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Nod2 Signaling Adaptor Protein

A NOD signaling adaptor protein that contains two C-terminal leucine-rich domains which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. The protein plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the nucleotide oligomerization domain 2 protein have been associated with increased susceptibility to CROHN DISEASE.
Also Known As:
CARD15 Protein; Caspase Recruitment Domain Protein 15; Nucleotide Oligomerization Domain 2 Protein
Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Fraser, Alan: 1 article (12/2008)
2. Krissansen, Geoffrey Wayne: 1 article (12/2008)
3. Hong, Jiwon: 1 article (12/2008)
4. Leung, Euphemia: 1 article (12/2008)
5. Török, Helga-Paula: 1 article (08/2004)
6. Folwaczny, Matthias: 1 article (08/2004)
7. Mauermann, Daniel: 1 article (08/2004)
8. Glas, Jürgen: 1 article (08/2004)
9. Folwaczny, Christian: 1 article (08/2004)
10. Cho, Judy H: 1 article (01/2003)

Related Diseases

1. Periodontitis
2. Crohn Disease (Crohn's Disease)
3. Bacterial Infections (Bacterial Infection)

Related Drugs and Biologics

1. Acetylmuramyl-Alanyl-Isoglutamine