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Apoptosomes (Apoptosome)

Multimeric protein complexes formed in the CYTOSOL that play a role in the activation of APOPTOSIS. They can occur when MITOCHONDRIA become damaged due to cell stress and release CYTOCHROME C. Cytosolic cytochrome C associates with APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 to form the apoptosomal protein complex. The apoptosome signals apoptosis by binding to and activating specific INITIATOR CASPASES such as CASPASE 9.
Also Known As:
Apoptosome; Apoptosomal Protein Complex; Complex, Apoptosomal Protein; Protein Complex, Apoptosomal
Networked: 72 relevant articles (1 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Krepela, Evzen: 4 articles (05/2014 - 02/2004)
2. Kornbluth, Sally: 3 articles (09/2008 - 02/2006)
3. Cecconi, Francesco: 3 articles (04/2008 - 09/2006)
4. Cain, Kelvin: 3 articles (11/2003 - 02/2003)
5. Moravcikova, Erika: 2 articles (05/2014 - 06/2012)
6. Prochazka, Jan: 2 articles (05/2014 - 06/2012)
7. Benkova, Kamila: 2 articles (05/2014 - 06/2012)
8. Prehn, J H M: 2 articles (04/2012 - 12/2008)
9. Tan, Lijun: 2 articles (02/2011 - 02/2002)
10. Liu, J Rebecca: 2 articles (02/2011 - 02/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Colorectal Neoplasms (Colorectal Cancer)
3. T-Cell Leukemia (Leukemia, T Cell)
4. Dementia (Dementias)
5. Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)

Related Drugs and Biologics

1. Histone Deacetylase Inhibitors
2. LBH589
3. LAQ824
4. Proteins (Proteins, Gene)
5. Caspase 3 (Caspase-3)
6. Caspases
7. Paraffin
8. Nucleotides
9. Formaldehyde (Formol)
10. Diclofenac (SR 38)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Aftercare (After-Treatment)