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Type I Bone Morphogenetic Protein Receptors

A subtype of bone morphogenetic protein receptors with high affinity for BONE MORPHOGENETIC PROTEINS. They can interact with and undergo PHOSPHORYLATION by BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II. They signal primarily through RECEPTOR-REGULATED SMAD PROTEINS.
Also Known As:
Bone Morphogenetic Protein Receptors, Type I; Activin Receptor-Like Kinase 3; Activin Receptor-Like Kinase 6; BMP Type I Receptor; BMP Type IA Receptor; BMP Type IB Receptor; BMPR-I Receptors; BMPR-IA Receptor; BMPR-IB Receptor; Bone Morphogenetic Protein Receptor Type I; Bone Morphogenetic Protein Receptor, Type IA; Bone Morphogenetic Protein Receptor, Type IB; Serine-Threonine Protein Kinase Receptor R6; Type IA Bone Morphogenetic Protein Receptor; Type IB Bone Morphogenetic Protein Receptor; Activin Receptor Like Kinase 3; Activin Receptor Like Kinase 6; BMPR I Receptors; BMPR IA Receptor; BMPR IB Receptor; Serine Threonine Protein Kinase Receptor R6
Networked: 65 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Kaplan, Frederick S: 14 articles (01/2022 - 05/2006)
2. Shore, Eileen M: 13 articles (11/2020 - 05/2006)
3. Mishina, Yuji: 10 articles (12/2021 - 03/2005)
4. Yu, Paul B: 7 articles (11/2016 - 12/2008)
5. Pignolo, Robert J: 6 articles (01/2022 - 11/2011)
6. Komatsu, Yoshihiro: 4 articles (12/2021 - 06/2013)
7. Pan, Haichun: 4 articles (12/2021 - 06/2013)
8. Ten Dijke, Peter: 4 articles (06/2021 - 01/2010)
9. van Dinther, Maarten: 4 articles (06/2021 - 01/2010)
10. Bullock, Alex N: 4 articles (11/2019 - 06/2013)

Related Diseases

1. Prostatic Neoplasms (Prostate Cancer)
2. Neoplasm Metastasis (Metastasis)
3. Hypoxia (Hypoxemia)
4. Myositis Ossificans (Fibrodysplasia Ossificans Progressiva)
5. Heterotopic Ossification (Ectopic Ossification)
01/01/2012 - "The ACVR1/Alk-2 gene, encoding a BMP type I receptor, is mutated in Fibrodysplasia Ossificans Progressiva, a severe form of heterotopic ossification. "
06/01/2011 - "The discovery that mildly activating mutations in ACVR1/ALK2, a bone morphogenetic protein (BMP) type I receptor, is the cause of FOP has provided opportunities to identify previously unknown functions for this receptor and for BMP signaling and to develop new diagnostic and therapeutic strategies for FOP and other more common forms of heterotopic ossification, as well as tissue engineering applications."
12/01/2008 - "These results support the role of dysregulated ALK2 kinase activity in the pathogenesis of FOP and suggest that small molecule inhibition of BMP type I receptor activity may be useful in treating FOP and heterotopic ossification syndromes associated with excessive BMP signaling."
01/01/2023 - "A R206H mutation in the human (hs) BMP type I receptor hsACVR1, on the other hand, leads to excessive phosphorylation of Sons of mothers against decapentaplegic (SMAD) 1/5/8. This in turn causes increased inflammation and heterotopic ossification in soft tissues of patients suffering from Fibrodysplasia Ossificans Progressiva (FOP). "
01/01/2018 - "Individuals with the rare developmental disorder fibrodysplasia ossificans progressiva (FOP) experience disabling heterotopic ossification caused by a gain of function mutation in the intracellular region of the BMP type I receptor kinase ALK2, encoded by the gene ACVR1. "

Related Drugs and Biologics

1. Activins (Activin)
2. LDN 193189
3. Type II Bone Morphogenetic Protein Receptors (Bone Morphogenetic Protein Receptor Type II)
4. Bone Morphogenetic Proteins (Bone Morphogenetic Protein)
5. Phosphotransferases (Kinase)
6. Activin Receptors (Activin Receptor)
7. activin A
8. Hepcidins
9. Serine (L-Serine)
10. Phosphoric Monoester Hydrolases (Phosphatases)

Related Therapies and Procedures

1. Therapeutics
2. Sutures (Suture)