|1.||Krepela, Evzen: 4 articles (05/2014 - 02/2004)|
|2.||Kornbluth, Sally: 3 articles (09/2008 - 02/2006)|
|3.||Cecconi, Francesco: 3 articles (04/2008 - 09/2006)|
|4.||Cain, Kelvin: 3 articles (11/2003 - 02/2003)|
|5.||Moravcikova, Erika: 2 articles (05/2014 - 06/2012)|
|6.||Prochazka, Jan: 2 articles (05/2014 - 06/2012)|
|7.||Benkova, Kamila: 2 articles (05/2014 - 06/2012)|
|8.||Prehn, J H M: 2 articles (04/2012 - 12/2008)|
|9.||Tan, Lijun: 2 articles (02/2011 - 02/2002)|
|10.||Liu, J Rebecca: 2 articles (02/2011 - 02/2002)|
05/01/2006 - "In this review, we describe knockout and knockin studies of apoptosome components, elegant structural and biochemical experiments, and analyses of the apoptosome in various cancers and other disease states, all of which have provided new insight into this critical locus of apoptotic control."
01/01/2013 - "Data demonstrate that nsPEFs can bypass cancer mutations that evade apoptosis through mechanisms at either the DISC or the apoptosome. "
01/15/2009 - "We detail the evidence that loss-of-function of the apoptosome pathway may contribute to the development of specific cancers. "
01/15/2009 - "Targeting the apoptosome for cancer therapy."
03/01/2008 - "We discuss how the apoptosome is regulated in normal and disease states, and how targeting of apoptosome-dependent, post-mitochondrial stages of apoptosis may serve as a rational approach to cancer treatment."
|2.||Colorectal Neoplasms (Colorectal Cancer)
12/01/2011 - "Chemopreventive effects of non-steroidal anti-inflammatory drugs in early neoplasm of experimental colorectal cancer: an apoptosome study."
04/24/2012 - "Apoptosome-dependent caspase activation proteins as prognostic markers in Stage II and III colorectal cancer."
04/24/2012 - "Survival analysis indicated that of the apoptosome-associated proteins examined here, Pro-caspase 3 and APAF1 have potential clinical utility as predictive markers in Stage II and III colorectal cancer, respectively. "
04/24/2012 - "Here we performed a systematic analysis of the immunohistochemical expression of the key proteins involved in apoptosome-dependent caspase activation (APAF1, Pro-caspases 9 and 3, SMAC, and XIAP) in a cohort of Stage II and III colorectal cancer patients from a Phase III trial of adjuvant 5-fluorouracil-based chemotherapy vs postoperative observation alone. "
|3.||T-Cell Leukemia (Leukemia, T Cell)
07/07/2014 - "Immunohistochemical localization of apoptosome-related proteins in Lewy bodies in Parkinson's disease and dementia with Lewy bodies."
07/07/2014 - "To investigate the role of the apoptosome in patients with Parkinson׳s disease (PD), we performed immunohistochemical studies on apoptosome-related proteins in formalin-fixed, paraffin-embedded sections from 8 normal subjects, 10 patients with PD and 5 patients with dementia with Lewy bodies (DLB). "
|5.||Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
05/01/2014 - "To gain insight into the functional status of the apoptosome apparatus in non-small cell lung carcinoma (NSCLC), we studied its sensitivity to activation, the assembly of apoptosome complexes and stability of their precursors, and the importance of X-linked inhibitor of apoptosis (XIAP) in the regulation of apoptosome activity, using cell-free cytosols from NSCLC cell lines and NSCLC tumours and lungs from 62 surgically treated patients. "
05/01/2014 - "Differential sensitivity to apoptosome apparatus activation in non-small cell lung carcinoma and the lung."
06/01/2012 - "The Apaf-1 interacting protein (APIP) and the uveal autoantigen with coiled coil domains and ankyrin repeats (UACA) belong to endogenous regulators of the apoptosome apparatus, but their role in tumourigenesis and progression of non-small cell lung carcinoma (NSCLC) is not known. "
01/01/2006 - "Tumour cells killing by cytotoxic therapies largely depends on triggering the intrinsic apoptosome-mediated caspase activation pathway but it had never been evaluated whether the expression of transcripts encoding the core components of apoptosome pathway is altered in non-small cell lung carcinoma (NSCLC). "
01/01/2006 - "Expression of apoptosome pathway-related transcripts in non-small cell lung cancer."
|1.||Histone Deacetylase Inhibitors
|4.||Proteins (Proteins, Gene)
|5.||Caspase 3 (Caspase-3)
|10.||Diclofenac (SR 38)
|1.||Drug Therapy (Chemotherapy)