Chromogranin B

A type of chromogranin which was initially characterized in a rat PHEOCHROMOCYTOMA CELL LINE. It is found in many species including human, rat, mouse, and others. It is an acidic protein with 626 to 657 amino acid residues. In some species, it inhibits secretion of PARATHYROID HORMONE or INSULIN and exerts bacteriolytic effects in others.

Also Known As:

Networked: 107 relevant articles (0 outcomes, 11 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Stridsberg, Mats: 9 articles (12/2017 - 03/2003)
2.	Mahata, Sushil K: 5 articles (04/2010 - 01/2004)
3.	Marksteiner, Josef: 5 articles (03/2008 - 02/2002)
4.	Heidrich, Felix M: 3 articles (01/2020 - 11/2011)
5.	Strasser, Ruth H: 3 articles (01/2020 - 11/2011)
6.	Julien, Jean-Pierre: 3 articles (11/2016 - 12/2009)
7.	Blennow, Kaj: 3 articles (07/2013 - 12/2007)
8.	Zetterberg, Henrik: 3 articles (07/2013 - 12/2007)
9.	Humpel, Christian: 3 articles (03/2008 - 02/2002)
10.	Adlassnig, Christine: 3 articles (01/2004 - 11/2002)

Related Diseases

1.	Carcinoid Tumor (Carcinoid) 01/01/1995 - "In contrast, strong chromogranin B and secretogranin II immunoreactivity was found in rectal carcinoids, in which chromogranin A was rarely expressed. " 03/01/1994 - "In 17 prostatic carcinomas with pronounced neuroendocrine differentiation and in a case of prostatic carcinoid, chromogranin B was the major component whereas chromogranin A and secretogranin II were virtually absent in poorly differentiated (grade III) tumours. " 06/01/1997 - "We investigated polysiaN-CAM immunoreactivity in a range of neuroendocrine lung tumours: 15 typical carcinoids, 21 atypical carcinoids, 2 large cell neuroendocrine carcinomas and 12 small cell lung carcinomas were selected on a morphological basis and by their immunoreactivity for chromogranin A and B and secretogranin II. A progressive loss of chromogranin expression, particularly of chromogranin B, was paralleled by the up-regulation of polysiaN-CAM in histologically more aggressive tumours (P = 0.001). " 01/01/1995 - "In 44 patients with carcinoid tumours, 17 patients with sporadic endocrine pancreatic tumours and 11 patients with endocrine pancreatic tumours and the multiple endocrine neoplasia 1 syndrome, plasma measurements revealed elevated chromogranin A levels in 99%, elevated chromogranin B in 88%, elevated chromogranin C in 6% and elevated pancreastatin in 46% of the patients. " 01/01/2004 - "Paraffin-embedded tissues from 30 carcinoid tumors of the appendix and 16 other carcinoid tumors (5 bronchus-, 5 stomach-, 2 small bowel-, 4 large bowel carcinoid tumors) were incubated with antibodies specific for catestatin, chromogranin A and chromogranin B. "
2.	Neuroendocrine Tumors (Neuroendocrine Tumor) 08/15/2022 - "Chromogranin B in blood serum of patients with neuroendocrine tumors." 06/01/2017 - "The present study aimed to evaluate the utility of chromogranin B as a pancreatic neuroendocrine tumor biomarker. " 02/01/2000 - "Although chromogranin A (CgA) is widely distributed in neuroendocrine tumors, the distribution of chromogranin B (CgB) has not been elucidated. " 06/01/2017 - "In addition, chromogranin B may be an excellent biomarker when differentiation of pancreatic neuroendocrine tumor from other pancreatic diseases is required." 06/01/2017 - "In addition, the logistic regression analysis showed that chromogranin B was superior to chromogranin A in differentiation of pancreatic neuroendocrine tumor from other pancreatic diseases. "
3.	Neoplasms (Cancer) 01/01/1995 - "Identification of a new chromogranin B fragment (314-365) in endocrine tumors." 06/01/2013 - "Lower cytoplasmic chromogranin B (CHGB) expression (p = 0.03) was associated with malignant tumors and metastasis. " 12/01/1994 - "Two of 15 squamous-cell carcinomas showed chromogranin B reactivity in more than 20% of tumor cells. " 03/01/1994 - "Neuroendocrine differentiation in prostatic cancer is most likely to be associated with a poor clinical outcome; thus, chromogranin B appears to be a useful marker in the histopathological diagnosis of these neoplasms." 11/30/2010 - "Circulating concentrations of chromogranin B-like immunoreactivity (CgB-LI) are not elevated in non-neoplastic diseases and measurements of CCB, the COOH-terminal fragment of CgB, may be useful as a biochemical marker for neuroendocrine differentiation in lung tumors. "
4.	Pheochromocytoma 09/01/2001 - "Evidence that the chromogranin B fragment 368-417 extracted from a pheochromocytoma is phosphorylated." 12/31/1992 - "Sorting of chromogranin B into immature secretory granules in pheochromocytoma (PC12) cells." 04/25/1991 - "Chromogranin B: isolation from pheochromocytoma, N-terminal sequence, tissue distribution and secretory vesicle processing." 01/01/2019 - "Molecular Profiling of Pheochromocytoma and Abdominal Paraganglioma Stratified by the PASS Algorithm Reveals Chromogranin B as Associated With Histologic Prediction of Malignant Behavior." 11/01/1988 - "In benign pheochromocytomas, all three antigens were found consistently; whereas in two of three malignant pheochromocytomas, chromogranin B was absent. "
5.	Schizophrenia (Dementia Praecox) 01/01/2007 - "The Chromogranin B (CHGB) gene has been proposed as a candidate gene for predisposition to schizophrenia due to its location on the genome, the evidence of genetic studies, and its functional role in schizophrenia. " 01/01/2007 - "Further evidence that the chromogranin B gene confers predisposition to schizophrenia: a family-based association study in Chinese." 07/01/2004 - "Association between chromogranin b gene polymorphisms and schizophrenia in the Japanese population." 11/01/2002 - "Reduction of chromogranin B-like immunoreactivity in distinct subregions of the hippocampus from individuals with schizophrenia." 05/03/2002 - "Using functional and positional evidences, chromogranin B was selected as a candidate gene for schizophrenia. "

Related Drugs and Biologics

1.	Chromogranin A
2.	Secretogranin II
3.	secretoneurin
4.	Chromogranins
5.	Biomarkers (Surrogate Marker)
6.	Phosphopyruvate Hydratase (Enolase)
7.	Peptides (Polypeptides)
8.	Catecholamines
9.	Synaptophysin
10.	Antigens

Related Therapies and Procedures

1.	Ligation