Fanconi Anemia Complementation Group C Protein

A Fanconi anemia complementation group protein that regulates the activities of CYTOCHROME P450 REDUCTASE and GLUTATHIONE S-TRANSFERASE. It is found predominately in the CYTOPLASM, but moves to the CELL NUCLEUS in response to FANCE PROTEIN.

Also Known As:

Networked: 6 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Buskwofie, Ama: 1 article (01/2019)
2.	Caputo, Thomas: 1 article (01/2019)
3.	Carlson, Ann D: 1 article (01/2019)
4.	Chapman-Davis, Eloise: 1 article (01/2019)
5.	Fields, Jessica C: 1 article (01/2019)
6.	Frey, Melissa K: 1 article (01/2019)
7.	Holcomb, Kevin: 1 article (01/2019)
8.	Kopparam, Rohini V: 1 article (01/2019)
9.	Ni Zhou, Zhen: 1 article (01/2019)
10.	Clapp, D Wade: 1 article (05/2016)

Related Diseases

1.	Fanconi Anemia (Fanconi's Anemia) 07/01/2000 - "Mice mutant for the Fanconi anemia complementation group C locus (Fancc) have reduced germ cell numbers as early as embryonic day E12.5, suggesting the Fancc protein functions prior to meiosis in both sexes. " 01/01/2014 - "The Fanconi anemia group C protein (FANCC) is one of the several proteins that comprise the Fanconi anemia (FA) network involved in genomic surveillance. " 05/05/2016 - "Fanconi anemia complementation group C (FANCC) protein interacts with Parkin, is required in vitro and in vivo for clearance of damaged mitochondria, and decreases mitochondrial reactive oxygen species (ROS) production and inflammasome activation. The mitophagy function of FANCC is genetically distinct from its role in genomic DNA damage repair. " 10/01/2002 - "Here we demonstrate that retroviral transduction of Fanconi anemia subtype E (FA-E) cells with the FANCE cDNA restores the nuclear accumulation of FANCC protein, FANCA-FANCC complex formation, monoubiquitination and nuclear foci formation of FANCD2, and mitomycin C resistance. " 12/15/2000 - "Therefore fas-induced apoptosis in Fanconi anemia cells of the C type involves the activation of caspase 8, which controls activation of caspase 3 family members and one direct or indirect function of the FANCC protein is to suppress apoptotic responses to IFN-gamma upstream of caspase 3 activation. "
2.	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 01/01/2019 - "Non-BRCA1/2 cancer-associated genes harboring mutations included RAD51D, TP53, mutS homolog 6 (MSH6), checkpoint kinase 2 (CHEK2), adenomatous polyposis coli (APC), and Fanconi anemia group C protein (FANCC). "
3.	Neoplasms (Cancer) 01/01/2019 - "Non-BRCA1/2 cancer-associated genes harboring mutations included RAD51D, TP53, mutS homolog 6 (MSH6), checkpoint kinase 2 (CHEK2), adenomatous polyposis coli (APC), and Fanconi anemia group C protein (FANCC). "

Related Drugs and Biologics

1.	Inflammasomes
2.	Reactive Oxygen Species (Oxygen Radicals)
3.	Checkpoint Kinase 2
4.	Caspase 8 (Caspase-8)
5.	Caspase 3 (Caspase-3)
6.	Complementary DNA (cDNA)
7.	Mitomycin (Mitomycin-C)
8.	Proteins (Proteins, Gene)
9.	MutS Proteins