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Caspase 2

A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
Also Known As:
Caspase 2 Subunit p12; Caspase 2 Subunit p13; Caspase 2 Subunit p18; Caspase-2; ICH-1 Protease; Pro-Caspase-2; Procaspase-2; ICH 1 Protease; Pro Caspase 2; Procaspase 2
Networked: 307 relevant articles (6 outcomes, 33 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Kumar, S: 10 articles (11/2017 - 02/2000)
2. Dorstyn, L: 9 articles (11/2017 - 08/2012)
3. Ashe, Karen H: 7 articles (09/2022 - 11/2016)
4. Kumar, Sharad: 7 articles (01/2019 - 06/2004)
5. Puccini, J: 7 articles (11/2017 - 08/2012)
6. Zhivotovsky, Boris: 6 articles (06/2022 - 08/2005)
7. Dorstyn, Loretta: 6 articles (01/2019 - 03/2009)
8. Shalini, S: 6 articles (10/2016 - 08/2012)
9. Nelson, Kathryn M: 5 articles (09/2022 - 01/2019)
10. Eberhardt, Wolfgang: 5 articles (04/2022 - 01/2017)

Related Diseases

1. Neoplasms (Cancer)
2. Neuroblastoma
3. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
4. Hypothermia
5. Melanoma (Melanoma, Malignant)

Related Drugs and Biologics

1. Caspase 3 (Caspase-3)
2. Inflammasomes
3. Caspases
4. Messenger RNA (mRNA)
5. Cytochromes c (Cytochrome c)
6. Paclitaxel (Taxol)
7. Proteins (Proteins, Gene)
8. Caspase 8 (Caspase-8)
9. Caspase 9
10. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Ophthalmic Administration
4. Intravitreal Injections
5. Axotomy