|1.||Yoo, Nam Jin: 6 articles (01/2010 - 04/2002)|
|2.||Lee, Sug Hyung: 6 articles (01/2010 - 04/2002)|
|3.||Park, Won Sang: 4 articles (11/2002 - 04/2002)|
|4.||Kim, Hong Sug: 4 articles (11/2002 - 04/2002)|
|5.||Lee, Jung Young: 4 articles (11/2002 - 04/2002)|
|6.||Lenardo, Michael J: 3 articles (01/2007 - 09/2002)|
|7.||Kim, Su Young: 3 articles (11/2002 - 06/2002)|
|8.||Kim, Sang Ho: 3 articles (11/2002 - 06/2002)|
|9.||Lee, Jong Heun: 3 articles (06/2002 - 04/2002)|
|10.||Shin, Min Sun: 3 articles (06/2002 - 04/2002)|
01/01/2015 - "Treatment of MDA-MB-231 cells/tumors with SO resulted in more apoptotic cells (in tumors) and in vivo and in vitro, more CD95+ positive cells and a higher expression of apoptotic molecules caspase-10, Bad, or Bid (p < 0.05). "
12/07/2006 - "Altogether, these data indicate an active role for caspase-10 in cytotoxic drug-induced tumor cell death, downstream of the mitochondria."
12/07/2006 - "Caspase-10 involvement in cytotoxic drug-induced apoptosis of tumor cells."
10/01/2005 - "No tumors expressed significant amounts of caspase 10 or c-FLIP. "
06/01/2002 - "We expressed the tumor-derived caspase 10 mutants in 293 cells and found that apoptosis was suppressed. "
|2.||Autoimmune Lymphoproliferative Syndrome
01/01/2016 - "Autoimmune lymphoproliferative syndrome due to somatic FAS mutation (ALPS-sFAS) combined with a germline caspase-10 (CASP10) variation."
04/01/2006 - "Genetic alterations in caspase-10 may be causative or protective in autoimmune lymphoproliferative syndrome."
11/20/2001 - "A role for caspase-10, previously implicated in the autoimmune lymphoproliferative syndrome, in death receptor signaling has not been directly shown. "
07/09/1999 - "We report here two kindreds with autoimmune lymphoproliferative syndrome (ALPS) type II, characterized by abnormal lymphocyte and dendritic cell homeostasis and immune regulatory defects, that harbor independent missense mutations in Caspase 10. "
07/09/1999 - "Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II."
01/01/2009 - "The aim of this study was to explore whether CASP10 gene that encodes caspase-10 is somatically mutated in acute adulthood leukaemias and multiple myelomas (MMs). "
04/15/2013 - "Control of autophagic cell death by caspase-10 in multiple myeloma."
04/15/2013 - "However, in this issue of Cancer Cell, Lamy and colleagues report that multiple myeloma utilizes caspase-10 to restrain autophagy and undergoes autophagic cell death upon its removal or inhibition."
|4.||Systemic Lupus Erythematosus (Libman-Sacks Disease)
12/01/1999 - "ALPS is subdivided into: 1) Type Ia, ALPS with mutant Fas; 2) Type Ib, lymphadenopathy and mutation in the ligand for Fas in one patient with systemic lupus erythematosus; 3) Type II, ALPS with mutant caspase 10; and 4) Type III, ALPS as yet without any defined genetic cause."
01/01/2014 - "This study aimed to explore the role of apoptosis initiators, caspase-9, caspase-10, mitochondrial anti-viral signaling protein (MAVS), and interferon regulatory factor 7 (pIRF7), in patients with systemic lupus erythematosus (SLE). "
|5.||Colorectal Neoplasms (Colorectal Cancer)
12/01/2011 - "Our data indicate that caspase-10 expression, measured by quantitative real-time RT-PCR, is a possible prognostic factor in patients with stage II colorectal cancer."
12/01/2011 - "A multivariate analysis, performed by Cox's proportional hazards regression model, confirmed that a low caspase-10 expression was the only significant factor to predict poor prognosis in patients with stage II colorectal cancer. "
12/01/2011 - "Downregulation of caspase-10 predicting poor survival after resection of stage II colorectal cancer."
12/01/2011 - "Quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) was used to analyze caspase-10 expression in cancer tissue and corresponding normal mucosa from 120 patients with stage II colorectal cancer. "
12/01/2011 - "The aim of this study was to evaluate the prevalence and clinical significance of caspase-10 mRNA expression in stage II colorectal cancer. "
|1.||Caspase 8 (Caspase-8)
|3.||Messenger RNA (mRNA)
|4.||Interferon Regulatory Factor-7 (Interferon Regulatory Factor 7)
|5.||Small Interfering RNA (siRNA)
|7.||Caspase 3 (Caspase-3)
|8.||NF-kappa B (NF-kB)
|9.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|10.||Proteins (Proteins, Gene)
|1.||Drug Therapy (Chemotherapy)