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Fragile X Mental Retardation Protein

A RNA-binding protein that is found predominately in the CYTOPLASM. It helps regulate GENETIC TRANSLATION in NEURONS and is absent or under-expressed in FRAGILE X SYNDROME.
Also Known As:
FMRP Protein; Fragile X Mental Retardation-1 Protein; Fragile X Mental Retardation 1 Protein
Networked: 328 relevant articles (1 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Bassell, Gary J: 16 articles (11/2015 - 03/2004)
2. Warren, Stephen T: 16 articles (03/2015 - 01/2002)
3. Jin, Peng: 15 articles (10/2014 - 03/2003)
4. Greenough, William T: 13 articles (08/2010 - 01/2002)
5. Bagni, Claudia: 11 articles (07/2015 - 02/2003)
6. Oostra, Ben A: 11 articles (11/2013 - 08/2002)
7. Willemsen, Rob: 10 articles (03/2014 - 12/2002)
8. Khandjian, Edouard W: 10 articles (10/2013 - 11/2002)
9. Weiler, Ivan Jeanne: 10 articles (08/2010 - 05/2002)
10. Bardoni, Barbara: 8 articles (10/2014 - 09/2003)

Related Diseases

1. Obesity
2. Fragile X Syndrome (Martin Bell Syndrome)
3. Schizophrenia (Dementia Praecox)
12/30/2013 - "Decreased fragile X mental retardation protein (FMRP) is associated with lower IQ and earlier illness onset in patients with schizophrenia."
09/01/2015 - "Cytoplasmic FMR1-interacting protein 1 (CYFIP1) is of particular interest because of its interaction with Fragile X mental retardation protein (FMRP), its upregulation in transformed lymphoblastoid cell lines from patients with duplications at 15q11-13 and ASD and the presence of smaller overlapping deletions of CYFIP1 in patients with schizophrenia and intellectual disability. "
10/01/2013 - "Recent studies demonstrated a reduced expression of Fragile X Mental Retardation Protein (FMRP), an RNA binding protein and translation regulator, in the brain and peripheral lymphocytes of patients with schizophrenia. "
12/30/2013 - "The purpose of this study was to investigate Fragile X Syndrome (FXS)-related mechanisms in schizophrenia, including CGG triplet expansion, FMR1 mRNA, and fragile X mental retardation protein (FMRP) levels in lymphocytes. "
01/01/2015 - "In these studies, schizophrenia patients were found to have enriched de novo mutations in genes belonging to the postsynaptic density at glutamatergic synapses, particularly components of the N-methyl-D-aspartate receptor signaling complex, including the PSD-95 complex, activity-regulated cytoskeleton-associated protein interactors, the fragile X mental retardation protein complex, voltage-gated calcium channels, and genes implicated in actin cytoskeletal dynamics. "
4. Autistic Disorder (Autism)
5. Mental Retardation (Idiocy)

Related Drugs and Biologics

1. Brain-Derived Neurotrophic Factor (BDNF)
2. RNA-Binding Proteins (RNA-Binding Protein)
3. Messenger RNA (mRNA)
4. RNA (Ribonucleic Acid)
5. Proteins (Proteins, Gene)
6. metabotropic glutamate receptor 5
7. N-Methylaspartate (NMDA)
8. Heterogeneous-Nuclear Ribonucleoproteins (Informatin)
9. rac1 GTP-Binding Protein
10. Protein Tyrosine Phosphatases