Centromere Protein B

A DNA-binding protein that interacts with a 17-base pair sequence known as the CENP-B box motif. The protein is localized constitutively to the CENTROMERE and plays an important role in its maintenance.

Also Known As:

Networked: 14 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Adler, Brittany: 1 article (11/2022)
2.	Hummers, Laura K: 1 article (11/2022)
3.	McMahan, Zsuzsanna H: 1 article (11/2022)
4.	Pasricha, P Jay: 1 article (11/2022)
5.	Jin, Haiguo: 1 article (02/2022)
6.	Liu, Hairui: 1 article (02/2022)
7.	Sun, Tao: 1 article (02/2022)
8.	Tian, Weicheng: 1 article (02/2022)
9.	Zhang, Yingying: 1 article (02/2022)
10.	Borghi, Maria Orietta: 1 article (12/2020)

Related Diseases

1.	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 07/01/1995 - "The purpose of the present study is to evaluate the centromeric pattern on human laryngeal tumour (HEp-2) cells by indirect immunofluorescent (IIF) test and to compare their reactivities with a newly developed recombinant centromere protein B enzyme linked immunosorbent assay (CENP-B ELISA) test using sera of antinuclear antibody (ANA)-reactive primary biliary cirrhosis (PBC) patients. "
2.	Autoimmune Diseases (Autoimmune Disease) 10/01/1992 - "Centromere protein B (CENP-B), which is an alphoid DNA binding protein, is the target antigen in autoimmune disease patients (often with scleroderma). " 02/01/1992 - "The purified protein was identified as the centromere protein B (CENP-B) by its mobility on SDS-PAGE (80 kD), and reactivities to a monoclonal antibody raised to CENP-B (bacterial fusion protein) and to anticentromere sera from patients with autoimmune diseases. " 01/01/1992 - "Centromere protein B (CENP-B), which is an alphoid DNA binding protein, is the target antigen in autoimmune disease patients (often those with scleroderma). "
3.	Gastroparesis 11/02/2022 - "Higher anti-centromere protein B (CENP-B) titres correlated with slower gastric emptying (ρ = -0.26, P = 0.03), but no specific clinical features of SSc were associated with gastroparesis. "
4.	CREST Syndrome (Syndrome, CREST) 01/01/2020 - "Extensive immunological workup unexpectedly revealed the presence of anti-centromere protein B (anti-CENP B) antibodies which are strongly associated with CREST syndrome. "
5.	Polymyositis 01/01/2018 - "Sera from Black participants (61 patients with SLE and 100 controls) aged 1-81 years were analysed for reactivity against the antigens: uridine 1-ribonuclear protein, Smith uridine-1-5 ribonuclear protein antigen, soluble substance-A, recombinant Ro-52, soluble substance-B, Scl-70, cytoplasmic histidyl-tRNA synthetase antigen, proliferating cell nuclear antigen (PCNA), nucleosomes, ribonuclear P-protein, antimitochondrial antibody M2 (AMA-M2), histones, double-stranded DNA (dsDNA), centromere protein B and polymyositis-sclerosis overlap antigen. "

Related Drugs and Biologics

1.	Immunosorbents
2.	Enzymes
3.	Antinuclear Antibodies
4.	Proteins (Proteins, Gene)
5.	DNA (Deoxyribonucleic Acid)
6.	Antigens
7.	Antibodies
8.	Messenger RNA (mRNA)
9.	Nucleosomes (Nucleosome)
10.	Histones (Histone)