OX40 Ligand

A membrane-bound tumor necrosis family member that is expressed on activated antigen-presenting cells such as B-LYMPHOCYTES and MACROPHAGES. It signals T-LYMPHOCYTES by binding the OX40 RECEPTOR.

Also Known As:

CD134 Ligand; CD134L Protein; OX40L Protein; TNF Superfamily, Member 4; Tumor Necrosis Factor (Ligand) Superfamily, Member 4; gp34 Tumor Necrosis Factor; Tumor Necrosis Factor Ligand Superfamily Member 4

Networked: 112 relevant articles (2 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ishii, Naoto: 6 articles (01/2016 - 04/2003)
2.	Tanaka, Yuetsu: 5 articles (02/2016 - 10/2010)
3.	Sugamura, Kazuo: 4 articles (12/2010 - 04/2003)
4.	He, Yayi: 3 articles (01/2021 - 01/2019)
5.	Wang, Hao: 3 articles (01/2021 - 01/2019)
6.	Zhao, Sha: 3 articles (01/2021 - 01/2019)
7.	Lei, Wei: 3 articles (01/2018 - 05/2012)
8.	Kikuchi, Toshiaki: 3 articles (01/2016 - 05/2004)
9.	Liu, Yong-Jun: 3 articles (03/2011 - 08/2007)
10.	Yagita, Hideo: 3 articles (02/2006 - 04/2003)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2023 - "In Situ Reprogramming of Tumors for Activating the OX40/OX40 Ligand Checkpoint Pathway and Boosting Antitumor Immunity." 01/01/2023 - "Immune co-stimulator OX40 ligand (OX40L) boosts anti-tumor immunity response by delivering a potent costimulatory signal to CD4+ and CD8+ T cells. " 02/01/2022 - "Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is an inflammatory factor that has been discussed in different inflammatory diseases and cancers. " 11/15/2021 - "Detectable OX40L protein levels were observed in 15% of primary uterine/ovarian serous malignancies and associated with longer survival. " 01/01/2021 - "OX40 and OX40 ligand (OX40L), as essential immune checkpoint (IC) modulators, are highly correlated with cancer immunity regulation as well as tumor microenvironment (TME). "
2.	Tuberculosis (Tuberculoses) 03/15/2012 - "OX40 ligand fusion protein delivered simultaneously with the BCG vaccine provides superior protection against murine Mycobacterium tuberculosis infection."
3.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 07/01/2013 - "To more precisely estimate the association between the tumor necrosis factor ligand superfamily member 4 (TNFSF4) gene polymorphisms and systemic lupus erythematosus (SLE) risk, we surveyed studies on the association of the TNFSF4 rs2205960, rs1234315, rs844644, and rs844648 polymorphisms with SLE. " 01/01/2021 - "To more precisely estimate the association between the tumor necrosis factor ligand superfamily member 4 (TNFSF4) gene polymorphisms and systemic lupus erythematosus (SLE) susceptibility, we performed a meta-analysis on the association of the following single nucleotide polymorphisms (SNPs) of TNFSF4 with SLE: rs1234315, rs844648, rs2205960, rs704840, rs844644, rs10489265. " 01/01/2017 - "Ox40 ligand (Ox40L) locus genetic variants are associated with the risk for systemic lupus erythematosus (SLE); however, it is unclear how Ox40L contributes to SLE pathogenesis. " 05/01/2012 - "The known tumor necrosis factor (ligand) superfamily, member 4 gene (TNFSF4) systemic lupus erythematosus (SLE) risk locus has been found to be associated with systemic sclerosis (SSc) in 2 studies, but with discrepancies between them for genotype-phenotype correlation. " 12/01/2017 - "The tumor necrosis factor ligand superfamily member 4 (TNFSF4) gene encodes a vital co-stimulatory molecule of the immune system and has been identified as a susceptibility locus for systemic lupus erythematosus, systemic sclerosis, and primary Sjögren's syndrome. "
4.	Asthma (Bronchial Asthma) 06/01/2006 - "This study was conducted to evaluate the role of another costimulatory pathway OX40/OX40 ligand (L) in the pathogenesis of allergic asthma in BALB/c mice. " 01/01/2018 - "Asthma was induced by OVA exposure and subsequent co‑treatment with OX40L protein, neutralizing anti‑OX40L blocking antibody, OX40+ T cells or PBS. " 05/15/2015 - "Here, we found for the first time that in a mouse model of allergic asthma basophils highly expressed OX40 ligand (OX40L) after activation. " 08/01/2014 - "OX40 ligand: a potential costimulatory molecule in atopic asthma." 07/01/2014 - "Immunohistochemistry assay showed that OX40 and OX40L protein levels were higher in asthma group than those in control group (all P<0.05). "
5.	Inflammation (Inflammations) 01/15/2013 - "This study aims to investigate the role of OX40 ligand (OX40L) in ocular inflammation via abrogation of retinal pigment epithelium (RPE)-mediated immunosuppression using an in vitro expression approach. " 05/15/2015 - "Basophil-associated OX40 ligand participates in the initiation of Th2 responses during airway inflammation." 10/15/2010 - "OX40 ligand regulates inflammation and mortality in the innate immune response to sepsis." 12/01/1999 - "The expression of MAdCAM-1 and OX40 ligand on gut endothelial and OX40+ cells is increased in sites of mucosal inflammation in patients with inflammatory bowel disease. " 02/01/2015 - "In conclusion, the thymic stromal lymphopoietin/OX40 ligand axis is up-regulated in nasal polyposis and is related to the intensity of eosinophilic inflammation. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Indicators and Reagents (Reagents)
3.	BCG Vaccine
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Ligands
6.	4-1BB Ligand (4 1BB Ligand)
7.	CD40 Ligand (CD40L)
8.	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
9.	Antigens
10.	Glucocorticoids

Related Therapies and Procedures

1.	Immunotherapy