Munc18 Proteins

A family of proteins involved in intracellular membrane trafficking. They interact with SYNTAXINS and play important roles in vesicular docking and fusion during EXOCYTOSIS. Their name derives from the fact that they are related to Unc-18 protein, C elegans.

Also Known As:

Munc-18 Proteins; Munc-18b Protein; Munc18 Syntaxin Binding Proteins; Munc18-1 Protein; Munc18-2 Protein; Munc18-3 Protein; Munc18a Protein; Munc18b Protein; Munc18c Protein; Sec1-Munc18 Protein Family; Syntaxin Binding Protein Munc18; Munc 18 Proteins; Sec1 Munc18 Protein Family

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Vesicular Transport Proteins: 1
      - Munc18 Proteins: 3
        human STXBP1 protein
        human STXBP2 protein
        mouse Munc18c(L) protein
        mouse Stxbp1 protein
        mouse Stxbp2 protein
        mouse Stxbp3 protein
        rat Scfd1 protein
        rat Stxbp1 protein
        rat Stxbp2 protein
        rat Stxbp3 protein
        S cerevisiae SEC1 protein
        S cerevisiae SLY1 protein
        Xenopus Xunc18 protein
        zebrafish Scfd1 protein

Experts

1.	Adachi, Roberto: 1 article (11/2018)
2.	Burns, Alan R: 1 article (11/2018)
3.	Chavez, Miguel A: 1 article (11/2018)
4.	Costa, Renan M: 1 article (11/2018)
5.	Davalos, Alfredo J: 1 article (11/2018)
6.	Dickey, Burton F: 1 article (11/2018)
7.	Dominguez, Andrea: 1 article (11/2018)
8.	Elizondo, Ramon: 1 article (11/2018)
9.	Gutierrez, Berenice A: 1 article (11/2018)
10.	Heidelberger, Ruth: 1 article (11/2018)

Related Diseases

1.	Anaphylaxis (Anaphylactic Shock) 11/01/2018 - "Exocytosis in many cells requires the participation of Munc18 proteins (also known as syntaxin-binding proteins), and we found that mature MCs express all three mammalian isoforms: Munc18-1, -2, and -3. To study their functions in MC effector responses and test the role of MC degranulation in anaphylaxis, we used conditional knockout (cKO) mice in which each Munc18 protein was deleted exclusively in MCs. "
2.	Insulin Resistance 06/01/2003 - "To confirm the relevance of fatty acid metabolism and insulin resistance to the expression of Munc18c in vivo, a 2-fold increase in Munc18c protein was demonstrated in mice fed a high-fat diet for 4 weeks. " 03/01/2005 - "Taken together, these data suggest that the reduction of Munc18c protein in the Munc18c(-/+) mice results in impaired insulin sensitivity with a latent increased susceptibility for developing severe glucose intolerance in response to environmental perturbations such as intake of a high-calorie diet rich in fat and carbohydrate."
3.	Glucose Intolerance 03/01/2005 - "Taken together, these data suggest that the reduction of Munc18c protein in the Munc18c(-/+) mice results in impaired insulin sensitivity with a latent increased susceptibility for developing severe glucose intolerance in response to environmental perturbations such as intake of a high-calorie diet rich in fat and carbohydrate."

Related Drugs and Biologics

1.	Qa-SNARE Proteins (Syntaxin)
2.	Protein Isoforms (Isoforms)
3.	Proteins (Proteins, Gene)
4.	Carrier Proteins (Binding Protein)
5.	Fatty Acids (Saturated Fatty Acids)
6.	Carbohydrates