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Caspase 10

A long pro-domain caspase that contains a death effector domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS. Caspase 10 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
Also Known As:
Caspase 10-a; Caspase 10-c; Caspase 10-d; Caspase 10a; Caspase 10c; Caspase 10d; Caspase-10; Mch4 Protease; Caspase 10 a; Caspase 10 c; Caspase 10 d; Protease, Mch4
Networked: 62 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Yoo, Nam Jin: 6 articles (01/2010 - 04/2002)
2. Lee, Sug Hyung: 6 articles (01/2010 - 04/2002)
3. Park, Won Sang: 4 articles (11/2002 - 04/2002)
4. Kim, Hong Sug: 4 articles (11/2002 - 04/2002)
5. Lee, Jung Young: 4 articles (11/2002 - 04/2002)
6. Lenardo, Michael J: 3 articles (01/2007 - 09/2002)
7. Kim, Su Young: 3 articles (11/2002 - 06/2002)
8. Kim, Sang Ho: 3 articles (11/2002 - 06/2002)
9. Lee, Jong Heun: 3 articles (06/2002 - 04/2002)
10. Shin, Min Sun: 3 articles (06/2002 - 04/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Autoimmune Lymphoproliferative Syndrome
3. Multiple Myeloma
4. Systemic Lupus Erythematosus (Libman-Sacks Disease)
5. Colorectal Neoplasms (Colorectal Cancer)

Related Drugs and Biologics

1. Caspase 8 (Caspase-8)
2. Caspase 9
3. Messenger RNA (mRNA)
4. Interferon Regulatory Factor-7 (Interferon Regulatory Factor 7)
5. Small Interfering RNA (siRNA)
6. Platinum
7. Caspase 3 (Caspase-3)
8. NF-kappa B (NF-kB)
9. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
10. Proteins (Proteins, Gene)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)