TNF Receptor-Associated Factor 4

A widely expressed member of the TNF receptor-associated family that may play a role in neuronal development and EMBRYOGENESIS. Although TNF receptor-associated factor 4 does not strongly associate with TUMOR NECROSIS FACTOR RECEPTORS it may be a signaling partner with the GLUCOCORTICOID-INDUCED TNFR-RELATED PROTEIN that plays a role in the activation of JNK MITOGEN-ACTIVATED PROTEIN KINASES and NF-KAPPA B.

Also Known As:

Networked: 114 relevant articles (7 outcomes, 28 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wang, Jian: 7 articles (01/2022 - 06/2013)
2.	Mi, Xiaoyi: 6 articles (01/2022 - 06/2013)
3.	Alpy, Fabien: 6 articles (01/2014 - 01/2008)
4.	Rousseau, Adrien: 6 articles (01/2014 - 06/2011)
5.	Yang, Fan: 5 articles (11/2015 - 10/2014)
6.	Tomasetto, Catherine: 5 articles (01/2014 - 01/2008)
7.	Mi, Xiao-Yi: 4 articles (11/2015 - 10/2007)
8.	Rio, Marie-Christine: 4 articles (12/2013 - 01/2008)
9.	Zhang, Long: 3 articles (10/2022 - 09/2013)
10.	Diao, Kexin: 3 articles (01/2022 - 10/2014)

Related Diseases

1.	Neoplasms (Cancer) 12/19/2022 - "Depletion of TRAF4 markedly improved the sensitivity of OSCC cells to irradiation (IR) treatment, showing that tumor cell proliferation, colony formation and xenograft tumor growth were reduced. " 03/01/2021 - "Our findings support the notion that TRAF4/6 mediates pro-tumorigenic effects of CD44, and suggests that inhibitors of CD44 signaling via TRAF4/6 and RAC1 may be beneficial in the treatment of tumor patients." 10/01/2023 - "The present study found that TRAF4 was significantly increased in CRC clinical tumor samples. " 12/19/2022 - "The present study found that TRAF4 was significantly upregulated in primary and relapsed OSCC tumor tissues. " 12/01/2014 - "Although numerous studies have suggested that there is elevated TRAF4 expression in human cancer, it is still unknown in which oncogenic pathway TRAF4 is mainly implicated. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2022 - "In summary, our study suggests a new direction for investigating the role of TRAF4 in driving breast cancer progression." 05/01/2015 - "The aim of the present study was to analyze the correlation, expression and nuclear and cytoplasmic localizations of TRAF4 and Girdin in breast cancer tissues. " 02/01/2014 - "The present study investigated the expression and anti-apoptotic function of TRAF4 in human breast cancer MCF-7 cells. " 10/01/2007 - "This study was to investigate the expression of TRAF4 in normal breast, breast carcinoma tissue, and cell lines with different invasive abilities. " 01/01/2022 - "Relying on its Zinc fingers domain, TRAF4 interacted with Eg5 in the cytoplasm of breast cancer cells. "
3.	Ovarian Neoplasms (Ovarian Cancer) 01/10/2023 - "Our study demonstrated that SRC-3/TRAF4 promotes ovarian cancer cell growth, migration, invasion, and stemness by activating the PI3K/AKT pathway." 01/10/2023 - "This study aimed to explore the role of the SRC-3/TRAF4/PI3K/AKT pathway in ovarian cancer development. " 02/01/2023 - "Knocking down USP7 suppressed viability, migration, and invasion of ovarian cancer cells; TRAF4 knockdown and RSK4 overexpression had similar effects in ovarian cancer cells. " 02/01/2023 - "The results showed USP7 and TRAF4 upregulation, and RSK4 downregulation in ovarian cancer cell lines. " 02/01/2023 - "We conducted quantitative real-time PCR to detect the expression of USP7, TRAF4, and RSK4 in ovarian cancer cell lines. "
4.	Neuroblastoma 07/01/2023 - "The high expression of TRAF4 was associated with a poor prognosis in human neuroblastoma. " 07/01/2023 - "We discovered that all TRAFs were efficiently expressed in neuroblastoma, but TRAF4, in particular, was found to be strongly expressed. " 07/01/2023 - "The inhibition of TRAF4, rather than other TRAFs, improved retinoic acid sensitivity in two human neuroblastoma cell lines, SH-SY5Y and SK-N-AS cells. " 07/01/2023 - "TRAF4 Silencing Induces Cell Apoptosis and Improves Retinoic Acid Sensitivity in Human Neuroblastoma." 07/01/2023 - "In conclusion, the highly expressed TRAF4 might be implicated in developing resistance to retinoic acid treatment in neuroblastoma, and the combination therapy with retinoic acid and TRAF4 inhibition may offer significant therapeutic advantages in the treatment of relapsed neuroblastoma."
5.	Carcinoma (Carcinomatosis) 09/01/2018 - "Overexpression of KIF11 or TRAF4 eliminated the suppression of carcinoma cell migration by DR6 knockdown. " 09/01/2018 - "We also found that TRAF4 and KIF11 were upregulated in ovarian carcinomas and that their level of expression was positively correlated with that of DR6. " 09/01/2015 - "MLPA assay revealed gene copy gains of MYC, CCND1, ZNF703, CDH1, and TRAF4 in 50% or greater of the apocrine carcinomas, whereas gene copy losses frequently affected BRCA2 (75%), ADAM9 (54%), and BRCA1 (46%). " 01/01/2008 - "In vivo, TRAF4 is consistently found at TJs in normal human mammary epithelia as well as in well-differentiated in situ carcinomas. " 01/04/2007 - "To investigate changes in TRAF4 gene copy number, 125 cases from six different types of carcinomas were also analysed by fluorescence in situ hybridization. "

Related Drugs and Biologics

1.	Tretinoin (Retinoic Acid)
2.	TNF Receptor-Associated Factor 2 (TRAF2)
3.	TNF Receptor-Associated Factor 6 (TRAF6)
4.	TNF Receptor-Associated Factor 5
5.	Trastuzumab (Herceptin)
6.	wogonoside
7.	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
8.	Proteins (Proteins, Gene)
9.	Biomarkers (Surrogate Marker)
10.	Catenins

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy
3.	Prostatectomy (Retropubic Prostatectomy)
4.	Drug Therapy (Chemotherapy)