|1.||Kallenberg, Cees G M: 20 articles (10/2014 - 01/2002)|
|2.||Stegeman, Coen A: 17 articles (12/2013 - 01/2002)|
|3.||Csernok, Elena: 14 articles (04/2015 - 06/2002)|
|4.||Gross, Wolfgang L: 12 articles (04/2015 - 02/2004)|
|5.||Segelmark, M: 9 articles (02/2014 - 05/2000)|
|6.||Limburg, Pieter C: 9 articles (09/2009 - 02/2002)|
|7.||Limburg, P C: 9 articles (05/2009 - 09/2000)|
|8.||Guillevin, Loïc: 8 articles (11/2015 - 05/2007)|
|9.||Mouthon, Luc: 8 articles (11/2015 - 05/2007)|
|10.||Jenne, Dieter E: 8 articles (08/2014 - 09/2004)|
06/01/2010 - "Longitudinal changes in proteinase 3 (PR3) gene expression were evaluated using reverse transcription-polymerase chain reaction, and clinical outcomes, including remission status and disease activity, were determined using the Birmingham Vasculitis Activity Score for WG (BVAS-WG). "
11/02/2015 - "Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis."
03/01/2013 - "Different murine models have been used as basis for Proteinase 3 (PR3)-associated vasculitis models, but sufficient reproduction of the human clinical manifestation has failed to this date. "
06/15/2009 - "Some patients with vasculitis have elevated plasma levels of neutrophil-derived proteinase 3 (PR3) and anti-PR3 Abs. "
11/01/2003 - "Membrane proteinase 3 expression on resting neutrophils as a pathogenic factor in PR3-ANCA-associated vasculitis."
|2.||Wegener Granulomatosis (Wegener's Granulomatosis)
09/01/2011 - "A substrate-based approach to convert SerpinB1 into a specific inhibitor of proteinase 3, the Wegener's granulomatosis autoantigen."
01/01/2011 - "To analyse whether a specific cytokine pattern is elicited in response to the autoantigen proteinase 3 (PR3) in active Wegener's granulomatosis (WG). "
06/01/2010 - "Transcription of proteinase 3 and related myelopoiesis genes in peripheral blood mononuclear cells of patients with active Wegener's granulomatosis."
01/01/2010 - "Interaction of proteinase 3 with its associated partners: implications in the pathogenesis of Wegener's granulomatosis."
09/01/2009 - "Notably, sera containing anti-proteinase 3 (PR3) from patients with Wegener's granulomatosis reacted in MAIGA. "
|3.||Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
10/01/2007 - "Increased numbers of neutrophils expressing proteinase 3 on their membrane (mPR3) have been reported in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) and are suggested to be involved in AAV immunopathogenesis. "
01/01/2000 - "T lymphocytes from the peripheral blood of patients with ANCA-associated vasculitis have been shown to proliferate in response to proteinase 3 (PR3). "
08/01/2007 - "Furthermore, patients with MPO-ANCA-associated vasculitis (n = 47) were compared with patients with proteinase 3 (PR3)-ANCA associated vasculitis (n = 46). "
07/19/2012 - "These data provide preliminary support for the concept that proteinase 3 ANCA-associated vasculitis and myeloperoxidase ANCA-associated vasculitis are distinct autoimmune syndromes. "
09/01/2011 - "As the proteinase 3 subtype of antineutrophil cytoplasmic antibodies (ANCA) was positive ANCA-associated vasculitis with gastrointestinal, cutaneous and kidney involvement was diagnosed. "
10/29/2009 - "Proteinase 3 (PR3) is an enzyme involved in proteolytic events associated with inflammation. "
09/15/2000 - "Although proteinase 3 (PR3) is known to have the potential to promote inflammation and injure tissues, the biologic forms and function of PR3 in polymorphonuclear neutrophils (PMN) from healthy donors have received little attention. "
06/15/2013 - "Generation of a metabolically stable form of this peptide (CR-AnxA1(2-50)), engineered by substituting a cleavage site shared by human proteinase 3 and neutrophil elastase, yielded an agonist that was resistant to neutrophil-mediated cleavage and displayed enhanced proresolving actions: accelerated resolution of self-limited inflammation and enhanced macrophage efferocytosis after sterile injury, when compared with AnxA1(2-50). "
09/01/2012 - "Proteinase 3, the autoantigen in granulomatosis with polyangiitis, associates with calreticulin on apoptotic neutrophils, impairs macrophage phagocytosis, and promotes inflammation."
07/01/2008 - "Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin."
03/01/2003 - "Although high-avidity PR1-specific T cells killed CML more effectively than low-avidity T cells, only high-avidity T cells underwent apoptosis when stimulated with high PR1 peptide concentration or when exposed to leukemia that overexpressed proteinase 3. No high-avidity PR1-specific T cells could be identified or expanded from newly diagnosed leukemia patients, whereas low-avidity T cells were readily expanded. "
04/15/2001 - "Myeloblastin can confer factor-independent growth to hematopoietic cells, an early step in leukemia transformation. "
02/15/2000 - "Myeloblastin (MBN) initially was described as involved in proliferation of human leukemia cells. "
10/01/1997 - "These results show that PR1-specific allogeneic T cells preferentially inhibit leukemic CFU-GM based on overexpression of proteinase 3, and that proteinase 3-specific CTL could be used for leukemia-specific adoptive immunotherapy."
10/01/1997 - "Analysis by flow cytometry showed that proteinase 3 was overexpressed in the leukemia targets compared with normal marrow targets (median channel fluorescence 1,399 v 298, P = .009). "
|1.||Antineutrophil Cytoplasmic Antibodies (ANCA)
|6.||Myeloblastin (Proteinase 3)
|8.||Pancreatic Elastase (Elastase)
|9.||Peptide Hydrolases (Proteases)
|10.||Messenger RNA (mRNA)
|2.||Stem Cell Transplantation
|4.||Transplantation (Transplant Recipients)