B-Cell Activation Factor Receptor

A member of the tumor necrosis factor receptor superfamily that specifically binds B-CELL ACTIVATING FACTOR. It is found on B-LYMPHOCYTES and plays a role in maturation and survival of B-cells. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

Also Known As:

B Cell-Activating Factor Receptor; BAFF Receptor; BR3 B-Cell Activation Factor Receptor; CD268 Antigen; Receptor, B Cell-Activating Factor; Antigen, CD268; B Cell Activating Factor Receptor; B Cell Activation Factor Receptor; BR3 B Cell Activation Factor Receptor; Receptor, B Cell Activating Factor; Receptor, BAFF; Antigens, CD268; CD268 Antigens; Tumor Necrosis Factor Receptor Superfamily, Member 13C

Networked: 86 relevant articles (3 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Cytokine Receptors: 1620
        Tumor Necrosis Factor Receptors: 3685
        B-Cell Activation Factor Receptor: 86
        human TNFRSF13C protein
        mouse Tnfrsf13c protein

Experts

1.	Bobik, Alex: 3 articles (02/2017 - 01/2012)
2.	Kyaw, Tin: 3 articles (02/2017 - 01/2012)
3.	Tipping, Peter: 3 articles (02/2017 - 01/2012)
4.	Toh, Ban-Hock: 3 articles (02/2017 - 01/2012)
5.	Eibel, Hermann: 3 articles (05/2015 - 08/2009)
6.	Grimbacher, Bodo: 3 articles (04/2014 - 12/2005)
7.	Salzer, Ulrich: 3 articles (04/2014 - 12/2005)
8.	Parameswaran, Reshmi: 2 articles (01/2021 - 06/2014)
9.	Cheng, Wesley A: 2 articles (01/2019 - 01/2018)
10.	Dong, Zhenyuan: 2 articles (01/2019 - 01/2018)

Related Diseases

1.	Atherosclerosis 02/01/2017 - "Depletion of B2 cells by administration of mAb to CD20 or to BAFF receptor or in BAFF receptor-deficient mice ameliorates atherosclerosis. " 11/13/2018 - "Deletion or antibody-mediated blockade of BAFF receptor ablates B-2 cells and decreases experimental atherosclerosis. " 07/01/2012 - "BAFF receptor deficiency reduces the development of atherosclerosis in mice--brief report." 01/01/2013 - "BAFF receptor mAb treatment ameliorates development and progression of atherosclerosis in hyperlipidemic ApoE(-/-) mice." 07/01/2012 - "The goal of this study was to assess the role of B-cell activating factor (BAFF) receptor in B-cell regulation of atherosclerosis. "
2.	Lymphoma (Lymphomas) 01/01/2012 - "B-cell activation factor (BAFF) and BAFF-receptor (BAFF-R) play crucial roles in the viability and proliferation of malignant lymphoma cells. " 06/01/2006 - "The differential expression of LCK and BAFF-receptor and their role in apoptosis in human lymphomas." 01/01/2019 - "We developed humanized, second-generation CAR T cells against another B cell-specific marker, B cell activating factor receptor (BAFF-R), which demonstrated cytotoxicity against human lymphoma and acute lymphoblastic leukemia (ALL) lines. " 10/01/2020 - "Here we report BAFF engagement to BAFF receptor elicited both priming and activating signals for NLRP3 inflammasomes in primary B cells and B lymphoma cell lines. " 08/01/2014 - "B-cell activating factor-receptor specific activation of tumor necrosis factor receptor associated factor 6 and the phosphatidyl inositol 3-kinase pathway in lymphoma B cells."
3.	Autoimmune Diseases (Autoimmune Disease) 10/01/2005 - "Thus, the dysregulation of BAFF/BAFF receptor system may contribute to induction and development of autoimmune diseases and become one of important therapeutic targets." 01/01/2017 - "Our findings reveal a previously undocumented, dose dependent, immunomodulatory distant effect resulting from BAFF receptor specific mAb-siRNA conjugate treatment in an in vivo model of autoimmune disease." 01/01/2012 - "RP105(-) B cells from active SLE patients express preferentially BCMA (B-cell maturation antigen) compared to BAFF-R (B-cell activating factor-receptor) than normal subjects and other autoimmune diseases. " 12/11/2001 - "Recent studies on BAFF, a member of the tumor necrosis factor family, and the discovery of a new BAFF receptor have revealed that this ligand-receptor pair is essential for B-cell survival and differentiation, holding promise for a better understanding and treatment of some autoimmune diseases and lymphomas."
4.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 07/01/2015 - "Deleting the BAFF receptor TACI protects against systemic lupus erythematosus without extensive reduction of B cell numbers." 04/01/2013 - "To determine the necessity for any individual BAFF receptor in the development of systemic lupus erythematosus (SLE). " 04/01/2013 - "Development of systemic lupus erythematosus in NZM 2328 mice in the absence of any single BAFF receptor." 06/01/2007 - "Decreased B cell activating factor receptor expression on peripheral lymphocytes associated with increased disease activity in primary Sjögren's syndrome and systemic lupus erythematosus." 03/01/2016 - "The objective of this study was to examine the relationship between the expression of B cell activating factor (BAFF) and BAFF receptor in patients with disease activity of systemic lupus erythematosus (SLE). "
5.	Abdominal Aortic Aneurysm 12/01/2021 - "Here, the study examined the effect of selective BAFF antagonism using an anti-BAFF antibody (blocks binding of BAFF to receptors BAFF receptor 3, transmembrane activator and CAML interactor, and B-cell maturation antigen) and mBaffR-mFc (blocks binding of BAFF to BAFF receptor 3) on a murine model of abdominal aortic aneurysm (AAA). "

Related Drugs and Biologics

1.	Ligands
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	Apolipoproteins E (ApoE)
4.	B-Cell Activating Factor
5.	B-Cell Maturation Antigen
6.	Small Interfering RNA (siRNA)
7.	Monoclonal Antibodies
8.	Cyclophilins (Cyclophilin)
9.	Calcium
10.	bis(3- bis(4- chlorophenyl)methyl- 4- dimethylaminophenyl)amine

Related Therapies and Procedures

1.	Therapeutics