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Apoptotic Protease-Activating Factor 1

A CARD signaling adaptor protein that plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY). It binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX and activates INITIATOR CASPASES such as CASPASE 9.
Also Known As:
Apaf-1 Protease-Activating Factor; Apaf 1 Protease Activating Factor; Apoptotic Protease Activating Factor 1; Protease-Activating Factor, Apaf-1
Networked: 16 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. García-Flórez, Luis Joaquín: 1 article (03/2015)
2. Barneo-Serra, Luis: 1 article (03/2015)
3. Martínez-Alonso, Carmen: 1 article (03/2015)
4. Frunza, Ana Madalina: 1 article (03/2015)
5. Fresno-Forcelledo, Manuel Florentino: 1 article (03/2015)
6. Gómez-Álvarez, Guillermo: 1 article (03/2015)
7. Yu, Haixiang: 1 article (11/2014)
8. Figg, Nichola: 1 article (11/2014)
9. Lam, Brian: 1 article (11/2014)
10. Littlewood, Trevor: 1 article (11/2014)

Related Diseases

1. Neoplasms (Cancer)
02/01/2009 - "[Apoptotic protease activating factor 1 inducing apoptosis and related anti-tumor therapy -- review]."
01/15/2007 - "Furthermore, we showed that the observed synergistic tumor suppression by FUS1 and p53 concurred with the FUS1-mediated down-regulation of murine double minute-2 (MDM2) expression, the accumulation and stabilization of p53 protein, as well as the activation of the apoptotic protease-activating factor 1 (Apaf-1)-dependent apoptotic pathway in human NSCLC cells. "
03/01/2015 - "Regarding predictive markers of response, there was significant correlation between the expression of B-cell lymphoma 2 (P = 0.005), β-catenin (P = 0.03), vascular endothelial growth factor (P = 0.048) and apoptotic protease activating factor 1 (P = 0.03), tumor differentiation grade (P < 0.001), and response in the univariate analysis. "
03/01/2010 - "We sought to investigate CpG-island methylation profiling of apoptotic genes apoptotic protease activating factor 1, caspase 8, death-associated protein kinase (DAPK), tumor necrosis factor receptor superfamily member 6 (FAS), Survivin, and tumor necrosis factor-related apoptosis-inducing ligand receptor-1 and its role in resistance to therapy in cervical cancer (CXCA). "
02/15/2013 - "Primary bladder tumors from 212 cancer registry patients (median follow-up, 13.2 years) were immunohistochemically profiled for Bax, caspase-3, apoptotic protease-activating factor 1 (Apaf-1), Bcl-2, p53, p21, cyclooxygenase-2, vascular endothelial growth factor, and E-cadherin alterations. "
2. B-Cell Lymphoma (Lymphoma, B Cell)
3. Inflammation
4. Atherosclerosis
5. B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)

Related Drugs and Biologics

1. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2. Caspase 3 (Caspase-3)
3. CD95 Antigens (fas Receptor)
4. Cadherins (E-Cadherin)
5. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6. Proteins (Proteins, Gene)
7. Caspase 9
8. Fas-Associated Death Domain Protein (Fas-Associating Protein with Death Domain)
9. Caspase 8 (Caspase-8)
10. Cyclooxygenase 2 (Cyclooxygenase-2)