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Chromogranin B

A type of chromogranin which was initially characterized in a rat PHEOCHROMOCYTOMA CELL LINE. It is found in many species including human, rat, mouse, and others. It is an acidic protein with 626 to 657 amino acid residues. In some species, it inhibits secretion of PARATHYROID HORMONE or INSULIN and exerts bacteriolytic effects in others.
Also Known As:
Secretogranin I
Networked: 87 relevant articles (0 outcomes, 9 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Stridsberg, Mats: 8 articles (08/2013 - 03/2003)
2. Mahata, Sushil K: 5 articles (04/2010 - 01/2004)
3. Marksteiner, Josef: 5 articles (03/2008 - 02/2002)
4. Blennow, Kaj: 3 articles (07/2013 - 12/2007)
5. Zetterberg, Henrik: 3 articles (07/2013 - 12/2007)
6. Humpel, Christian: 3 articles (03/2008 - 02/2002)
7. Adlassnig, Christine: 3 articles (01/2004 - 11/2002)
8. Kaufmann, Walter A: 3 articles (01/2004 - 02/2002)
9. Mattsson, Niklas: 2 articles (01/2012 - 12/2007)
10. Camu, William: 2 articles (05/2011 - 12/2009)

Related Diseases

1. Carcinoid Tumor (Carcinoid)
01/01/1995 - "In contrast, strong chromogranin B and secretogranin II immunoreactivity was found in rectal carcinoids, in which chromogranin A was rarely expressed. "
06/01/1997 - "We investigated polysiaN-CAM immunoreactivity in a range of neuroendocrine lung tumours: 15 typical carcinoids, 21 atypical carcinoids, 2 large cell neuroendocrine carcinomas and 12 small cell lung carcinomas were selected on a morphological basis and by their immunoreactivity for chromogranin A and B and secretogranin II. A progressive loss of chromogranin expression, particularly of chromogranin B, was paralleled by the up-regulation of polysiaN-CAM in histologically more aggressive tumours (P = 0.001). "
03/01/1994 - "In 17 prostatic carcinomas with pronounced neuroendocrine differentiation and in a case of prostatic carcinoid, chromogranin B was the major component whereas chromogranin A and secretogranin II were virtually absent in poorly differentiated (grade III) tumours. "
11/01/1998 - "The aim of the present study was to investigate immunohistochemically the distribution of secretoneurin, a novel 33 amino acid peptide, in comparison to chromogranin A, chromogranin B, and secretogranin II in carcinoids of the appendix. "
01/01/1995 - "In 44 patients with carcinoid tumours, 17 patients with sporadic endocrine pancreatic tumours and 11 patients with endocrine pancreatic tumours and the multiple endocrine neoplasia 1 syndrome, plasma measurements revealed elevated chromogranin A levels in 99%, elevated chromogranin B in 88%, elevated chromogranin C in 6% and elevated pancreastatin in 46% of the patients. "
2. Neoplasms (Cancer)
3. Pheochromocytoma
4. Neuroendocrine Tumors (Neuroendocrine Tumor)
5. Schizophrenia (Dementia Praecox)

Related Drugs and Biologics

1. Chromogranin A
2. Secretogranin II
3. secretoneurin
4. Chromogranins
5. Phosphopyruvate Hydratase (Enolase)
6. Synaptophysin
7. Antigens
8. superoxide dismutase 1
9. Chromogranin B
10. Antibodies

Related Therapies and Procedures

1. Ligation