|1.||Kumar, S: 8 articles (11/2015 - 02/2000)|
|2.||Dorstyn, L: 7 articles (11/2015 - 08/2012)|
|3.||Shalini, S: 5 articles (09/2015 - 08/2012)|
|4.||Puccini, J: 5 articles (09/2015 - 08/2012)|
|5.||Dass, Crispin R: 4 articles (09/2014 - 08/2008)|
|6.||Herman, Brian: 4 articles (06/2014 - 10/2006)|
|7.||Kumar, Sharad: 4 articles (01/2014 - 06/2004)|
|8.||Green, Douglas R: 4 articles (09/2009 - 01/2006)|
|9.||Manzl, C: 3 articles (11/2015 - 10/2012)|
|10.||Peintner, L: 3 articles (11/2015 - 10/2012)|
12/03/2013 - "Our recent work indicates that caspase-2 has putative functions in tumor suppression and protection against cellular stress. "
10/15/2011 - "The aim of this study was to explore the possibility that genetic alterations of caspase-2 gene are present in human cancers. "
11/01/2015 - "The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd."
05/01/2015 - "Caspase-2 expression levels are significantly reduced in human lung tumors with wild-type p53, in agreement with the model whereby Caspase-2 functions through Mdm2/p53 regulation. "
05/01/2015 - "In response to DNA damage, Caspase-2 cleaves and inhibits Mdm2 and thereby promotes the stability of the tumor-suppressor p53. "
|2.||Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
09/01/2005 - "In conclusion, low baseline expression of PARP and procaspase-2 is related to cellular drug resistance in childhood acute lymphoblastic leukemia."
09/01/2005 - "Decreased PARP and procaspase-2 protein levels are associated with cellular drug resistance in childhood acute lymphoblastic leukemia."
12/01/1999 - "Caspase 2 and caspase 3 as predictors of complete remission and survival in adults with acute lymphoblastic leukemia."
08/01/2005 - "Caspase-2, PKCdelta, and JNK were furthermore implicated in doxorubicin-induced apoptosis of primary acute lymphoblastic leukemia blasts. "
12/01/1999 - "We hypothesized a similarly significant role for caspase 2 and caspase 3 in patients with acute lymphoblastic leukemia. "
05/01/2012 - "The aim of this study was to explore the neuroprotective efficacy of hypothermia in combination with caspase-2 gene deficiency using the neonatal Rice-Vannucci model of HI injury in mice. "
05/01/2012 - "In conclusion, caspase-2 gene deficiency combined with hypothermia provided enhanced neuroprotection as compared with hypothermia alone."
05/01/2012 - "Delayed hypothermia initiated 2 h after HI in combination with caspase-2 gene deficiency reduced injury in the hippocampus, but not in other brain areas. "
05/01/2012 - "Five hours of hypothermia (33 °C ) vs. normothermia (36 °C) directly after HI provided additive protection overall (temperature P = 0.0004, caspase-2 genotype P = 0.0029), in the hippocampus and thalamus, but not in other gray matter regions or white matter. "
12/01/2003 - "Caspase-2, 3 activities were much higher in the normothermia group [(27.7 +/- 14.7), (94.9 +/- 53.1) pmol/(min.mg protein)] at 24 h post-HI than those of hypothermia [(7.9 +/- 3.4), (21.1 +/- 18.7) pmol/(min.mg protein)] and normal control groups [(7.6 +/- 0.7), (12.9 +/- 0.5) pmol/(min x mg protein)] (P < 0.01). "
|4.||Optic Nerve Injuries
01/01/2011 - "In a rat model of optic nerve transection, in which 80% of RGCs are eliminated within 14 days, caspase-2 was found to be expressed and cleaved (activated) predominantly in RGC. "
01/01/2011 - "Our results indicate that RGC apoptosis induced by optic nerve injury involves activation of caspase-2, and that synthetic siRNAs designed to inhibit expression of caspase-2 represent potential neuroprotective agents for intervention in human diseases involving RGC loss."
06/01/2004 - "In the current study, we analyzed the expression of caspase-2, -6 and -7 in 120 gastric carcinomas by immunohistochemistry using a tissue microarray approach. "
07/01/2013 - "miR-708 promotes the development of bladder carcinoma via direct repression of Caspase-2."
07/20/2005 - "And caspase-2 protein expression was becoming weaker along with the development of carcinoma (P < 0.01 or P < 0.05). "
10/15/2011 - "In this study, we analyzed the entire coding sequences of human caspase-2 gene for the detection of somatic point mutations in 90 gastric carcinomas and 100 colorectal carcinomas by polymerase chain reaction (PCR)-single strand conformation polymorphism (SSCP). "
03/01/2013 - "Importance of transcript levels of caspase-2 isoforms S and L for breast carcinoma progression."
|1.||Caspase 3 (Caspase-3)
|2.||Caspase 8 (Caspase-8)
|3.||Messenger RNA (mRNA)
|4.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|9.||Protein Isoforms (Isoforms)
|1.||Drug Therapy (Chemotherapy)
|4.||Transplantation (Transplant Recipients)