|1.||Cremasco, Viviana: 4 articles (03/2010 - 06/2008)|
|2.||Faccio, Roberta: 4 articles (03/2010 - 06/2008)|
|3.||Kassis, J: 3 articles (05/2007 - 04/2001)|
|4.||Wells, A: 3 articles (05/2007 - 04/2001)|
|5.||Katan, Matilda: 2 articles (08/2009 - 04/2005)|
|6.||Yu, Philipp: 2 articles (08/2009 - 04/2005)|
|7.||Bunney, Tom D: 2 articles (08/2009 - 04/2005)|
|8.||Fuchs, Helmut: 2 articles (08/2009 - 04/2005)|
|9.||Auger, Jocelyn M: 2 articles (07/2009 - 05/2008)|
|10.||Watson, Steve P: 2 articles (07/2009 - 05/2008)|
07/15/2005 - "Why PLCgamma2 is more important than PLCgamma1 for NK cell activation and whether PLCgamma2 is also critical for NK cell development, secretion of IFN-gamma, and clearance of viral infections in vivo is not known. "
07/15/2005 - "Consequently, mice lacking PLCgamma2 controlled murine CMV infection substantially less effectively than did wild-type animals, and this defect was most evident in the spleen, where viral clearance mostly depends on NK cell lytic function. "
03/15/1995 - "TCR/CD3-induced tyrosine phosphorylation of the intracellular enzyme phospholipase-C gamma 1 and the surface receptor/substrates CD5 and CD6 was unaffected by virus infection, whereas augmented responses normally observed after the co-ligation of CD4 with TCR/CD3 on T lymphocytes were absent in HIV-1-infected H9 cells. "
12/01/2009 - "Activated Akt binds and phosphorylates PLC(gamma) before Akt targets the tumor suppressor Chfr. "
05/17/2001 - "Dolichol-phosphate-mannose-3 (DPM3)/prostin-1 is a novel phospholipase C-gamma regulated gene negatively associated with prostate tumor invasion."
08/01/1999 - "A role for phospholipase C-gamma-mediated signaling in tumor cell invasion."
03/01/1999 - "These results support a key role for PLC-gamma activation as a common postreceptor pathway for GF-induced tumor infiltration and further identify PLC-gamma1 as a possible target for anti-invasive therapy for GBMs."
06/01/1996 - "However, at 37 weeks post-injection, dietary fiber significantly altered DAG (P < 0.02), and PLC-gamma1 expression (P < 0.05) in the absence of an effect on tumor incidence. "
03/01/2010 - "These studies position PLCgamma2 as a critical regulator of the cellular and molecular mechanisms occurring in bone and immune cells during autoimmune inflammation."
04/01/2005 - "Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry."
09/01/2008 - "This study identifies a Vav/PLCgamma2-dependent signaling pathway as a possible therapeutic target for the treatment of inflammation and bone disruption in arthritis."
01/01/2010 - "Utilizing a T cell-dependent model of arthritis, we find that PLCgamma2-/- mice are protected from local inflammation and bone erosion. "
09/01/2008 - "Vav(null) and PLCgamma2(-/-) mice were protected from inflammation and bone erosion in the K/BxN serum-transfer model of arthritis. "
01/01/2010 - "This study demonstrates a critical role for PLCgamma2 in eliciting inflammatory responses by regulating actin dynamics in DCs and positions the PLCgamma2 pathway as a common orchestrator of bone and immune cell functions during arthritis."
03/01/2010 - "Indeed PLCgamma2(-/-) mice are protected from K/BxN serum transfer arthritis, which is known to require neutrophil activation. "
01/01/2010 - "Phospholipase C gamma 2 is critical for development of a murine model of inflammatory arthritis by affecting actin dynamics in dendritic cells."
03/16/2009 - "PLCgamma2 deficiency completely protected mice from clinical signs and histological features of arthritis as well as from arthritis-induced loss of articular function. "
09/01/2008 - "Arthritis was induced in wild-type (WT), Vav(null), and PLCgamma2(-/-) mice using the K/BxN serum-transfer model. "
05/01/2008 - "Phospholipase C gamma 1 regulates the Rap GEF1-Rap1 signalling axis in the control of human prostate carcinoma cell adhesion."
01/01/1994 - "By radioimmunoassay and Western blotting, PLC-gamma 1 showed three-fold to fourfold more expression in carcinomas than that in normal tissues. "
01/01/2012 - "Notably, PLC-gamma is up-regulated in colorectal cancer tissue and breast carcinoma. "
04/15/1994 - "Likewise, activity of PLC-gamma 1 was considerably higher in adenomas and carcinomas than in normal mucosa. "
04/15/1994 - "The level of PLC-gamma 1 expression increased from normal mucosa to adenoma, and finally to carcinoma progressively. "
|1.||Phospholipase C gamma
|5.||Epidermal Growth Factor Receptor (EGF Receptor)
|6.||Type C Phospholipases
|7.||Epidermal Growth Factor (EGF)
|8.||Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
|10.||Fc Receptors (Fc Receptor)