|1.||Delivoria-Papadopoulos, Maria: 13 articles (08/2012 - 07/2004)|
|2.||Mishra, Om P: 12 articles (08/2010 - 07/2004)|
|3.||Ashraf, Qazi M: 8 articles (12/2008 - 03/2007)|
|4.||Kim, Sung-Hoon: 7 articles (07/2015 - 10/2004)|
|5.||Schulze-Osthoff, Klaus: 7 articles (04/2012 - 10/2006)|
|6.||Dent, Paul: 6 articles (10/2013 - 05/2002)|
|7.||Chung, Jing-Gung: 6 articles (10/2013 - 01/2009)|
|8.||Grant, Steven: 5 articles (10/2013 - 05/2002)|
|9.||Yang, Jai-Sing: 5 articles (09/2012 - 01/2009)|
|10.||Wang, Shaomeng: 5 articles (05/2012 - 05/2004)|
01/01/2012 - "We assessed published studies of the association between caspase 9 polymorphisms and cancer risk from nine studies with 5,528 subjects for rs4645978, six studies with 2,403 subjects for rs105276 and two studies for rs4645981. "
05/01/2004 - "The aim of this study was to identify extrinsic and intrinsic tumor-induced apoptotic pathways in DC by targeting different anti-apoptotic molecules, including FLIP, XIAP/hILP, dominant-negative procaspase-9 and HSP70. "
01/01/2015 - "Therefore, a deep understanding on the roles as well as regulators of caspase-9 is required to find more effective ways to conquer apoptosis-related diseases especially cancer."
01/01/2015 - "Caspase-9 as a therapeutic target for treating cancer."
12/28/2014 - "Moreover, SKLB316 could induce cancer cell apoptosis, which was associated with activation of caspase 9, downregulation of Bcl-2 and upregulation of Bax. "
04/05/2002 - "In the present study, performed in the isolated rat heart exposed either to ischemia alone or ischemia followed by reperfusion, cleavage of caspase-9 was observed primarily in endothelial cells. "
03/01/2012 - "Thirty minutes and 24 h preconditioning with rhEPO (1,000 IU/kg) increased Bcl-xL/Bax ratio and reduced caspase-9 activity, and the same effect was observed when higher dose was given 24 h before ischemia. "
05/21/2010 - "Moreover, GRP78, caspase-9 and TUNEL cells emerge one after another during ischemia. "
09/01/2009 - "Herba Erigerontis Breviscapi Injection intervention could decrease the rate of apoptotic cells and the contents of caspase-9 and AIF in cytoplasm and serum as compared with those in the ischemia-reperfusion group, and the effects appeared after 1 h reperfusion. "
03/14/2003 - "Hu-Bcl-2 overexpression delays the activation of the cell death molecular machinery but does not control the ischemia-induced change in procaspase 9 L and S. "
01/01/2013 - "Our study investigated the apoptotic mechanism of rat cortical neurons following hypoxia/reperfusion induced endoplasmic reticulum stress (ERS) in vitro and to explore the effect of caspase-9 inhibition on ERS induced apoptosis. "
12/05/2008 - "The results of this study demonstrate that caspase-9, a key protein in hypoxia induced apoptosis, is phosphorylated at the Ser(196) site during hypoxia. "
01/01/2013 - "These results demonstrated that ERS is involved in the neuronal apoptosis following in vitro hypoxia/reperfusion, and caspase-9 inhibition can depress the ERS induced apoptosis of neurons. "
01/01/2013 - "Following pre-treatment with caspase-9 inhibitor, the number of apoptotic cells was significantly reduced following hypoxia for 6 and reperfusion for 24 h or 48 h (P < 0.05). "
01/01/2013 - "Moreover, Ntn-1 decreased the increase of hypoxia-induced Bax, cleaved caspase-9, and -3, but blocked the decrease of hypoxia-reduced Bcl-2. "
|4.||Breast Neoplasms (Breast Cancer)
01/01/2015 - "The fused TAT-DV1-BH3 polypeptide colocalized with mitochondria and exhibited a proapoptotic effect through the regulation of caspase-9 and -3. Furthermore, the fused TAT-DV1-BH3 polypeptide suppressed the migration and invasion of the highly metastatic breast cancer cell line MDA-MB-231 in a concentration-dependent manner. "
01/01/2015 - "Enterocarpam-III induces human liver and breast cancer cell apoptosis via mitochondrial and caspase-9 activation."
10/01/2012 - "Caspase 9 promoter polymorphisms confer increased susceptibility to breast cancer."
01/23/2009 - "The protein expression levels of the active forms of caspase-9 and Bax in breast cancer cells were significantly increased by treatment with PR metabolites. "
05/01/2010 - "Recently, several studies have reported that OPN enhances chemoresistance in small-cell lung cancer and breast cancer by blocking caspase-9 and caspase-3-dependent cell apoptosis. "
04/01/2007 - "The aim of this study was to explore whether phosphorylated caspase-9 (p-caspase-9) expression could be a characteristic of gastric carcinomas. "
08/15/2010 - "Caspase-9 may be an independent prognosticator in colon carcinoma."
04/01/2007 - "Taken together, these results indicate that caspase-9 is frequently phosphorylated in gastric carcinomas, and that the phosphorylation of caspase-9 might be an inhibitory mechanism of caspase-9-mediated apoptosis in gastric carcinomas. "
04/01/2007 - "Expression of phosphorylated caspase-9 in gastric carcinomas."
04/01/2006 - "Mutational analysis of proapoptotic caspase-9 gene in common human carcinomas."
|1.||Caspase 3 (Caspase-3)
|2.||Cytochromes c (Cytochrome c)
|3.||Caspase 8 (Caspase-8)
|4.||Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
|5.||Proteins (Proteins, Gene)
|6.||Reactive Oxygen Species (Oxygen Radicals)
|7.||benzyloxycarbonyl- leucyl- glutamyl- histidyl- aspartic acid fluoromethyl ketone
|8.||Messenger RNA (mRNA)
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Drug Therapy (Chemotherapy)
|3.||Diet Therapy (Therapy, Diet)