DNA helicases. "
|3.||Chromosomal Instability (Chromosome Stability)
04/15/2008 - "Collectively, these studies provide the first evidence for an important role of RECQ1 to confer chromosomal stability that is unique from that of other RecQ helicases and suggest its potential involvement in tumorigenesis."
03/01/2007 - "RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability."
02/01/2007 - "RecQ helicases are essential for the maintenance of chromosome stability. "
09/01/2009 - "Genetic defects in three of the five human RecQ helicases, BLM, WRN and RECQ4, give rise to defined syndromes associated with cancer predisposition, some features of premature ageing and chromosomal instability. "
12/01/2009 - "RecQ helicases maintain chromosome stability by resolving several highly specific DNA structures. "
08/14/2015 - "Fission yeast Rqh1 is a member of RecQ helicases family which has essential roles in the maintenance of genomic stability and regulation of homologous recombination. "
01/01/2015 - "Like other RECQ helicases, WRN/RECQL2 plays a crucial role in DNA replication and the maintenance of genome stability. "
08/01/2014 - "Together, our data indicate that RECQL4 participates in DNA replication rather than genome stability and identify RECQL4 as a regulator of hematopoiesis with a nonredundant role compared with other RecQ helicases. "
02/01/2014 - "RecQ helicases are critical for the maintenance of genomic stability. "
01/01/2014 - "Future research goals in this field include a better understanding of the division of labor among the human RecQ helicases and learning how human RecQ helicases collaborate and cooperate to enhance genome stability. "
09/01/2007 - "Defects in RecQ helicases result in premature aging phenotypes in both yeasts and humans, which appear to be promoted by replicative stress. "
01/01/2007 - "Human premature aging, DNA repair and RecQ helicases."
09/15/2003 - "RecQ helicases: suppressors of tumorigenesis and premature aging."
11/01/2012 - "RecQL4, one of the five human RecQ helicases, is crucial for genomic stability and RecQL4 when mutated leads to premature aging phenotypes in humans. "
03/02/2010 - "Defects in three of the RecQ helicases, RecQ4, BLM, and WRN, cause human pathologies linked with cancer predisposition and premature aging. "
|1.||DNA (Deoxyribonucleic Acid)
|2.||DNA Glycosylases (DNA Glycosylase)
|3.||A-Form DNA (A-DNA)
|4.||Deoxyribonuclease (Pyrimidine Dimer)
|9.||Proteins (Proteins, Gene)
|2.||Drug Therapy (Chemotherapy)