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Ectodysplasins

Transmembrane proteins belonging to the tumor necrosis factor superfamily that play an essential role in the normal development of several ectodermally derived organs. Several isoforms of the ectodysplasins exist due to multiple ALTERNATIVE SPLICING of the MRNA for the protein. The isoforms ectodysplasin A1 and ectodysplasin A2 are considered biologically active and each bind distinct ECTODYSPLASIN RECEPTORS. Genetic mutations that result in loss of function of ectodysplasin result in ECTODERMAL DYSPLASIA 1, ANHIDROTIC.
Also Known As:
Ectodysplasin; Ectodysplasin A, Isoform 1; Ectodysplasin A, Isoform 2; Ectodysplasin A1; Ectodysplasin A2; Ectodysplasin-A; Ectodysplasin A
Networked: 37 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Schneider, Pascal: 5 articles (02/2014 - 10/2004)
2. Gaide, Olivier: 4 articles (02/2014 - 10/2004)
3. Mikkola, Marja L: 3 articles (06/2014 - 10/2004)
4. Tardivel, Aubry: 2 articles (02/2014 - 11/2007)
5. Ye, Xiaoqian: 2 articles (01/2013 - 01/2013)
6. Yin, Wei: 2 articles (01/2013 - 01/2013)
7. Bian, Zhuan: 2 articles (01/2013 - 01/2013)
8. Casal, Margret L: 2 articles (09/2009 - 11/2007)
9. Mauldin, Elizabeth A: 2 articles (09/2009 - 11/2007)
10. Laurikkala, Johanna: 2 articles (01/2007 - 10/2004)

Related Diseases

1. Anodontia
2. Ectodermal Dysplasia (Aplasia Cutis Congenita)
3. Necrosis
4. Hypohidrosis
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Hypohidrotic Ectodermal Dysplasia
2. Edar Receptor
3. Ectodysplasin Receptors
4. NF-kappa B (NF-kB)
5. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6. Interleukin-17 (Interleukin 27)
7. Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
8. Biological Markers (Surrogate Marker)
9. Transcription Factors (Transcription Factor)
10. Proteins (Proteins, Gene)

Related Therapies and Procedures

1. Cell Transplantation