HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Apoptosomes (Apoptosome)

Multimeric protein complexes formed in the CYTOSOL that play a role in the activation of APOPTOSIS. They can occur when MITOCHONDRIA become damaged due to cell stress and release CYTOCHROME C. Cytosolic cytochrome C associates with APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 to form the apoptosomal protein complex. The apoptosome signals apoptosis by binding to and activating specific INITIATOR CASPASES such as CASPASE 9.
Also Known As:
Apoptosome; Apoptosomal Protein Complex; Complex, Apoptosomal Protein; Protein Complex, Apoptosomal
Networked: 85 relevant articles (1 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Krepela, Evzen: 4 articles (05/2014 - 02/2004)
2. Kornbluth, Sally: 3 articles (09/2008 - 02/2006)
3. Cecconi, Francesco: 3 articles (04/2008 - 09/2006)
4. Cain, Kelvin: 3 articles (11/2003 - 02/2003)
5. Rehm, Markus: 2 articles (10/2020 - 09/2014)
6. Chandra, Dhyan: 2 articles (01/2020 - 01/2019)
7. Kumar, Rahul: 2 articles (01/2020 - 01/2019)
8. O'Malley, Jordan: 2 articles (01/2020 - 01/2019)
9. Wang, Jianmin: 2 articles (01/2020 - 01/2019)
10. Yadav, Neelu: 2 articles (01/2020 - 01/2019)

Related Diseases

1. Neoplasms (Cancer)
2. Colorectal Neoplasms (Colorectal Cancer)
3. Hepatocellular Carcinoma (Hepatoma)
4. Mitochondrial Diseases (Mitochondrial Disease)
5. Multiple System Atrophy

Related Drugs and Biologics

1. Death Domain Receptors
2. Histone Deacetylase Inhibitors
3. Panobinostat
4. LAQ824
5. Proteins (Proteins, Gene)
6. Caspases
7. Cytochromes c (Cytochrome c)
8. Paraffin
9. Formaldehyde (Formol)
10. Caspase 3 (Caspase-3)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Therapeutics
3. Aftercare (After-Treatment)
4. Liver Transplantation