|1.||Kidney Diseases (Kidney Disease)
|3.||Vitamin B 12 Deficiency (Vitamin B12 Deficiency)
|4.||Spinal Cord Diseases
|5.||Neurologic Manifestations (Neurological Manifestations)
|1.||Scalabrino, Giuseppe: 5 articles (01/2007 - 06/2002)|
|2.||Jaiser, Stephan R: 4 articles (11/2012 - 07/2008)|
|3.||Winston, Gavin P: 4 articles (11/2012 - 07/2008)|
|4.||Kumar, Neeraj: 3 articles (04/2012 - 07/2004)|
|5.||Linnebank, M: 2 articles (01/2015 - 10/2006)|
|6.||Mutti, Elena: 2 articles (01/2007 - 11/2003)|
|7.||Veber, Daniela: 2 articles (01/2007 - 11/2003)|
|8.||Huang, Jimmy: 1 article (12/2015)|
|9.||Morioka, Craig: 1 article (12/2015)|
|10.||Zamani, Amir: 1 article (12/2015)|
|1.||Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric
01/01/2010 - "Shortly thereafter the therapeutic efficacy of vitamin B(12) on subacute combined degeneration was demonstrated by West and Reisner and others. "
05/01/2014 - "The main purpose of our study was to evaluate morphometric and microstructural changes in the brain and relate them to cognition in subacute combined degeneration of the spinal cord and patients with biochemically deficient vitamin B12. "
05/01/1988 - "Central and peripheral nerve conduction was studied in two patients with subacute combined degeneration by using the short-latency somatosensory evoked potentials and the peripheral nerve conduction study during treatment with cyanocobalamin. "
01/01/1979 - "Subacute combined degeneration of the spinal cord and the vitamin B12 metabolism, a clinical study."
01/01/2015 - "He also had a history of subacute combined degeneration of the spinal cord since the age of 67, which was successfully treated with vitamin B12 therapy. "
|2.||Folic Acid (Vitamin M)FDA LinkGeneric
01/15/2014 - "Folate deficiency is known to be associated with subacute combined degeneration of the spinal cord; however, reports of long-standing cases are rare. "
11/01/1995 - "Subacute combined degeneration of the spinal cord is a rare neurologic complication of folate deficiency. "
11/01/1995 - "Case report: subacute combined degeneration of the spinal cord from folate deficiency."
06/01/1990 - "Subacute combined degeneration of the cord which occurred as a result of dietary deficiency of folic acid in a patient with a psychotic illness, is described. "
06/01/1990 - "Subacute combined degeneration of the spinal cord due to folate deficiency in association with a psychotic illness."
|3.||Nitrous Oxide (Laughing Gas)IBA
01/01/2013 - "Subacute combined degeneration of the spinal cord following recreational nitrous oxide use."
06/01/2011 - "Iatrogenic usage of nitrous oxide apparently resulted in subacute combined degeneration in our three patients. "
06/01/2011 - "Subacute combined degeneration of the spinal cord was diagnosed and the etiology was considered related to nitrous oxide misuse. "
06/01/2011 - "Case reports with a comprehensive review of the current literature concerning subacute combined degeneration induced by nitrous oxide inhalation. "
06/01/2011 - "Subacute combined degeneration caused by nitrous oxide intoxication: case reports."
07/01/2008 - "Subacute combined degeneration due to copper deficiency."
10/01/2007 - "There is growing clinical evidence supporting a connection between copper deficiency and subacute combined degeneration. "
10/01/2007 - "Subacute combined degeneration due to copper deficiency."
02/01/2010 - "Acquired copper deficiency can cause a clinical picture that mimics the subacute combined degeneration seen with vitamin B (12) deficiency. "
09/01/2008 - "Neurological manifestations due to copper deficiency include ataxic myeloneuropathy that resembles subacute combined degeneration due to B12 deficiency. "
02/01/1974 - "[Psychic symptoms in vitamin B12-deficiency with subacute combined degeneration of the spinal cord (author's transl)]."
03/01/2011 - "The diagnosis was difficult in this case because the patient did not show the typical symptoms and complications associated with vitamin B₁₂ deficiency, such as megaloblastic anemia, or subacute combined degeneration of the spinal cord. "
10/01/1970 - "Although patients with pernicious anaemia, some with subacute combined degeneration of the cord, have been studied, emphasis in the discussion is placed on the significantly increased excretion of the radioactive vitamin in a group of patients with pituitary insufficiency. "
01/27/1951 - "Effect of vitamin B12c in pernicious anemia and subacute combined degeneration of the cord."
03/01/2011 - "[A case presenting with ataxic gait and dementia due to vitamin B₁₂ deficiency without megaloblastic anemia or subacute combined degeneration of the spinal cord]."
|6.||Methionine (L-Methionine)FDA Link
12/01/2015 - "Specifically, significant evidence suggests that dysfunctional methionine metabolism as well as dysregulated cytokine production secondary to B12 deficiency play a major role in the development of subacute combined degeneration. "
03/01/1991 - "Similarities were noted with the changes described in subacute combined degeneration of the spinal cord in human beings, a neuropathy caused by methionine and methylation deficiency in patients with vitamin B12 deficiency. "
08/01/1992 - "Methionine may be an important first-line therapy in the initial treatment of neuropathy and myeloneuropathy induced by nitrous oxide, and has a hypothetical role in the treatment of subacute combined degeneration of the cord."
08/15/1981 - "This explains why administration of folic acid, which induces cell division and use of methionine in protein synthesis, impairs methylation of myelin and precipitates or exacerbates subacute combined degeneration (SCD). "
08/15/1981 - "A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid induced exacerbation of subacute combined degeneration in pernicious anaemia."
01/01/2015 - "Surprisingly, further testing including methylmalonic acid (3732 nmol/L, normal<271) and homocysteine (48.5 µmol/L, normal<10) showed an impairment of vitamin B12-dependent metabolism leading to the diagnosis of subacute combined degeneration. "
10/01/2006 - "We report the successful oral treatment of subacute combined degeneration of the spinal cord in a 24-year-old woman closely monitored clinically with MRI and plasma levels of vitamin B12, homocysteine, and methylmalonic acid. "
01/01/2015 - "Herein, we report a case of a 20-year-old (ethnicity not reported) woman with a history of nitrous oxide abuse and clinical symptoms consistent with spinal cord subacute combined degeneration with associated low serum concentrations of vitamin B12, elevated methylmalonic acid levels, and radiologic evidence of demyelination of the dorsal region of the spinal column. "
|8.||Methotrexate (Mexate)FDA LinkGeneric
07/01/2013 - "Methotrexate-induced myelopathy mimicking subacute combined degeneration of the spinal cord."
08/01/2014 - "Myelopathy mimicking subacute combined degeneration in a Down syndrome patient with methotrexate treatment for B lymphoblastic leukemia: report of an autopsy case."
02/01/2015 - "The authors report a case of a 15-year-old boy with Burkitt leukemia who developed progressive myelopathy after intrathecal triple therapy (methotrexate, cytarabine, and hydrocortisone) whose clinical and radiologic features were compatible with subacute combined degeneration. "
06/01/1992 - "Cycloleucine (CL), an inhibitor of methionine adenosyltransferase, has previously been used to produce an experimental model of subacute combined degeneration of the spinal cord. "
01/01/1986 - "Cells treated with 30 microM sinefungin, which inhibits myelin basic protein methyltransferase in broken cell preparations about 60%, produced ringlike structures that were devoid of multilamellar periodicity and compactness reminiscent of the vacuolated myelin observed in subacute combined degeneration and in nitrous-oxide- or cycloleucine-treated animals in which methyltransferase activity is also inhibited. "
06/01/1993 - "Cycloleucine, tellurium, and 1,3-dinitrobenzene provide models of subacute combined degeneration, primary peripheral nerve demyelination, and thiamine deficiency-like lesions, respectively. "
|10.||Pyruvic Acid (Pyruvate)IBA
11/09/1963 - "SUBACUTE COMBINED DEGENERATION OF THE CORD AFTER PARTIAL GASTRECTOMY."
11/19/1960 - "Subacute combined degeneration of the cord after partial gastrectomy."
02/01/2000 - "We present a case of vitamin B12 deficiency and subacute combined degeneration in a patient with a gastrectomy. "
11/01/2003 - "Over the last few years we have reproduced all of the key morphological and biochemical features of human subacute combined degeneration in the central nervous system and peripheral nervous system of rats made cobalamin-deficient by means of total gastrectomy or a chronic cobalamin-deficient diet. "
06/01/2013 - "We diagnosed him with subacute combined degeneration on the evidence of history of gastrectomy, lower normal limit of vitamin B12 (363 pg/ml), apparent absence of vibration sensations and paresthesia in the feet. "
|2.||Drug Therapy (Chemotherapy)
02/01/2015 - "Progressive myelopathy mimicking subacute combined degeneration after intrathecal chemotherapy."
05/01/2013 - "Chemotherapy-related myelopathy mimicking subacute combined degeneration (SCD) has rarely been reported. "
04/01/2007 - "MR findings of intrathecal chemotherapy-related myelopathy in two cases: mimicker of subacute combined degeneration."
12/01/1993 - "Five cases (four from the literature and one new case) are presented in which patients unsuspected of having vitamin B12 deficiency developed subacute combined degeneration of the spinal cord following nitrous oxide anesthesia. "
01/01/2005 - "Cobalamin deficiency and subacute combined degeneration after nitrous oxide anesthesia: a case report."
06/01/1998 - "We describe a patient with unsuspected cobalamin deficiency who developed subacute combined degeneration of the spinal cord after nitrous oxide anesthesia. "
|4.||Vegetarian Diet (Vegetarianism)
07/01/2001 - "Reversible subacute combined degeneration of the spinal cord in a 14-year-old due to a strict vegan diet."
03/01/2009 - "Subacute combined degeneration (SCD) of the spinal cord is the most common neurologic manifestation of vitamin B12 (cobalamin) deficiency and is usually secondary to autoimmune gastritis, but may also be seen in malnutrition syndromes such as chronic alcoholism, strict vegetarianism, gastrectomy, and also in nitrous oxide abuse. "
03/01/2001 - "To observe the presentations and in the patients with subacute combined degeneration (SCD) changes of electrophysiology (EP) and magnetic resonance image (MRI) before and after treatment and to analyze their values in diagnosis. "
05/01/1988 - "Before and after treatment of subacute combined degeneration."