Nod2 Signaling Adaptor Protein

A NOD signaling adaptor protein that contains two C-terminal leucine-rich domains which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. The protein plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the nucleotide oligomerization domain 2 protein have been associated with increased susceptibility to CROHN DISEASE.

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Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fraser, Alan: 1 article (12/2008)
2.	Hong, Jiwon: 1 article (12/2008)
3.	Krissansen, Geoffrey Wayne: 1 article (12/2008)
4.	Leung, Euphemia: 1 article (12/2008)
5.	Folwaczny, Christian: 1 article (08/2004)
6.	Folwaczny, Matthias: 1 article (08/2004)
7.	Glas, Jürgen: 1 article (08/2004)
8.	Mauermann, Daniel: 1 article (08/2004)
9.	Török, Helga-Paula: 1 article (08/2004)
10.	Cho, Judy H: 1 article (01/2003)

Related Diseases

1.	Periodontitis 08/01/2004 - "The prevalence of the 3020insC mutation of the NOD2/CARD15 protein in patients with periodontitis was 1.9% (three of 160) and that for the control group was 2.0% (five of 244) (P = 0.942). "
2.	Crohn Disease (Crohn's Disease) 12/01/2008 - "CARD15 genes carrying the 3020insC frameshift polymorphism encode a truncated CARD15 protein that is unresponsive to bacterial muramyl dipeptide, and are strongly associated with increased susceptibility to Crohn's disease (CD). "
3.	Bacterial Infections (Bacterial Infection) 01/01/2003 - "The affected gene codes for the NOD2/CARD15 protein, which is involved in the immune system's response to bacterial infection. "

Related Drugs and Biologics

1.	Acetylmuramyl-Alanyl-Isoglutamine