Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)

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1361 relevant articles (124 outcomes, 281 trials/studies) found for this Bio-Agent

Description: A subclass of cyclooxygenase inhibitors with specificity for CYCLOOXYGENASE-2.

Also Known As:

COX-2 Inhibitors; Cyclooxygenase-2 Inhibitors; COX2 Inhibitors; Coxibs; 2 Inhibitors, Cyclooxygenase; COX 2 Inhibitors; Inhibitors, COX-2; Inhibitors, COX2; Inhibitors, Cyclooxygenase 2; Inhibitors, Cyclooxygenase-2

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses

Pharmacologic Actions: 50

Therapeutic Uses: 189

Anti-Inflammatory Agents: 1135

Non-Steroidal Anti-Inflammatory Agents: 5329

Cyclooxygenase Inhibitors: 348

Cyclooxygenase 2 Inhibitors: 1361

Molecular Mechanisms of Pharmacological Action: 5

Enzyme Inhibitors: 590

Cyclooxygenase Inhibitors: 348

Cyclooxygenase 2 Inhibitors: 1361

Physiological Effects of Drugs: 1

Peripheral Nervous System Agents

Sensory System Agents

Analgesics: 5442

Non-Narcotic Analgesics: 378

Non-Steroidal Anti-Inflammatory Agents: 5329

Cyclooxygenase Inhibitors: 348

Cyclooxygenase 2 Inhibitors: 1361

Experts

1.	Laupacis, Andreas: 4 articles (12/2006 - 02/2003)
2.	Mamdani, Muhammad: 4 articles (12/2006 - 02/2003)
3.	Watson, Douglas J: 3 articles (05/2007 - 05/2004)
4.	Ruschitzka, Frank: 3 articles (03/2007 - 11/2003)
5.	Kopp, Alex: 3 articles (12/2006 - 02/2003)
6.	Sabichi, Anita L: 3 articles (02/2006 - 01/2003)
7.	Schwarz, Markus J: 3 articles (04/2005 - 08/2004)
8.	Müller, Norbert: 3 articles (04/2005 - 08/2004)
9.	Riedel, Michael: 3 articles (04/2005 - 08/2004)
10.	Juurlink, David N: 3 articles (01/2005 - 02/2003)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2007 - "Results confirming that COX-2 blockade is effective for both cancer prevention and therapy have been tempered by observations that some COX2 inhibitors pose a risk to the cardiovascular system, and more studies are needed in order to determine if certain of these drugs can be taken at dosages that prevent cancer without increasing cardiovascular risk" 05/01/2005 - "OBJECTIVES: Preclinical observations that selective cyclooxygenase-2 inhibitors enhance in vitro cell radiosensitivity and in vivo tumor radioresponse led to clinical trials testing therapeutic efficacy of these agents" 02/01/2003 - "Selective COX-2 inhibitors appear to be sufficiently safe to permit large-scale clinical testing and numerous clinical trials are currently under way to determine whether selective inhibitors of COX-2 are effective in the prevention and treatment of cancer." 03/01/2008 - "These results show that alternative classes of COX-2 inhibitors may likely be efficacious as cancer chemopreventive agents and may have an improved therapeutic index." 01/01/2008 - "This novel observation may have therapeutic implications such that COX-2 inhibitors may improve therapeutic efficacy of radiation even in patients whose tumor radioresistance is not dependent on COX-2." Get all the results and reference details, order at left...
2.	Pain (Aches) 03/01/2007 - "These results illustrate that COX-2 may indeed play an important role in the maintenance of neuropathic pain following nerve injury, but that only certain COX-2 inhibitors, such as GW406381, are effective in this paradigm" 08/01/2008 - "Recent studies have demonstrated an important role of cyclooxygenase-2 inhibitors in the management of acute pain processes" 02/01/2005 - "This supports the hypothesis that coxibs may act, in part, in the human CNS, provide important new information on the mechanism and treatment of pain and may guide coxib selection for therapeutic trials when CNS penetration is desirable." 05/01/2004 - "Thirty-three studies included 62 comparisons of the four COX-2 inhibitors with placebo and the COX-2 inhibitors significantly decreased post-operative pain" 08/01/2008 - "Future investigations that include different multimodal techniques, for example combining cyclooxygenase-2 inhibitors with regional blocks, may help elucidate and clarify the true benefits of perioperative cyclooxygenase-2 inhibitors in acute pain management strategies." Get all the results and reference details, order at left...
3.	Inflammation 12/01/2004 - "CONCLUSION: Although beneficial in the treatment of pathological inflammation, selective COX-2 inhibitors may adversely affect colonic anastomotic healing." 05/01/2003 - "To elucidate the complex role of inflammation in neurodegenerative processes and the efficacy of selective COX-2 inhibitors in AD, we examined whether the attenuation of brain inflammatory reaction by selective COX-2 inhibitors may protect neurons against neurodegeneration" 01/01/2002 - "Given the intrathecal potency of COX-2 inhibitors, the comparable efficacy of intrathecal versus systemic COX-2 inhibitors in hyperalgesic states not associated with inflammation, and the onset of antihyperalgesic activity prior to COX-2 upregulation, it is argued that a principal antihyperalgesic mechanism of COX-2 inhibitors lies with modulation of constitutive COX-2 present at the spinal level." 02/27/2003 - "Our study suggests an important molecular mechanism by which COX-2 inhibitors reduce inflammation and suppress carcinogenesis in gastrointestinal tract." 06/01/2007 - "The interaction between inflammation and BPH has not yet been clarified, but anti-inflammatory drugs appear to improve symptoms and may have a place in short-term treatment of BPH, as their long-term use is not recommended and COX-2 inhibitors have been withdrawn from the market" Get all the results and reference details, order at left...
4.	Colorectal Neoplasms (Colorectal Cancer) 06/01/2000 - "Recent data obtained in animal studies suggest that COX-2 inhibitors may also be useful in the treatment of established colorectal tumors" 12/15/2005 - "The current study highlights a novel mechanism to circumvent colorectal carcinoma cell resistance to TRAIL-mediated apoptosis using COX-2 inhibitors to manipulate the lipid metabolism within the plasma membrane." 10/01/2003 - "Large clinical studies have shown chemopreventive activity of coxibs in colorectal cancer" 06/01/2003 - "Large retrospective and prospective population-based studies have shown that the use of both nonselective, nonsteroidal anti-inflammatory drugs and selective COX-2 inhibitors are associated with decreased colorectal cancer incidence and mortality rate" 10/01/2001 - "Recent studies in humans indicate that therapy with specific COX-2 inhibitors might be an effective approach to colorectal cancer prevention and treatment." Get all the results and reference details, order at left...
5.	Breast Neoplasms (Breast Cancer) 02/01/2007 - "Furthermore, AQUA and X-tile analysis suggest an optimal cutpoint that may be helpful in future investigations of Cox-2 and specifically, in studies looking at its expression as a predictive biomarker in clinical trials of Cox-2 inhibitors in breast cancer." 01/01/2003 - "Thus, selective COX-2 inhibitors offer considerable promise for the prevention and treatment of human breast cancer." 06/01/2001 - "Importantly, several recent studies of mammary tumorigenesis in animal models have found selective COX-2 inhibitors to be effective in the prevention and treatment of breast cancer" 09/01/2003 - "The present findings support the efforts to initiate clinical trials on the efficacy of COX-2 inhibitors in adjuvant treatment of breast cancer." 02/01/2002 - "The present findings support efforts to initiate clinical trials on the efficacy of Cox-2 inhibitors in adjuvant treatment of breast cancer." Get all the results and reference details, order at left...
273 Diseases and 1361 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
2.	Aspirin (Acetylsalicylic Acid)
3.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
4.	celecoxib (Celebrex)
5.	rofecoxib (Vioxx)
6.	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)
7.	Ibuprofen (Motrin)
8.	Anti-Inflammatory Agents (Anti-Inflammatories)
9.	Cyclooxygenase 2 (Cyclooxygenase-2)
10.	prexige (lumiracoxib)
320 Drugs and Important Bio-Agents and 701 more articles analyzed in the Research Interface, order at left...

Related Therapies and Procedures

1.	Chemoprevention
2.	Prostatectomy (Retropubic Prostatectomy)
3.	Analgesia
4.	Infusion Pumps (Infusion Pump)
5.	Homeopathy
25 Therapies and Procedures and 135 more articles analyzed in the Research Interface, order at left...

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