Tumor Necrosis Factor Ligand Superfamily Member 13

A member of tumor necrosis factor superfamily found on MACROPHAGES; DENDRITIC CELLS and T-LYMPHOCYTES. It occurs as transmembrane protein that can be cleaved to release a secreted form that specifically binds to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; and B CELL MATURATION ANTIGEN.

Also Known As:

Networked: 12 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Afonyushkin, Taras: 1 article (01/2021)
2.	Binder, Christoph J: 1 article (01/2021)
3.	Borén, Jan: 1 article (01/2021)
4.	Clement, Marc: 1 article (01/2021)
5.	Danchin, Nicolas: 1 article (01/2021)
6.	Donzé, Olivier: 1 article (01/2021)
7.	Enders, Lennart: 1 article (01/2021)
8.	Eslami, Mahya: 1 article (01/2021)
9.	Fogelstrand, Per: 1 article (01/2021)
10.	Frommlet, Florian: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2016 - "Results: APRIL protein expression positive rate of CRC tissue and cancer adjacent normal mucosal tissue were 83.33% (100/120) and 12.5% (15/120), with a statistical significance (P<0.001). " 02/01/2014 - "To examine high expression of tumor necrosis factor ligand superfamily member 13 (TNFSF13), which is correlated with several malignancies. " 03/01/2013 - "Herein, we report a humanized antibody (Ab) that neutralizes APRIL protein and inhibits cancer cell proliferation both in vitro and in vivo. " 08/01/2009 - "APRIL protein expression was also observed in tumor tissues by Western blot and immunohistochemistry. " 08/01/2009 - "The expression analysis revealed APRIL expression was elevated in non-small cell lung cancer (NSCLC) and the expression of APRIL protein was located in the membrane and cytoplasm of tumor cells by immunohistochemiscal staining. "
2.	Atherosclerosis 01/01/2021 - "Furthermore, the serum levels of a form of human APRIL protein that binds to HSPGs, which we termed non-canonical APRIL (nc-APRIL), are associated independently of traditional risk factors with long-term cardiovascular mortality in patients with atherosclerosis. "
3.	Virus Diseases (Viral Diseases) 01/01/2013 - "We measured BAFF and APRIL protein expression in bronchoalveolar lavage (BAL) fluid from infants with severe RSV disease, and healthy control children, and in nasopharyngeal aspirates from preschool children with other single respiratory viral infections. "
4.	Schizophrenia (Dementia Praecox) 01/01/2012 - "By data-mining approaches, we identified significant expression changes in death receptor signaling pathways in the dorsolateral prefrontal cortex (DLPFC) of patients with schizophrenia, particularly implicating the Tumor Necrosis Factor Superfamily member 6 (FAS) receptor and the Tumor Necrosis Factor [ligand] Superfamily member 13 (TNFSF13) in schizophrenia. "
5.	Necrosis 01/01/2015 - "The "A proliferation inducing ligand" protein (APRIL) is a cytokine over-expressed in many transformed and tumoral cells acting onto two distinct receptors of the Tumoral Necrosis Factor B cell maturation antigen (BCMA) and the transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI). "

Related Drugs and Biologics

1.	Cytokines
2.	Ligands
3.	Death Domain Receptors
4.	Cyclophilins (Cyclophilin)
5.	CXC Chemokines
6.	fas Receptor (CD95 Antigen)
7.	Chemokines
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
9.	Complement Factor B (Factor B)
10.	Calcium