Receptor Activator of Nuclear Factor-kappa B (TRANCE-R)

A tumor necrosis factor receptor family member that is specific for RANK LIGAND and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on DENDRITIC CELLS where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

Also Known As:

TRANCE-R; CD265 Antigen; NF-KappaB Receptor Activator; RANK Protein; Receptor Activator of NF-kappa B; Receptor Activator of NF-kappaB; Receptor Activator of Nuclear Factor-kappaB; TNFRSF11A Protein; TRANCE Receptor; Activator, NF-KappaB Receptor; Antigen, CD265; NF Kappa B Receptor Activator; NF KappaB Receptor Activator; Receptor Activator of NF kappa B; Receptor Activator of NF kappaB; Receptor Activator of Nuclear Factor kappa B; Receptor Activator of Nuclear Factor kappaB; Receptor Activator, NF-KappaB; TRANCE R; NF-Kappa B Receptor Activator; Receptors, Tumor Necrosis Factor, Member 11a; Tumor Necrosis Factor Receptor Superfamily, Member 11a

Networked: 379 relevant articles (5 outcomes, 42 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Cytokine Receptors: 1620
        Tumor Necrosis Factor Receptors: 3685
        Receptor Activator of Nuclear Factor-kappa B: 379
        human TNFRSF11A protein
        mouse Tnfrsf11a protein

Experts

1.	Aggarwal, Bharat B: 5 articles (11/2011 - 01/2006)
2.	Dougall, William C: 5 articles (01/2008 - 02/2002)
3.	Yoneda, Toshiyuki: 4 articles (06/2016 - 08/2004)
4.	Roux, Sophie: 4 articles (08/2010 - 02/2002)
5.	Takayanagi, Hiroshi: 4 articles (03/2009 - 01/2005)
6.	Hofbauer, Lorenz C: 4 articles (01/2008 - 08/2002)
7.	Burgués, Octavio: 3 articles (02/2022 - 06/2018)
8.	Cano, Antonio: 3 articles (02/2022 - 06/2018)
9.	Rodríguez-García, Víctor: 3 articles (02/2022 - 06/2018)
10.	Tarín, Juan J: 3 articles (02/2022 - 06/2018)

Related Diseases

1.	Bone Resorption 10/21/2020 - "GTE supplementation also improved bone formation through Bmp2-Smad 1/5/8-Runx2 signaling, while bone resorption was regulated by the receptor activator of nuclear factor kappa-B (RANKL)/osteoprogeterin (OPG) pathway. " 01/06/2014 - "Osteoclasts, responsible for bone resorption, express Receptor Activator of Nuclear factor Kappa B (RANK) receptors. " 11/01/2011 - "Recombinant murine RANK protein effectively inhibits the activity of osteoclasts and the resulting bone resorption." 11/01/2011 - "Murine RANK protein's inhibition of bone resorption." 09/01/2006 - "Receptor activator of nuclear factor-kappaB (RANKL)-mediated osteoclastogenesis plays a pivotal role in inflammatory bone resorption. "
2.	Osteolysis 02/01/2002 - "In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis." 07/01/2018 - "Increasing evidence suggests that receptor activator of nuclear factor kappa-B (NF-κB) ligand-mediated osteoclastogenesis and osteolysis are responsible for wear debris-induced aseptic loosening. " 08/01/2006 - "Signaling of RANK (receptor activator of nuclear factor kappa B) through its ligand RANKL appears critical in osteolysis associated with aseptic loosening (AL). " 02/01/2005 - "TNF-induced receptor activator NF-kappaB ligand (RANKL) synthesis by bone marrow stromal cells is a fundamental component of inflammatory osteolysis. " 11/15/2003 - "More importantly, these I-kappaB mutant forms significantly inhibit in vivo production of TNF and receptor activator of NF-kappaB ligand, and block joint swelling, osteoclast recruitment, and osteolysis. "
3.	Hypercalcemia (Milk Alkali Syndrome) 01/15/2002 - "This study analyzed the expression of various genes that are thought to regulate serum Ca(++) levels in ATL and showed that the overexpression of the receptor activator of nuclear factor kappaB (RANK) ligand gene correlated with hypercalcemia. " 07/01/2007 - "Receptor activator of NF-kappa B ligand inhibition suppresses bone resorption and hypercalcemia but does not affect host immune responses to influenza infection." 03/15/2001 - "Therapeutic efficacy of a soluble receptor activator of nuclear factor kappaB-IgG Fc fusion protein in suppressing bone resorption and hypercalcemia in a model of humoral hypercalcemia of malignancy." 05/01/2019 - "ATL tumor cells uniquely secrete parathyroid hormone-related protein, viral peptides, and inflammatory cytokines, inducing a state of high bone turnover and activation of the receptor activator of nuclear factor kappa-B signaling pathway resulting in hypercalcemia. "
4.	Hypertension (High Blood Pressure) 01/01/2016 - "Amlodipine and atorvastatin improved hypertensive cardiac hypertrophy through regulation of receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B/osteoprotegerin system in spontaneous hypertension rats." 01/01/2016 - "The present study aims to study the role of receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B/osteoprotegerin (RANKL/RANK/OPG) system in cardiac hypertrophy in a spontaneous hypertension rat (SHR) model and the effects of amlodipine and atorvastatin intervention. "
5.	Cardiomegaly (Heart Hypertrophy) 01/01/2016 - "Amlodipine and atorvastatin improved hypertensive cardiac hypertrophy through regulation of receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B/osteoprotegerin system in spontaneous hypertension rats." 01/01/2016 - "The present study aims to study the role of receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B/osteoprotegerin (RANKL/RANK/OPG) system in cardiac hypertrophy in a spontaneous hypertension rat (SHR) model and the effects of amlodipine and atorvastatin intervention. "

Related Drugs and Biologics

1.	Osteoprotegerin
2.	RANK Ligand
3.	Proteins (Proteins, Gene)
4.	Amlodipine (Norvasc)
5.	Atorvastatin (Lipitor)
6.	Titanium
7.	Immunoglobulin G (IgG)
8.	Ligands
9.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
10.	Zoledronic Acid (Zometa)

Related Therapies and Procedures

1.	Therapeutics
2.	Negative-Pressure Wound Therapy
3.	Replacement Arthroplasty
4.	Root Planing
5.	Photochemotherapy (Photodynamic Therapy)