|1.||Surguchov, Andrei: 7 articles (12/2008 - 04/2002)|
|2.||Surgucheva, Irina: 6 articles (12/2008 - 04/2002)|
|3.||Trojanowski, J Q: 5 articles (09/2001 - 05/2000)|
|4.||Buchman, Vladimir L: 4 articles (01/2015 - 05/2008)|
|5.||Ye, Qing: 4 articles (06/2010 - 10/2008)|
|6.||Feng, Bo: 4 articles (06/2010 - 10/2008)|
|7.||Jiang, Yangfu: 4 articles (03/2009 - 07/2003)|
|8.||Lee, V M: 4 articles (04/2001 - 05/2000)|
|9.||Ninkina, Natalia: 3 articles (01/2015 - 05/2008)|
|10.||Marsh-Armstrong, Nicholas: 3 articles (01/2013 - 01/2008)|
12/26/2008 - "gamma-Synuclein (Syn G) is highly expressed in retinal ganglion cells and the loss of these cells in glaucoma is associated with significant reduction of the intracellular Syn G level. "
04/01/2002 - "In the optic nerve from control and glaucomatous individuals, nerve bundles are immunopositive for gamma-synuclein; however, a strong gamma-synuclein-immunopositive staining in a subset of glial cells was observed in the lamina and postlamina cribrosa regions of the optic nerve only in glaucoma patients. "
01/01/2008 - "Previous studies have described gamma-synuclein as a protein highly expressed in retinal ganglion cells (RGCs), and a loss of RGCs correlates with a downregulation of gamma-synuclein gene expression in glaucoma. "
01/09/2008 - "Taking advantage of the fact that gamma-synuclein (Sncg) mRNA is expressed specifically and highly in adult mouse RGCs, we show in the DBA/2J mouse model of glaucoma that there is not only a loss of cells expressing this gene, but also a downregulation of gene expression of Sncg and many other genes within large numbers of RGCs. "
09/01/2005 - "Since myocilin and gamma-synuclein have partially overlapping intracellular localization in cell types that are implicated in glaucoma development, their interaction may play an important role in glaucoma."
|2.||Parkinson Disease (Parkinson's Disease)
10/01/2003 - "[Study on gamma-synuclein gene in patients with idiopathic Parkinson's disease]."
08/01/2009 - "Although beta-syn is a neuroprotective molecule counteracting the alpha-syn pathology in tg mice, it was previously shown that both beta-syn and gamma-synuclein were associated with axonal pathology in the hippocampus of sporadic cases of Parkinson's disease and DLB. "
10/01/2003 - "To evaluate the relationship between idiopathic Parkinson's disease (PD) and two polymorphisms (C243G and A377T) of the gamma-synuclein gene in a Chinese Han population of Shanghai area. "
09/14/2001 - "Evaluation of the gamma-synuclein gene in German Parkinson's disease patients."
01/04/1999 - "No pathogenic mutations in the persyn gene in Parkinson's disease."
06/10/2011 - "These observations suggest that overexpression of gamma-synuclein may reduce cell chemo-sensitivity of tumor cells through decreasing microtubule rigidity. "
06/10/2011 - "Using cancer cell lysate, gamma-synuclein protein was found to be localized in both cytosolic compartment and extracted cytoskeleton portion. "
06/10/2011 - "The close association between gamma-synuclein expression and cancer spreading has been demonstrated in a broad range of malignancies. "
01/01/2011 - "Except as a marker of cancer progression, gamma-synuclein (GSyn) had received little attention. "
10/28/2009 - "The expression pattern of gamma-synuclein was determined in 54 CRC tissues and 30 tumor-matched nonneoplastic adjacent tissues (NNAT) 5 cm away from the tumor via real-time quantitative reverse transcription PCR (RT-PCR) and immunohistochemistry. "
|4.||Breast Neoplasms (Breast Cancer)
02/01/2011 - "Insight into residues involved in the structure and function of the breast cancer associated protein human gamma synuclein."
03/01/2009 - "The up-regulation of gamma-synuclein expression by endoplasmic reticulum stress is mediated, at least in part, by activation transcription factor (ATF) 4. Knockdown of gamma-synuclein sensitized human breast cancer cells to endoplasmic reticulum stress-induced apoptosis. "
03/01/2009 - "Overexpression of gamma-synuclein in human breast cancer cells leads to an increase in cell motility, resistance to chemotherapeutic drugs, and mitotic checkpoint dysfunction. "
07/01/2006 - "Expression of breast cancer specific gene-1 (BCSG-1/gamma-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer."
09/01/2003 - "Stage-specific expression of breast cancer-specific gene gamma-synuclein."
|5.||Alzheimer Disease (Alzheimer's Disease)
07/01/2001 - "In Alzheimer's disease patients, immunohistochemical staining for gamma-synuclein revealed the loss of immunoreactivity in the nerve fiber layer and the nerve fiber layer and the appearance of immunopositive cells in or near the outer nuclear layer. "
09/28/2001 - "The main objective of this study was to determine if levels of alpha-, beta- and/or gamma-synuclein mRNAs are differentially affected in brains of Lewy body disease (LBD) and Alzheimer's disease (AD) patients, compared to controls. "
07/01/2001 - "We conclude that, in mature eyes, synucleins are present predominantly in the retina and optic nerve, and the immunoreactivity of gamma-synuclein changes specifically in the retina of Alzheimer's disease patients. "
05/01/2009 - "Furthermore, gamma-synuclein is believed to have a role in certain neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. "
05/01/2000 - "alpha-, beta-, and gamma-Synuclein, a novel family of neuronal proteins, has become the focus of research interest because alpha-synuclein has been increasingly implicated in the pathogenesis of Parkinson's and Alzheimer's disease. "
|2.||Proteins (Proteins, Gene)
|3.||Staphylococcal Protein A (A, Protein)
|5.||Janus Kinase 1
|6.||Glial Cell Line-Derived Neurotrophic Factor (GDNF)
|9.||Fibroblast Growth Factor 1 (FGF-1)
|10.||Choline O-Acetyltransferase (Choline Acetyltransferase)
|1.||Drug Therapy (Chemotherapy)