Initiator Caspases

A subtype of caspases that contain long pro-domain regions that regulate the activation of the enzyme. The pro-domain regions contain protein-protein interaction motifs that can interact with specific signaling adaptor proteins such as DEATH DOMAIN RECEPTORS; DED SIGNALING ADAPTOR PROTEINS; and CARD SIGNALING ADAPTOR PROTEINS. Once activated, the initiator caspases can activate other caspases such as the EFFECTOR CASPASES.
Also Known As:
Caspases, Initiator
Networked: 29 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Salvesen, Guy S: 2 articles (06/2011 - 12/2006)
2. Li, Yang: 1 article (03/2014)
3. Lee, Seung-Ki: 1 article (03/2014)
4. Jin, Ying-Hua: 1 article (03/2014)
5. Guo, Xiao-Xi: 1 article (03/2014)
6. Sun, Chao: 1 article (03/2014)
7. Jin, Feng-Xie: 1 article (03/2014)
8. Lin, Ying-Jia: 1 article (03/2014)
9. Jiang, Dan: 1 article (03/2014)
10. Chow, S C: 1 article (11/2013)

Related Diseases

1. Liver Diseases (Liver Disease)
2. Neoplasms (Cancer)
3. Carcinoma (Carcinomatosis)
4. Infection
08/01/2005 - "Induction of apoptosis during Sendai virus (SeV) infection has previously been documented to be triggered by initiator caspases (for strain F) or by a contribution of the cellular protein TIAR (T-cell-activated intracellular antigen-related) (for strain Z). "
10/01/2010 - "Furthermore, TCDD was able to trigger BHV-1-induced apoptosis by up-regulating the activation of initiator caspases 8 and 9, as well as of effector caspase 3. Since TCDD activates caspase 3 after 4 h of infection, we have hypothesized an involvement of BHV-1 infected cell protein 0 (bICP0) in this process. "
12/01/2007 - "arMP-12-del21/384 replication triggered apoptosis, including the cleavage of caspase-3, the cleavage of its downstream substrate, poly(ADP-ribose) polymerase, and activation of the initiator caspases, caspase-8 and -9, earlier in infection than arMP-12. "
04/01/2005 - "An analysis of caspase activity, using fluorometric caspase assays and Western blots, indicated that each of the main initiator caspases, caspase-8, caspase-9, and caspase-12, were activated during infection with the rM51R-M virus. "
07/01/2008 - "gondii significantly reduced Fas/CD95-triggered apoptosis in HeLa cells by inhibiting the activities of initiator caspases 8 and 9 and effector caspase 3/7. Parasitic infection dose dependently diminished cleavage of caspase 8, the BH3-only protein Bid, and the downstream caspases 9 and 3. Importantly, interference with Fas/CD95-triggered caspase 8 and caspase 3/7 activities after parasitic infection was largely dependent on the presence of caspase 9. Within the mitochondrial amplification loop, T. "
5. Coronavirus Infections

Related Drugs and Biologics

1. Caspases
2. Death Domain Receptors
3. narciclasine
4. isocarbostyril
5. Caspase 8 (Caspase-8)
6. Caspase 3 (Caspase-3)
7. Caspase 9
8. Caspase 12
9. TNF-Related Apoptosis-Inducing Ligand Receptors
10. Caspase 2

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)