Fanconi Anemia Complementation Group Proteins

A diverse group of proteins whose genetic MUTATIONS have been associated with the chromosomal instability syndrome FANCONI ANEMIA. Many of these proteins play important roles in protecting CELLS against OXIDATIVE STRESS.

Also Known As:

Networked: 29 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Rosselli, Filippo: 3 articles (01/2022 - 09/2009)
2.	Joenje, Hans: 2 articles (11/2015 - 10/2003)
3.	Wang, Weidong: 2 articles (02/2004 - 10/2003)
4.	Yan, Zhijiang: 2 articles (02/2004 - 10/2003)
5.	Badra Fajardo, Nibal: 1 article (01/2022)
6.	Gueiderikh, Anna: 1 article (01/2022)
7.	Lygerou, Zoi: 1 article (01/2022)
8.	Maczkowiak-Chartois, Frédérique: 1 article (01/2022)
9.	Taraviras, Stavros: 1 article (01/2022)
10.	Adelman, Emmalee R: 1 article (01/2021)

Related Diseases

1.	Fanconi Anemia (Fanconi's Anemia) 01/01/2017 - "This review delineates the roles of the Fanconi anemia pathway and the molecular actions of Fanconi anemia proteins in confronting replicative, oxidative, and mitotic stress." 05/01/2013 - "Brief report: human pluripotent stem cell models of fanconi anemia deficiency reveal an important role for fanconi anemia proteins in cellular reprogramming and survival of hematopoietic progenitors." 01/01/2003 - "Because FANCC protects hematopoietic cells from apoptotic cues in ways that do not require an intact heteromeric Fanconi anemia complex, it is reasonable to expect that the other Fanconi anemia gene products will have independent cytoplasmic and nuclear functions, particularly in hematopoietic and germ cells that seem to rely so substantially on an intact portfolio of Fanconi anemia proteins." 11/01/2000 - "The fanconi anemia proteins FANCA and FANCG stabilize each other and promote the nuclear accumulation of the Fanconi anemia complex." 12/01/1997 - "Although the first Fanconi anemia gene (FAC) was cloned over 5 years ago, and a second Fanconi anemia gene (FAA) was cloned in 1996, the biochemical function of Fanconi anemia proteins largely remains a mystery. "
2.	Genomic Instability 01/01/2019 - "Holding All the Cards-How Fanconi Anemia Proteins Deal with Replication Stress and Preserve Genomic Stability." 01/01/2017 - "Maintenance of genome stability by Fanconi anemia proteins." 09/15/2009 - "These findings open new directions in understanding the mechanisms of chromosome fragility and the role of FANC proteins in preserving genome stability." 04/11/2008 - "The observations indicate that Fanconi anemia proteins act in concert with chromatin remodeling functions to maintain genome stability after DNA cross-link damage." 07/01/2016 - "This review summarizes the interplay between the ubiquitin and ubiquitin-like proteins and the FANC proteins that constitute a major pathway for the surveillance of the genomic integrity and addresses the implications of their interactions in maintaining genome stability."
3.	Neoplasms (Cancer) 09/20/2020 - "Canonical and Noncanonical Roles of Fanconi Anemia Proteins: Implications in Cancer Predisposition." 01/01/2022 - "Fanconi anemia proteins and genome fragility: unraveling replication defects for cancer therapy." 12/01/2019 - "Since aberrant expression of DNA damage-response associated Fanconi anemia proteins play a central role in the onset and therapy resistance of many cancers, we here investigated if FANCD2 depletion could sensitize pHGG to additional DNA damage. " 07/31/2009 - "The Fanconi anemia (FA) molecular network consists of 15 "FANC" proteins, of which 13 are associated with mutations in patients with this cancer-prone chromosome instability disorder. " 02/01/2009 - "Fanconi anemia proteins, DNA interstrand crosslink repair pathways, and cancer therapy."
4.	Chromosomal Instability (Chromosome Stability) 09/15/2009 - "However, it is not completely understood how the FANC proteins perform their functions and maintain chromosome stability. " 01/01/2019 - "Fanconi anemia complementation (FANC) proteins have been related to chromosomal instability and alterations in the mechanisms of p53 activation, control of cell cycle, and apoptosis. " 09/15/2009 - "Collectively, our data highlight a new role for the FANC proteins in the prevention of chromosome instability and aneuploidy. " 03/01/1999 - "The current review describes the structure and function of the Fanconi anemia genes and describes the role of the encoded Fanconi anemia proteins in a cellular pathway controlling chromosome stability." 07/31/2009 - "The Fanconi anemia (FA) molecular network consists of 15 "FANC" proteins, of which 13 are associated with mutations in patients with this cancer-prone chromosome instability disorder. "
5.	Breast Neoplasms (Breast Cancer) 02/01/2004 - "Monoubiquitination of FANCD2 is a key step in the DNA damage response pathway involving Fanconi anemia proteins and the breast cancer susceptibility gene products, BRCA1 and BRCA2. " 10/01/2003 - "Fanconi anemia proteins function in a DNA damage response pathway involving breast cancer susceptibility gene products, BRCA1 and BRCA2 (refs. " 09/04/2001 - "Furthermore, the breast cancer-associated proteins Brca1 and Brca2, the Fanconi anemia-associated FANC proteins, and cell cycle checkpoint proteins are involved in regulating the cellular response to ICLs. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Fanconi Anemia Complementation Group Proteins
3.	A-Form DNA (A-DNA)
4.	Ubiquitin
5.	Ubiquitins
6.	Proteins (Proteins, Gene)
7.	DNA Helicases

Related Therapies and Procedures

1.	Therapeutics
2.	Transjugular Intrahepatic Portasystemic Shunt