COUP Transcription Factors
A sub-family of steroid receptor-related orphan nuclear receptors that have specificity for a variety of DNA sequences related to AGGTCA. COUP transcription factors can heterodimerize with a variety of factors including RETINOIC ACID RECEPTORS; THYROID HORMONE RECEPTORS; and VITAMIN D RECEPTORS.
Also Known As:
COUP-TF Proteins; Chicken Ovalbumin Upstream Promoter-Transcription Factors; COUP TF Proteins; Chicken Ovalbumin Upstream Promoter Transcription Factors; Transcription Factors, COUP
Networked: 4
relevant articles (0 outcomes,
0 trials/studies)
Bio-Agent Context: Research Results
Experts
1. | Grafer, Constance M:
1 article
(03/2015)
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2. | Halvorson, Lisa M:
1 article
(03/2015)
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3. | Kim, Jonathan:
1 article
(03/2015)
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4. | Zheng, Weiming:
1 article
(03/2015)
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5. | Butler, Miriam S:
1 article
(12/2014)
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6. | Cherkasov, Artem:
1 article
(12/2014)
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7. | Hsing, Michael:
1 article
(12/2014)
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8. | Rennie, Paul S:
1 article
(12/2014)
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9. | Roshan-Moniri, Mani:
1 article
(12/2014)
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10. | Clarke, Robert:
1 article
(09/2010)
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Related Diseases
1. | Dosage-sensitive sex reversal
01/01/2004
- " In particular, gene-silencing events elicited by chicken ovalbumin upstream promoter-transcription factors (COUP-TFs); dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX-1); germ cell nuclear factor (GCNF); short heterodimer partner (SHP); and testicular receptors 2 and 4 (TR2 and TR4) are among the best characterized. " 03/01/2015
- " A number of orphan nuclear receptors including steroidogenic factor 1, liver receptor homologue 1, dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1, and chicken ovalbumin upstream promoter-transcription factors I/II as well as the GATA family members, GATA2 and GATA4, have also been implicated in transcriptional regulation of the gonadotropin genes. "
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2. | Neoplasms (Cancer)
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3. | Breast Neoplasms (Breast Cancer)
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Related Drugs and Biologics
Related Therapies and Procedures