Nod2 Signaling Adaptor Protein
A NOD signaling adaptor protein that contains two C-terminal leucine-rich domains which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. The protein plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the nucleotide oligomerization domain 2 protein have been associated with increased susceptibility to CROHN DISEASE.
Also Known As:
CARD15 Protein; Caspase Recruitment Domain Protein 15; Nucleotide Oligomerization Domain 2 Protein
Networked: 3
relevant articles (0 outcomes,
0 trials/studies)
Bio-Agent Context: Research Results
Experts
1. | Fraser, Alan:
1 article
(12/2008)
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2. | Hong, Jiwon:
1 article
(12/2008)
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3. | Krissansen, Geoffrey Wayne:
1 article
(12/2008)
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4. | Leung, Euphemia:
1 article
(12/2008)
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5. | Folwaczny, Christian:
1 article
(08/2004)
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6. | Folwaczny, Matthias:
1 article
(08/2004)
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7. | Glas, Jürgen:
1 article
(08/2004)
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8. | Mauermann, Daniel:
1 article
(08/2004)
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9. | Török, Helga-Paula:
1 article
(08/2004)
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10. | Cho, Judy H:
1 article
(01/2003)
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