|1.||Salvesen, Guy S: 2 articles (06/2011 - 12/2006)|
|2.||Li, Yang: 1 article (03/2014)|
|3.||Lee, Seung-Ki: 1 article (03/2014)|
|4.||Jin, Ying-Hua: 1 article (03/2014)|
|5.||Guo, Xiao-Xi: 1 article (03/2014)|
|6.||Sun, Chao: 1 article (03/2014)|
|7.||Jin, Feng-Xie: 1 article (03/2014)|
|8.||Lin, Ying-Jia: 1 article (03/2014)|
|9.||Jiang, Dan: 1 article (03/2014)|
|10.||Chow, S C: 1 article (11/2013)|
|1.||Liver Diseases (Liver Disease)
01/01/2010 - "There is experimental evidence from transgenic mice that certain initiator caspases, such as caspase-8 and -2, might act as tumor suppressors. "
01/01/2010 - "Executioner caspases have only rarely been found mutated or silenced, and also initiator caspases are only affected in particular types of cancer. "
10/01/2012 - "Tumor size time series data from rodent tumor xenograft (COLO205) studies following administration of either of these two pro-apoptotic receptor agonists (PARAs) were combined to develop a intracellular-signaling tumor-regression model that includes two levels of signaling: upstream signals unique to each compound (representing initiator caspases), and a common downstream apoptosis signal (representing executioner caspases) shared by the two agents. "
11/01/2012 - "Pretreatment of cancer cells with pan caspase inhibitor, z-VAD inhibited activities of both initiator caspases (e.g., caspase-8 and -9) and executioner caspase-3. "
10/01/2005 - "The apoptogenic effect of this treatment involves enhanced expression of the death receptor DR5 and its cognate ligand, tumor necrosis factor-related apoptosis inducing ligand, both of which are known to induce apoptosis in a tumor cell-selective manner and lead to the activation of initiator caspases. "
09/01/2007 - "Our study has shown that the Amaryllidaceae isocarbostyril narciclasine induces marked apoptosis-mediated cytotoxic effects in human cancer cells but not in normal fibroblasts by triggering the activation of the initiator caspases of the death receptor pathway (caspase-8 and caspase-10) at least in human MCF-7 breast and PC-3 prostate carcinoma cells. "
08/01/2005 - "Induction of apoptosis during Sendai virus (SeV) infection has previously been documented to be triggered by initiator caspases (for strain F) or by a contribution of the cellular protein TIAR (T-cell-activated intracellular antigen-related) (for strain Z). "
10/01/2010 - "Furthermore, TCDD was able to trigger BHV-1-induced apoptosis by up-regulating the activation of initiator caspases 8 and 9, as well as of effector caspase 3. Since TCDD activates caspase 3 after 4 h of infection, we have hypothesized an involvement of BHV-1 infected cell protein 0 (bICP0) in this process. "
12/01/2007 - "arMP-12-del21/384 replication triggered apoptosis, including the cleavage of caspase-3, the cleavage of its downstream substrate, poly(ADP-ribose) polymerase, and activation of the initiator caspases, caspase-8 and -9, earlier in infection than arMP-12. "
04/01/2005 - "An analysis of caspase activity, using fluorometric caspase assays and Western blots, indicated that each of the main initiator caspases, caspase-8, caspase-9, and caspase-12, were activated during infection with the rM51R-M virus. "
07/01/2008 - "gondii significantly reduced Fas/CD95-triggered apoptosis in HeLa cells by inhibiting the activities of initiator caspases 8 and 9 and effector caspase 3/7. Parasitic infection dose dependently diminished cleavage of caspase 8, the BH3-only protein Bid, and the downstream caspases 9 and 3. Importantly, interference with Fas/CD95-triggered caspase 8 and caspase 3/7 activities after parasitic infection was largely dependent on the presence of caspase 9. Within the mitochondrial amplification loop, T. "
09/01/2013 - "Moreover, as is commonly observed for coronavirus infections of other animals, the activities of the effecter caspase, caspase-3, and the initiator caspases, caspase-8 and caspase-9, which are representative factors in the death receptor-mediated apoptotic pathway and the mitochondrial apoptotic pathway, respectively, were increased in PHEV-infected PK-15 cells. "
06/22/2008 - "Moreover, as is commonly observed in coronavirus infection in other animals, the activities of effecter caspases - caspase-3/7 - and initiator caspases - caspase-8 and caspase-9 - that are representative factors in the death receptor-mediated apoptotic pathway and mitochondrial apoptotic pathway, respectively, were increased in ECoV-infected MDBK cells. "
|2.||Death Domain Receptors
|5.||Caspase 8 (Caspase-8)
|6.||Caspase 3 (Caspase-3)
|9.||TNF-Related Apoptosis-Inducing Ligand Receptors
|1.||Heterologous Transplantation (Xenotransplantation)