Y-Box-Binding Protein 1

A CCAAT-enhancer-binding protein that was originally identified as interacting with Y-box PROMOTER REGIONS of MHC CLASS II GENES. It is a highly conserved transcription factor that regulates expression of a wide variety of GENES.

Also Known As:

DNA Binding Protein B; NSEP1 Transcription Factor; Nuclease Sensitive Element Binding Protein 1; Y-Box Binding Protein YB-1; Y-Box Protein-1; Transcription Factor, NSEP1; Y Box Binding Protein 1; Y Box Binding Protein YB 1; Y Box Protein 1

Networked: 160 relevant articles (0 outcomes, 11 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843

Experts

1.	Mertens, Peter R: 10 articles (10/2020 - 09/2002)
2.	Dunn, Sandra E: 6 articles (01/2018 - 06/2005)
3.	Lindquist, Jonathan A: 5 articles (10/2020 - 01/2014)
4.	Matsumoto, Ken: 5 articles (03/2015 - 03/2005)
5.	Bay, Boon-Huat: 5 articles (02/2012 - 03/2005)
6.	Wang, Yong: 4 articles (11/2021 - 02/2015)
7.	Yue, Dan: 4 articles (11/2021 - 02/2015)
8.	Hartley, Antja-Voy: 4 articles (01/2020 - 09/2015)
9.	Lu, Tao: 4 articles (01/2020 - 09/2015)
10.	Raffetseder, Ute: 4 articles (01/2020 - 06/2012)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - "MiR-137 plays a tumor suppressor role in other cancers, so the aim of this study was to characterize it and its target Y-box binding protein 1 (YBX1) in MPM. " 07/28/2021 - "Y-box binding protein 1 (YB-1) is closely correlated with tumors and drug resistance. " 01/01/2021 - "Potential Therapeutic Strategies for Targeting Y-Box-Binding Protein 1 in Cancers." 10/01/2020 - "The importance of cold-shock Y-box binding protein 1 (YB-1) for cell homeostasis is well-documented based on prior observations of its association with certain cancer entities. " 01/29/2020 - "Elevated levels of nuclear Y-box binding protein 1 (YB-1) are linked to poor prognosis in cancer. "
2.	Breast Neoplasms (Breast Cancer) 02/01/2012 - "The purpose of this study was to investigate the expression of Y-Box-binding protein 1 (YB-1) in breast cancer and its correlation with clinicopathological characteristics and prognosis. " 08/01/2018 - "Cell viability, cell apoptosis, cell cycle, intracellular drug accumulation, the expression of P-gp and Y-box binding protein 1 (YB-1), and breast cancer stem cells (BCSCs) were then assessed. " 01/01/2018 - "Cytoplasmic localization of the oncogenic transcription and translation factor Y-box binding protein 1 (YB-1) is a powerful inducer of EMT in breast carcinoma cells. " 09/01/2016 - "The value of cytoplasmic Y-box-binding protein 1 as a prognostic marker for breast cancer in Korean." 09/30/2014 - "To explore the roles of Y box-binding protein 1 (YB-1) in breast cancer cell proliferation. "
3.	Ovarian Neoplasms (Ovarian Cancer) 04/26/2007 - "Akt-dependent nuclear localization of Y-box-binding protein 1 in acquisition of malignant characteristics by human ovarian cancer cells." 01/01/2021 - "Y box binding protein 1 inhibition as a targeted therapy for ovarian cancer." 01/01/2016 - "Y-box protein-1/p18 as novel serum marker for ovarian cancer diagnosis: A study by the Tumor Bank Ovarian Cancer (TOC)."
4.	Lung Neoplasms (Lung Cancer) 11/23/2018 - "In this study, we found that LINC00312 induced migration, invasion and VM of lung cancer cells by direct binding to the transcription factor Y-Box Binding Protein 1 (YBX1). " 09/13/2016 - "CAR10 bound and stabilized transcription factor Y-box-binding protein 1 (YB-1), leading to up-regulation of the epidermal growth factor receptor (EGFR) and proliferation of lung cancer cells. " 06/01/2016 - "Silencing Y-box binding protein 1 (YB-1) can be an excellent target for cancer therapy and many lung cancer cells express the polysaccharide-recognition receptor Dectin-1. "
5.	Fibrosis (Cirrhosis) 12/01/2016 - "In vitro, Y-box protein-1 (YB-1) acts as a central regulator of gene transcription and translation of several fibrosis-related genes. " 11/01/2009 - "The present study was undertaken to investigate the ability of HSc025, a novel small compound that antagonizes TGFbeta/Smad signaling through the activation of nuclear translocation of Y-box binding protein 1, to prevent tissue fibrosis in vitro or in mouse models of SSc. " 01/01/2022 - "For example, human antigen R has been reported to have a renoprotective function in acute kidney injury (AKI) but might also contribute to the development of glomerulosclerosis, tubulointerstitial fibrosis and diabetic kidney disease (DKD), loss of bicaudal C is associated with cystic kidney diseases and Y-box binding protein 1 has been implicated in the pathogenesis of AKI, DKD and glomerular disorders. "

Related Drugs and Biologics

1.	Transcription Factors (Transcription Factor)
2.	Biomarkers (Surrogate Marker)
3.	Cyclins
4.	Transforming Growth Factor beta (TGF-beta)
5.	Antigens
6.	Serum Response Factor
7.	Complementary DNA (cDNA)
8.	Paraffin
9.	Celecoxib (Celebrex)
10.	HSc025

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Adjuvant Chemotherapy
4.	Sutures (Suture)
5.	Ligation