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Caspase 2

A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
Also Known As:
Caspase 2 Subunit p12; Caspase 2 Subunit p13; Caspase 2 Subunit p18; Caspase-2; ICH-1 Protease; Pro-Caspase-2; Procaspase-2; ICH 1 Protease; Pro Caspase 2; Procaspase 2
Networked: 198 relevant articles (4 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Kumar, S: 8 articles (11/2015 - 02/2000)
2. Dorstyn, L: 7 articles (11/2015 - 08/2012)
3. Shalini, S: 5 articles (09/2015 - 08/2012)
4. Puccini, J: 5 articles (09/2015 - 08/2012)
5. Dass, Crispin R: 4 articles (09/2014 - 08/2008)
6. Herman, Brian: 4 articles (06/2014 - 10/2006)
7. Kumar, Sharad: 4 articles (01/2014 - 06/2004)
8. Green, Douglas R: 4 articles (09/2009 - 01/2006)
9. Manzl, C: 3 articles (11/2015 - 10/2012)
10. Peintner, L: 3 articles (11/2015 - 10/2012)

Related Diseases

1. Neoplasms (Cancer)
2. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
3. Hypothermia
4. Optic Nerve Injuries
5. Carcinoma (Carcinomatosis)

Related Drugs and Biologics

1. Caspase 3 (Caspase-3)
2. Caspase 8 (Caspase-8)
3. Messenger RNA (mRNA)
4. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5. Caspases
6. Paclitaxel (Taxol)
7. Taxoids
8. Apigenin
9. Protein Isoforms (Isoforms)
10. Thapsigargin

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Axotomy
3. Transplants (Transplant)
4. Transplantation (Transplant Recipients)
5. Therapeutics