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Dopamine and cAMP-Regulated Phosphoprotein 32

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A phosphoprotein that was initially identified as a major target of DOPAMINE activated ADENYLYL CYCLASE in the CORPUS STRIATUM. It regulates the activities of PROTEIN PHOSPHATASE-1 and PROTEIN KINASE A, and it is a key mediator of the biochemical, electrophysiological, transcriptional, and behavioral effects of DOPAMINE.

Also Known As:

DARPP-32 Protein; Dopamine and Adenosine 3',5'-Monophosphate-Regulated Phosphoprotein; Dopamine and cAMP-Regulated Phosphoprotein; Dopamine- and Cyclic AMP-Regulated Phosphoprotein Mr 32,000; DARPP 32 Protein; Dopamine and Adenosine 3',5' Monophosphate Regulated Phosphoprotein; Dopamine and Cyclic AMP Regulated Phosphoprotein Mr 32,000; Dopamine and cAMP Regulated Phosphoprotein; Dopamine and cAMP Regulated Phosphoprotein 32

Networked: 15 relevant articles (0 outcomes, 2 trials/studies) for this Bio-Agent, Comments

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 58375
  - Phosphoproteins: 206
    - Dopamine and cAMP-Regulated Phosphoprotein 32: 15
  - Nerve Tissue Proteins: 2
    - Dopamine and cAMP-Regulated Phosphoprotein 32: 15

Experts

1.	Wang, Jin: 2 articles (01/2008 - 08/2004)
2.	Hong, Liu: 2 articles (01/2008 - 08/2004)
3.	Vogel, Wolfgang F: 1 article (10/2009)
4.	Tengholm, Anders: 1 article (10/2009)
5.	Nairn, Angus C: 1 article (10/2009)
6.	Howlin, Jillian: 1 article (10/2009)
7.	Hansen, Christian: 1 article (10/2009)
8.	Greengard, Paul: 1 article (10/2009)
9.	Dyachok, Oleg: 1 article (10/2009)
10.	Andersson, Tommy: 1 article (10/2009)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 10/01/2006 - "Hence, our results suggest that the reduced DARPP-32 protein in patients with schizophrenia is unlikely caused by mutations in the DARPP-32 gene itself and the DARPP-32 gene is also unlikely a major susceptibility gene for schizophrenia. " 03/01/2008 - "Several lines of evidence, including genome-wide linkage scans and postmortem brain studies of patients with schizophrenia or bipolar disorder, have suggested that DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa), a key regulatory molecule in the dopaminergic signaling pathway, is involved in these disorders. " 09/14/2009 - "Recent findings have highlighted the importance of DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa), a key regulatory molecule in the dopaminergic signalling pathway for dopamine related phenotypes like antisocial-behavior, drug addiction and schizophrenia. " Order ALL the reference details at left...
2.	Dyskinesias (Dyskinesia) 05/01/2006 - "Objective To study the changes of prodynorphin (PDyn) gene expression and dopamine and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) phosphorylation in rats with levodopa-induced dyskinesia (LID), and to explore the mechanism of over-activation in direct pathway mediated by dopamine D(1) receptor. " Order ALL the reference details at left...
3.	Bipolar Disorder (Mania) 03/01/2008 - "Several lines of evidence, including genome-wide linkage scans and postmortem brain studies of patients with schizophrenia or bipolar disorder, have suggested that DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa), a key regulatory molecule in the dopaminergic signaling pathway, is involved in these disorders. " Order ALL the reference details at left...
4.	Substance-Related Disorders (Drug Abuse) 01/01/2009 - "The 32-kDa dopamine- and adenosine 3',5'-monophosphate-regulated phosphoprotein (DARPP-32) is recognized to be critical to the pathogenesis of drug addiction. " 09/14/2009 - "Recent findings have highlighted the importance of DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa), a key regulatory molecule in the dopaminergic signalling pathway for dopamine related phenotypes like antisocial-behavior, drug addiction and schizophrenia. " Order ALL the reference details at left...
5.	Neoplasms (Cancer) 07/05/2004 - "This is the first report to correlate DARPP-32 immunoreactivity (dopamine and cAMP-regulated phosphoprotein, M(r) 32 000) to clinicopathological status in human cancer. " 08/01/2004 - "There was no significant association between DARPP-32 protein expression and degree of tumor differentiation, local invasion and distant metastasis. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Dopamine (Intropin)
2.	preproenkephalin
3.	Levodopa (L Dopa)
4.	Glial Fibrillary Acidic Protein
5.	Facilitative Glucose Transport Proteins (Glucose Transporter)
6.	Lamin Type A (Lamin A)
7.	Ubiquitin
8.	Streptavidin
9.	Tachykinins
10.	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)

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