Sex-Determining Region Y Protein (Testis-Determining Factor)

A transcription factor that plays an essential role in the development of the TESTES. It is encoded by a gene on the Y chromosome and contains a specific HMG-BOX DOMAIN that is found within members of the SOX family of transcription factors.

Also Known As:

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cabrero, Pablo: 1 article (10/2019)
2.	Davies, Shireen A: 1 article (10/2019)
3.	Dow, Julian A T: 1 article (10/2019)
4.	Ghimire, Saurav: 1 article (10/2019)
5.	Romero, Michael F: 1 article (10/2019)
6.	Terhzaz, Selim: 1 article (10/2019)
7.	Ravel, C: 1 article (06/2009)
8.	Siffroi, J-P: 1 article (06/2009)
9.	Inoue, Jun-Ichiro: 1 article (09/2003)
10.	Matsuzawa-Watanabe, Yumiko: 1 article (09/2003)

Related Diseases

1.	Sex Chromosome Aberrations (Sex Chromosome Abnormality) 09/01/1989 - "Studies on individuals with sex chromosome abnormalities indicate that a testis determining factor (TDF) is located on the short arm of the Y chromosome. "
2.	Gonadal Dysgenesis (Gonadal Agenesis) 06/01/2009 - "In women with isolated gonadal dysgenesis but otherwise normal stature, the testis determining factor or SRY gene may have been removed from the Y chromosome or may be mutated. " 01/01/1997 - "Testis-determining factor and gonadal dysgenesis." 12/01/1992 - "A familial mutation in SRY, the gene coding for the testis-determining factor TDF, was identified in an XY female with gonadal dysgenesis, her father, her two brothers and her uncle. "
3.	Campomelic Dysplasia 03/01/1998 - "In humans, mutations in the gene for SOX9, a transcription factor with a DNA-binding domain similar to that of the mammalian testis-determining factor SRY, cause campomelic dysplasia, a severe dwarfism syndrome which affects all cartilage-derived structures. "
4.	Nephrolithiasis 10/01/2019 - "Here, we demonstrated function of the sex-determining region Y protein-interacting protein-1 (Sip1) gene, an ortholog of human Na+/H+ exchanger regulatory factor (NHERF1), in Drosophila Malpighian tubules and its impact on nephrolithiasis. "
5.	Disorders of Sex Development (Intersexuality) 08/01/1992 - "These findings, together with ambiguous genitalia in the girls, indicate that the marker chromosomes include the testis-determining factor gene."

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