|1.||Bassell, Gary J: 16 articles (11/2015 - 03/2004)|
|2.||Warren, Stephen T: 16 articles (03/2015 - 01/2002)|
|3.||Jin, Peng: 15 articles (10/2014 - 03/2003)|
|4.||Greenough, William T: 13 articles (08/2010 - 01/2002)|
|5.||Bagni, Claudia: 11 articles (07/2015 - 02/2003)|
|6.||Oostra, Ben A: 11 articles (11/2013 - 08/2002)|
|7.||Willemsen, Rob: 10 articles (03/2014 - 12/2002)|
|8.||Khandjian, Edouard W: 10 articles (10/2013 - 11/2002)|
|9.||Weiler, Ivan Jeanne: 10 articles (08/2010 - 05/2002)|
|10.||Bardoni, Barbara: 8 articles (10/2014 - 09/2003)|
|2.||Fragile X Syndrome (Martin Bell Syndrome)
07/01/2015 - "In this study, a specific and sensitive fluorescence resonance energy transfer-based assay for fragile X mental retardation protein detection was developed and optimized for high-throughput screening (HTS) of compound libraries using fragile X syndrome (FXS) patient-derived neural stem cells. "
02/13/2007 - "Recent neuroanatomical studies indicate an apparent immature appearance of neurons in fragile X syndrome patients and fragile X mental retardation protein (FMRP)-knockout mice, an animal model of this condition. "
02/20/2003 - "Recent studies provide new insight into the mechanistic function of Fragile X Mental Retardation Protein (FMRP), paving the way to understanding the biological basis of Fragile X Syndrome. "
11/01/2015 - "Fragile X syndrome (FXS) is caused by transcriptional silencing of the fmr1 gene resulting in the loss of fragile X mental retardation protein (FMRP) expression. "
07/01/2015 - ": Fragile X syndrome (FXS), the most common form of inherited cognitive disability, is caused by a deficiency of the fragile X mental retardation protein (FMRP). "
|3.||Schizophrenia (Dementia Praecox)
12/30/2013 - "Decreased fragile X mental retardation protein (FMRP) is associated with lower IQ and earlier illness onset in patients with schizophrenia."
09/01/2015 - "Cytoplasmic FMR1-interacting protein 1 (CYFIP1) is of particular interest because of its interaction with Fragile X mental retardation protein (FMRP), its upregulation in transformed lymphoblastoid cell lines from patients with duplications at 15q11-13 and ASD and the presence of smaller overlapping deletions of CYFIP1 in patients with schizophrenia and intellectual disability. "
10/01/2013 - "Recent studies demonstrated a reduced expression of Fragile X Mental Retardation Protein (FMRP), an RNA binding protein and translation regulator, in the brain and peripheral lymphocytes of patients with schizophrenia. "
12/30/2013 - "The purpose of this study was to investigate Fragile X Syndrome (FXS)-related mechanisms in schizophrenia, including CGG triplet expansion, FMR1 mRNA, and fragile X mental retardation protein (FMRP) levels in lymphocytes. "
01/01/2015 - "In these studies, schizophrenia patients were found to have enriched de novo mutations in genes belonging to the postsynaptic density at glutamatergic synapses, particularly components of the N-methyl-D-aspartate receptor signaling complex, including the PSD-95 complex, activity-regulated cytoskeleton-associated protein interactors, the fragile X mental retardation protein complex, voltage-gated calcium channels, and genes implicated in actin cytoskeletal dynamics. "
|4.||Autistic Disorder (Autism)
01/01/2015 - "Many studies have demonstrated a robust statistical overlap between genes whose transcripts are reported as Fragile X Mental Retardation Protein (Fmrp)-binding targets and genes implicated in various psychiatric disorders, including autism. "
12/01/2014 - "We identify FAM120C as a novel X-linked candidate gene for autism for two reasons: first, a larger deletion encompassing FAM120C segregates with autism in a previously reported family and second, there is recent evidence that FAM120C interacts with CYFIP1, part of the FMRP (Fragile X Mental Retardation Protein) network. "
10/01/2014 - "Left fusiform habituation in female participants was directly correlated with higher, more typical levels of the fragile X mental retardation protein and inversely correlated with autism symptoms. "
02/13/2014 - "Similar to reports in autism, targets of the fragile X mental retardation protein (FMRP, product of FMR1) are enriched for case mutations. "
12/15/2012 - "Surprisingly, during development, DhMRs are highly enriched in genes encoding mRNAs that can be regulated by fragile X mental retardation protein (FMRP), some of which are disrupted in autism, as well as in many known autism genes. "
|5.||Mental Retardation (Idiocy)
12/01/2015 - "The cause for this X-linked disorder is the silencing of the fragile X mental retardation 1 (fmr1) gene and the absence of the fragile X mental retardation protein (Fmrp). "
09/01/2015 - "Altered expression of GABAA receptor subunits has been documented in fragile X mental retardation 1 (FMR1) knockout mice, suggesting that loss of its protein product, fragile X mental retardation protein (FMRP), impacts GABAA subunit expression. "
01/01/2015 - "The etiology of FXS is linked to the expansion of the CGG trinucleotide repeats, r(CGG), suppressing the fragile X mental retardation 1 (FMR1) gene on the X chromosome, resulting in a loss of fragile X mental retardation protein (FMRP) expression, which is required for regulating normal neuronal connectivity and plasticity. "
01/01/2015 - "By applying this method, high-quality crystals of the flexible N-terminus of human fragile X mental retardation protein are obtained, whose absence causes the most common inherited mental retardation. "
01/01/2015 - "Caused by a silenced fragile X mental retardation 1 gene and the subsequent deficiency in fragile X mental retardation protein, patients with FXS experience a range of physical, behavioral, and intellectual debilitations. "
|1.||Brain-Derived Neurotrophic Factor (BDNF)
|2.||RNA-Binding Proteins (RNA-Binding Protein)
|3.||Messenger RNA (mRNA)
|4.||RNA (Ribonucleic Acid)
|5.||Proteins (Proteins, Gene)
|6.||metabotropic glutamate receptor 5
|8.||Heterogeneous-Nuclear Ribonucleoproteins (Informatin)
|9.||rac1 GTP-Binding Protein
|10.||Protein Tyrosine Phosphatases