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Familial Partial Lipodystrophy (Dunnigan Syndrome)

Inherited conditions characterized by the partial loss of ADIPOSE TISSUE, either confined to the extremities with normal or increased fat deposits on the face, neck and trunk (type 1), or confined to the loss of SUBCUTANEOUS FAT from the limbs and trunk (type 2). Type 3 is associated with mutation in the gene encoding PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA.
Also Known As:
Dunnigan Syndrome; Lipodystrophy, Familial Partial; Familial Partial Lipodystrophy, Kobberling Type; Familial Partial Lipodystrophy, Type 1; Familial Partial Lipodystrophy, Type 2; Familial Partial Lipodystrophy, Type 3; Koberling-Dunnigan Syndrome; Lipodystrophy, Familial Partial, Associated With PPARg Mutations; Lipodystrophy, Familial Partial, Dunnigan Type; Lipodystrophy, Familial Partial, Kobberling Type; Lipodystrophy, Familial Partial, Type 1; Lipodystrophy, Familial Partial, Type 2; Lipodystrophy, Familial Partial, Type 3; Lipodystrophy, Familial, of Limbs and Lower Trunk; Lipodystrophy, Reverse Partial; Familial Partial Lipodystrophies; Koberling Dunnigan Syndrome; Partial Lipodystrophies, Reverse; Partial Lipodystrophy, Familial; Partial Lipodystrophy, Reverse; Reverse Partial Lipodystrophies; Reverse Partial Lipodystrophy
Networked: 176 relevant articles (11 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Hypertriglyceridemia
2. Diabetes Mellitus
3. Ovarian Hyperstimulation Syndrome
4. Cysts
5. Lipodystrophy

Experts

1. Vigouroux, Corinne: 14 articles (01/2020 - 01/2003)
2. Hegele, Robert A: 12 articles (12/2014 - 03/2002)
3. Hegele, R A: 10 articles (10/2006 - 01/2000)
4. Garg, Abhimanyu: 9 articles (02/2019 - 01/2002)
5. Capeau, Jacqueline: 7 articles (01/2017 - 01/2003)
6. Lascols, O: 7 articles (05/2014 - 11/2000)
7. Vigouroux, C: 7 articles (05/2014 - 11/2000)
8. Cao, H: 7 articles (10/2006 - 01/2000)
9. Lascols, Olivier: 6 articles (12/2019 - 06/2005)
10. Worman, Howard J: 6 articles (01/2017 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Familial Partial Lipodystrophy:
1. Pioglitazone (Actos)FDA Link
2. LeptinIBA
3. metreleptinIBA
4. Peroxisome Proliferator-Activated Receptors (PPAR)IBA
5. Rosiglitazone (Avandia)FDA Link
6. Gonadotropin-Releasing Hormone (GnRH)FDA Link
7. monoaminocarboxydihydroboraneIBA
8. Lamin Type A (Lamin A)IBA
9. Proteins (Proteins, Gene)FDA Link
10. prelamin AIBA

Therapies and Procedures

1. Therapeutics
2. Caloric Restriction
3. Injections
4. Gastric Bypass (Roux-en-Y Gastric Bypass)
5. Highly Active Antiretroviral Therapy (HAART)