Apoptotic Protease-Activating Factor 1

A CARD signaling adaptor protein characterized by an N-terminal CARD DOMAIN and C-terminal WD40 REPEATS. It plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY) and binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX which activates INITIATOR CASPASES such as CASPASE 9.

Also Known As:

Networked: 52 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Tang, You: 2 articles (05/2022 - 08/2020)
2.	Teng, Xiaohua: 2 articles (05/2022 - 08/2020)
3.	Zhang, Jingyang: 2 articles (05/2022 - 08/2020)
4.	Cui, Jiawen: 1 article (05/2022)
5.	Lin, Xu: 1 article (05/2022)
6.	Wang, Yueyang: 1 article (05/2022)
7.	Campbell, Kirsteen J: 1 article (01/2022)
8.	Winder, Matthew L: 1 article (01/2022)
9.	Bonsembiante, Federico: 1 article (09/2021)
10.	Bucci, Massimo: 1 article (09/2021)

Related Diseases

1.	Neoplasms (Cancer) 09/04/2020 - "In this study, we show that LINC00473 (LNC473) exerted its functions as a tumor suppressor in promoting apoptotic protease-activating factor 1 (APAF1) IRES activity through competitively sponging miR574-5p and miR15b-5p in CRC initiation and pathogenesis. " 07/01/2020 - "Apoptotic peptidase activating factor 1 (APAF-1) is essential regulator of apoptosis and inactivation by DNA methylation is common event in numerous cancer types. " 02/01/2009 - "[Apoptotic protease activating factor 1 inducing apoptosis and related anti-tumor therapy -- review]." 01/01/2023 - "The Apoptotic protease activating factor 1 (Apaf-1) protein, as one of the factors involved in the activation of the mitochondrial apoptotic pathway, plays an important role in cancer biology. " 01/01/2019 - "They are simplified parasitic cnidarians that universally lack major genes implicated in cancer progression including all genes with Caspase and BCL2 domains as well as any p53 and apoptotic protease activating factor - 1 (Apaf-1) homologs, suggesting the disruption of main apoptotic pathways in their early evolutionary history. "
2.	B-Cell Lymphoma (Lymphoma, B Cell) 01/01/2020 - "In vitro PDA treatment could dose-dependently induce the expression of the transcription factor FOXM1 (forkhead box M1) and several proapoptotic genes, such as PUMA (p53-upregulated modulator of apoptosis), BAX (B-cell/lymphoma 2-associated X) and APAF1 (apoptotic peptidase activating factor 1), thereby causing apoptosis. " 06/01/2017 - "Further, B-cell lymphoma 2-associated X protein ( = 0.02) and apoptotic protease activating factor 1 ( = 0.01) proteins were increased by HS compared to TN and PFTN. " 03/01/2012 - "Mammalian B-cell lymphoma 2 (Bcl-2) inhibits apoptosis by preventing the release of the Apaf-1 (apoptotic protease-activating factor 1) activator cytochrome c from mitochondria. " 02/01/2015 - "A total of 400 μg/ml PLCSB significantly induced apoptosis in HCT-116 cells (P<0.05) via the upregulation Bax, p53, p21, apoptotic protease activating factor 1, caspase-3, -8, and -9, as well as Fas and the downregulation of B-cell lymphoma 2 (Bcl-2), Bcl-extra large and Fas ligand (L). " 08/01/2019 - "This study reports the molecular mechanism of apoptotic cell death through the upregulation of Bax (Bcl-2 family activating protein-X), Bad, APAF-1 (apoptotic protease activating factor-1), Cyt-c, and caspase-3/9 and the downregulation of Bcl-2 (B-cell lymphoma 2) in rpie-5-treated cancer cells. "
3.	Lymphoma (Lymphomas) 08/01/2017 - "Further mechanistic investigations revealed that the induction of apoptosis was associated with increased generation of ROS, reduced ∆Ψm, and upregulation of B‑cell lymphoma 2‑associated X protein, cytochrome c, caspase‑9, apoptotic protease activating factor 1 and caspase‑3. " 08/01/2018 - "The increased intracellular level of ROS appeared to induce the activation of p53 and elevate the B‑cell lymphoma 2 (Bcl‑2)‑associated X protein/Bcl‑2 ratio, which modulates ΔΨm and triggers the release of cytochrome c, and may increase the activities of apoptotic protease activating factor 1, caspase‑3, ‑8 and ‑9 to further trigger the destruction of structural and specific proteins and thereby cell apoptosis. " 02/01/2018 - "Reverse transcription‑quantitative polymerase chain reaction and western blot assay were performed to examine the expression levels of proteins, including HSP20, B‑cell lymphoma 2 (Bcl‑2), cytochrome complex (Cyt‑c), apoptotic protease activating factor 1 (APAF1), caspase‑9 andcaspase‑3, and the phosphorylation of Akt (p‑Akt) in H9C2 cells. " 03/01/2019 - "Signal transduction mechanism studies indicated that exposure to Cu-NPs activated caspases 3, 8, and 9 and BH3 interacting domain death agonist (tBid), reduced B cell leukemia/lymphoma 2 (Bcl-2) expression, and increased the expression of apoptotic peptidase activating factor 1 (Apaf-1), BCL2-associated X, apoptosis regulator (Bax), and cytochrome c. "
4.	AIDS-Related Complex (ARC) 02/01/2008 - "Three dimensional models of NB-ARC domains in five different proteins were constructed based on the recently published crystal structure of the apoptotic protease activating factor 1, of which two are for tomato species, one each for flax, Arabidopsis, and nematode. " 06/25/2018 - "In this study, we indicated the disease resistance genes (proteins) that play an important role in defense against pathogens in Arabidopsis thaliana (thale cress) and Cucumis sativus (cucumber), by searches based on the conserved protein domains, NB-ARC (a nucleotide-binding adaptor shared by the apoptotic protease-activating factor-1, plant resistance proteins, and Caenorhabditis elegans death-4 protein) and C-terminal leucine-rich repeat (LRR), in the nucleotide-binding domain and LRR (NLR) proteins. "
5.	Disease Resistance 06/25/2018 - "In this study, we indicated the disease resistance genes (proteins) that play an important role in defense against pathogens in Arabidopsis thaliana (thale cress) and Cucumis sativus (cucumber), by searches based on the conserved protein domains, NB-ARC (a nucleotide-binding adaptor shared by the apoptotic protease-activating factor-1, plant resistance proteins, and Caenorhabditis elegans death-4 protein) and C-terminal leucine-rich repeat (LRR), in the nucleotide-binding domain and LRR (NLR) proteins. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Cytochromes c (Cytochrome c)
3.	Caspase 3 (Caspase-3)
4.	Caspases
5.	Nucleotides
6.	Leucine (L-Leucine)
7.	Cyclin B1
8.	Luteolin
9.	NLR Proteins
10.	2'-deoxyadenosine

Related Therapies and Procedures

1.	Therapeutics