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Death Domain Receptors

A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a death domain due to the fact that many of these receptors are involved in signaling APOPTOSIS. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES.
Also Known As:
Receptors, Death Domain; Death Receptors; Receptors, DR Family; Receptors, Death Domain Family; DR Family Receptors; Domain Receptors, Death; Receptors, Death
Networked: 502 relevant articles (9 outcomes, 34 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. de Jong, Steven: 9 articles (06/2011 - 08/2003)
2. Aggarwal, Bharat B: 8 articles (10/2014 - 08/2009)
3. Hong, Jin Tae: 7 articles (03/2015 - 01/2012)
4. Krammer, Peter H: 7 articles (07/2010 - 04/2004)
5. Ashkenazi, Avi: 6 articles (05/2015 - 03/2002)
6. Zhang, Baolin: 6 articles (03/2015 - 12/2008)
7. Andera, Ladislav: 6 articles (07/2013 - 06/2005)
8. de Vries, Elisabeth G E: 6 articles (06/2011 - 08/2003)
9. Debatin, Klaus-Michael: 6 articles (07/2005 - 07/2003)
10. Fulda, Simone: 5 articles (05/2015 - 07/2003)

Related Diseases

1. Neoplasms (Cancer)
2. Neoplasm Metastasis (Metastasis)
3. Liver Diseases (Liver Disease)
4. Stomach Neoplasms (Stomach Cancer)
5. Ovarian Neoplasms (Ovarian Cancer)

Related Drugs and Biologics

1. Caspases
2. TNF-Related Apoptosis-Inducing Ligand
3. TNF-Related Apoptosis-Inducing Ligand Receptors
4. NF-kappa B (NF-kB)
5. Interferons
6. bortezomib (Velcade)
7. Indicators and Reagents (Reagents)
8. Initiator Caspases
9. Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)
10. Calcitriol (Calcijex)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Ligation
3. Therapeutics
4. Heterologous Transplantation (Xenotransplantation)
5. Bariatric Surgery