Forkhead Transcription Factors (Forkhead Box Proteins)

A subclass of winged helix DNA-binding proteins that share homology with their founding member fork head protein, Drosophila.

Also Known As:

Forkhead Box Proteins; Forkhead Box Transcription Factors; Forkhead Proteins; Fox Transcription Factors; Box Protein, Forkhead; Box Proteins, Forkhead; Factor, Forkhead Transcription; Protein, Forkhead; Protein, Forkhead Box; Proteins, Forkhead Box; Transcription Factor, Forkhead; Transcription Factors, Forkhead; Transcription Factors, Fox; Forkhead Box Protein; Forkhead Box Transcription Factor; Forkhead Protein; Forkhead Transcription Factor

Networked: 1105 relevant articles (12 outcomes, 122 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Winged-Helix Transcription Factors: 6
      - Forkhead Transcription Factors: 1105
        Forkhead Box Protein M1: 137
        Forkhead Box Protein O1: 115
        Forkhead Box Protein O3: 29
        Forkhead Box Protein L2: 14
        Hepatocyte Nuclear Factor 3-alpha: 6
        Hepatocyte Nuclear Factor 3-beta: 5
        mesenchyme fork head 1 protein: 3
        interleukin binding factor: 1
        mouse Foxp3 protein: 1
        Acremonium chrysogenum FKH1 protein
        Arabidopsis AT4G16670 protein
        Branchiostoma floridae HNF-3 protein
        C elegans daf-16 protein
        C elegans DAF-31 protein
        C elegans fkh-10 protein
        C elegans fkh-6 protein
        C elegans fkh-8 protein
        C elegans fkh-9 protein
        C elegans FOXO3a protein
        C elegans let-381 protein
        Drosophila bin protein
        Drosophila CHES-1-like protein
        Drosophila fd3F protein
        Drosophila fd59a protein
        Drosophila fkh protein
        Drosophila FoxK protein
        Drosophila FoxL1 protein
        Drosophila FOXO protein
        Drosophila FoxP protein
        Hepatocyte Nuclear Factor 3-gamma
        human FOXB1 protein
        human FOXB2 protein
        human FOXC1 protein
        human FOXD1 protein
        human FOXD2 protein
        human FOXD3 protein
        human FOXD4 protein
        human FOXD4L1 protein
        human FOXE1 protein
        human FOXE3 protein
        human FOXF1 protein
        human FOXF2 protein
        human FOXG1 protein
        human FOXH1 protein
        human FOXI1 protein
        human Foxi3 protein
        human FOXJ1 protein
        human FOXJ2 protein
        human FoxJ3 protein
        human FOXK1 protein
        human FOXL1 protein
        human FOXN2 protein
        human FOXN3 protein
        human FOXN4 protein
        human FOXO4 protein
        human FOXO6 protein
        human FOXP1 protein
        human FOXP2 protein
        human FOXP3 protein
        human FOXP4 protein
        human FOXQ1 protein
        human FOXR1 protein
        human FOXR2 protein
        human FOXS1 protein
        mouse 1700012B09Rik protein
        mouse Foxb1 protein
        mouse Foxb2 protein
        mouse Foxc1 protein
        mouse Foxd1 protein
        mouse Foxd2 protein
        mouse Foxd3 protein
        mouse Foxe1 protein
        mouse Foxe3 protein
        mouse Foxf1 protein
        mouse Foxf2 protein
        mouse Foxg1 protein
        mouse Foxh1 protein
        mouse Foxi1 protein
        mouse Foxi3 protein
        mouse FOXJ1 protein
        mouse Foxj2 protein
        mouse FoxJ3 protein
        mouse Foxk1 protein
        mouse FoxK2 protein
        mouse Foxl1 protein
        mouse Foxn2 protein
        mouse Foxn3 protein
        mouse Foxn4 protein
        mouse Foxn5 protein
        mouse FoxO4 protein
        mouse Foxo6 protein
        mouse Foxp1 protein
        mouse Foxp2 protein
        mouse Foxp4 protein
        mouse Foxq1 protein
        mouse Foxr2 protein
        mouse Foxs1 protein
        pig FOXO1A protein
        rat Foxc1 protein
        rat Foxd1 protein
  - DNA-Binding Proteins: 2009
    - Winged-Helix Transcription Factors: 6
      - Forkhead Transcription Factors: 1105
        Forkhead Box Protein M1: 137
        Forkhead Box Protein O1: 115
        Forkhead Box Protein O3: 29
        Forkhead Box Protein L2: 14
        Hepatocyte Nuclear Factor 3-alpha: 6
        Hepatocyte Nuclear Factor 3-beta: 5
        mesenchyme fork head 1 protein: 3
        interleukin binding factor: 1
        mouse Foxp3 protein: 1
        Acremonium chrysogenum FKH1 protein
        Arabidopsis AT4G16670 protein
        Branchiostoma floridae HNF-3 protein
        C elegans daf-16 protein
        C elegans DAF-31 protein
        C elegans fkh-10 protein
        C elegans fkh-6 protein
        C elegans fkh-8 protein
        C elegans fkh-9 protein
        C elegans FOXO3a protein
        C elegans let-381 protein
        Drosophila bin protein
        Drosophila CHES-1-like protein
        Drosophila fd3F protein
        Drosophila fd59a protein
        Drosophila fkh protein
        Drosophila FoxK protein
        Drosophila FoxL1 protein
        Drosophila FOXO protein
        Drosophila FoxP protein
        Hepatocyte Nuclear Factor 3-gamma
        human FOXB1 protein
        human FOXB2 protein
        human FOXC1 protein
        human FOXD1 protein
        human FOXD2 protein
        human FOXD3 protein
        human FOXD4 protein
        human FOXD4L1 protein
        human FOXE1 protein
        human FOXE3 protein
        human FOXF1 protein
        human FOXF2 protein
        human FOXG1 protein
        human FOXH1 protein
        human FOXI1 protein
        human Foxi3 protein
        human FOXJ1 protein
        human FOXJ2 protein
        human FoxJ3 protein
        human FOXK1 protein
        human FOXL1 protein
        human FOXN2 protein
        human FOXN3 protein
        human FOXN4 protein
        human FOXO4 protein
        human FOXO6 protein
        human FOXP1 protein
        human FOXP2 protein
        human FOXP3 protein
        human FOXP4 protein
        human FOXQ1 protein
        human FOXR1 protein
        human FOXR2 protein
        human FOXS1 protein
        mouse 1700012B09Rik protein
        mouse Foxb1 protein
        mouse Foxb2 protein
        mouse Foxc1 protein
        mouse Foxd1 protein
        mouse Foxd2 protein
        mouse Foxd3 protein
        mouse Foxe1 protein
        mouse Foxe3 protein
        mouse Foxf1 protein
        mouse Foxf2 protein
        mouse Foxg1 protein
        mouse Foxh1 protein
        mouse Foxi1 protein
        mouse Foxi3 protein
        mouse FOXJ1 protein
        mouse Foxj2 protein
        mouse FoxJ3 protein
        mouse Foxk1 protein
        mouse FoxK2 protein
        mouse Foxl1 protein
        mouse Foxn2 protein
        mouse Foxn3 protein
        mouse Foxn4 protein
        mouse Foxn5 protein
        mouse FoxO4 protein
        mouse Foxo6 protein
        mouse Foxp1 protein
        mouse Foxp2 protein
        mouse Foxp4 protein
        mouse Foxq1 protein
        mouse Foxr2 protein
        mouse Foxs1 protein
        pig FOXO1A protein
        rat Foxc1 protein
        rat Foxd1 protein

Experts

1.	Maiese, Kenneth: 19 articles (03/2021 - 09/2004)
2.	Chong, Zhao Zhong: 11 articles (01/2013 - 09/2004)
3.	Banham, Alison H: 10 articles (01/2015 - 05/2004)
4.	Oda, Yoshinao: 8 articles (05/2021 - 09/2015)
5.	Lam, Eric W-F: 8 articles (01/2019 - 09/2006)
6.	Xie, Keping: 8 articles (01/2019 - 04/2006)
7.	Shang, Yan Chen: 8 articles (01/2013 - 07/2008)
8.	Inoue, Satoshi: 7 articles (12/2016 - 09/2008)
9.	Hou, Jinling: 7 articles (03/2010 - 07/2008)
10.	Liu, Jian: 6 articles (09/2021 - 11/2012)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2009 - "Expression of the forkhead box transcription factor FOXP1 is associated with oestrogen receptor alpha, oestrogen receptor beta and improved survival in familial breast cancers." 09/28/2022 - "Although studies have suggested that several FOX transcription factors have a significant impact on cancer, the functions of most of the FOX genes in cancer remain elusive. " 03/01/2020 - "Many studies have focused on correlations between forkhead box protein C2 (FOXC2) and various tumors but discrepant results have been reported. " 01/01/2020 - "Background: Emerging studies have demonstrated that the Forkhead transcription factor FOXO3a is closely correlated with the progression of multiple tumors. " 01/01/2017 - "Recent studies have provided clear evidence that some types of human cancer cells expressed Forkhead Box Protein 3 (FOXP3). "
2.	Insulin Resistance 11/01/2013 - "Changes in the levels of forkhead transcription factor 1 and SIRT4 could suggest increased fat utilization and improved insulin sensitivity. " 01/01/2022 - "The hepatic transcription factor forkhead box O1 (FOXO1) is a critical regulator of hepatic and systemic insulin sensitivity. " 03/17/2006 - "Forkhead transcription factor FOXC2 is an important regulator of insulin resistance. " 03/01/2006 - "Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance." 12/01/2003 - "The FOXO family of forkhead transcription factors stimulates the transcription of target genes involved in many fundamental cell processes, including cell survival, cell cycle progression, DNA repair, and insulin sensitivity. "
3.	Hypoxia (Hypoxemia) 01/01/2020 - "Here, we define a role for the transcription factor Forkhead Box-O (FOXO) as a mediator of hypoxia tolerance in Drosophila We find that upon hypoxia exposure, FOXO transcriptional activity is rapidly induced in both larvae and adults. " 12/02/2016 - "Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL)." 04/15/2011 - "Increased oxidative stress upregulated forkhead transcription factor (FoxO3a) and hypoxia-inducible factor-(HIF)1α in the spleen and kidney of Se-deficient murine as well as in the proerythroblast G1E cells cultured in Se-deficient media. " 05/01/2010 - "We tested involvement of biochemical and biophysical parameters and potential transcription factors Forkhead box (FOX) and hypoxia-inducible factor (HIF-1alpha). " 02/01/2010 - "These effects are mediated by a switch from hypoxia-inducible factor 1alpha (HIF1alpha) to forkhead transcription factor O (FoxO)-dependent transcription. "
4.	Breast Neoplasms (Breast Cancer) 06/01/2016 - "The aim of the present study was to investigate the associations between the expression of forkhead box protein A1 (FOXA1) and differential clinicopathological characteristics in breast cancer using a meta-analysis method. " 04/01/2012 - "In this study, we evaluated whether forkhead-box protein A1 (FOXA1) expression was a prognostic and predictive marker for HR-positive breast cancer. " 04/15/2011 - "In this study, we defined a critical functional role for the Forkhead transcription factor FOXQ1 in regulating EMT in breast cancer cells. " 07/01/2022 - "Forkhead Box Protein 3 (FOXP3), as an essential marker of regulatory T cell (Treg) development, is reportedly overexpressed in invasive breast carcinoma (BRCA) and could be a potential prognostic factor for BRCA. " 05/01/2020 - "Female mice heterozygous for a genetic mutation in transcription factor forkhead box p3 (Foxp3) spontaneously develop mammary cancers; however, the underlying mechanism is not well understood. "
5.	Inflammation (Inflammations) 06/01/2013 - "Recent studies have shown that the transcription factor Forkhead box O3 (FOXO3) regulates inflammation in nongestational tissues such as adipocytes and hepatocytes. " 01/01/2009 - "The aim of this study was to investigate whether the changes in the forkhead transcription factor 3 (Foxp3) gene expression may aggravate nasal mucosal inflammation in allergic mice, and whether or not these features result from the loss of Tregs. " 12/09/2022 - "Forkhead transcription factor O1 (FOXO1) methylation is associated with inflammation. " 01/01/2020 - "Further, the forkhead box transcription factor 3 (Foxp3) was analyzed to hint the injury mechanism of inflammation. " 01/01/2019 - "Forkhead box protein A2 (Foxa2) plays a critical role in Th2 inflammation and is associated with pulmonary defenses. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Cytokines
3.	Intercellular Signaling Peptides and Proteins (Growth Factors)
4.	Erythropoietin
5.	Transcription Factors (Transcription Factor)
6.	Phosphotransferases (Kinase)
7.	Sirtuin 1
8.	Insulin (Novolin)
9.	Proto-Oncogene Proteins c-akt (Protein Kinase B)
10.	Insulin Receptor

Related Therapies and Procedures

1.	Immunotherapy
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)
4.	Neoadjuvant Therapy
5.	Electroacupuncture