Lymphoid Enhancer-Binding Factor 1

A T-cell factor that plays an essential role in EMBRYONIC DEVELOPMENT.

Also Known As:

LEF-1 Transcription Factor; T Cell-Specific Transcription Factor 1-alpha; LEF 1 Transcription Factor; Lymphoid Enhancer Binding Factor 1; T Cell Specific Transcription Factor 1 alpha; Transcription Factor, LEF-1

Networked: 66 relevant articles (0 outcomes, 9 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843

Experts

1.	Liu, Yuting: 3 articles (02/2020 - 12/2011)
2.	Shang, Donghao: 3 articles (02/2020 - 12/2011)
3.	Chen, Yuheng: 2 articles (05/2021 - 12/2020)
4.	Gao, Shou-Jiang: 2 articles (05/2021 - 12/2020)
5.	Li, Wan: 2 articles (05/2021 - 12/2020)
6.	Lu, Chun: 2 articles (05/2021 - 12/2020)
7.	Lu, Hongmei: 2 articles (05/2021 - 12/2020)
8.	Lu, Yao: 2 articles (05/2021 - 12/2020)
9.	Lu, Zhongmou: 2 articles (05/2021 - 12/2020)
10.	Qi, Xiaoyu: 2 articles (05/2021 - 12/2020)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2014 - "Overexpression of lymphoid enhancer-binding factor 1 (LEF1) in solid-pseudopapillary neoplasms of the pancreas." 11/01/2020 - "Lymphoid Enhancer Binding Factor 1 (LEF1) and Paired Box Gene 8 (PAX8): A Limited Immunohistochemistry Panel to Distinguish Solid Pseudopapillary Neoplasms and Pancreatic Neuroendocrine Tumors." 01/01/2020 - "Previously published studies have indicated that lymphoid enhancer-binding factor 1 (LEF1) expression could be recognized as a valuable biomarker to evaluate clinical outcome for various types of malignant cancer, but the results remained controversial. " 11/01/2019 - "The usefulness of lymphoid enhancer-binding factor 1 and androgen receptor in diagnosing solid pseudopapillary neoplasm of the pancreas on cytopathology." 05/01/2018 - "Lymphoid enhancer-binding factor 1 (LEF-1) is a downstream component of this pathway, and Caudal-related homeobox transcription factor 2 (CDX2) has been postulated to regulate it, but little is known about expression of these transcription factors in pilomatrical tumors. "
2.	Esophageal Squamous Cell Carcinoma 01/01/2020 - "Our previous study demonstrated that lymphoid enhancer-binding factor 1 (LEF1) could promote the progression of esophageal squamous cell carcinoma (ESCC). " 01/01/2020 - "Background: Our previous studies reported that lymphoid enhancer-binding factor 1 (LEF1) was upregulated in esophageal squamous cell carcinoma (ESCC) and the positive expression of LEF1 was correlated with aberrant clinicopathological characteristics in ESCC patients. "
3.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 06/01/2021 - "Downregulation of Lymphoid enhancer-binding factor 1 (LEF-1) expression (by immunohistochemistry and/ flow cytometry) in chronic Lymphocytic Leukemia with atypical immunophenotypic and cytologic features." 02/01/2015 - "Flow cytometric analysis of lymphoid enhancer-binding factor 1 in diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma." 03/01/2017 - "Recent studies have shown that lymphoid enhancer binding factor 1 (LEF1) is a useful marker for chronic lymphocytic B-cell leukemia (CLL)/small lymphocytic lymphoma. " 06/01/2021 - "Lymphoid enhancer-binding factor 1 (LEF-1) overexpression has been recently remarkably reported in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and has shown utility in distinguishing CLL/SLL from other B-cell lymphomas. " 12/01/2020 - "Lymphoid enhancer binding factor 1 (LEF1) is consistently upregulated in chronic lymphocytic leukemia (CLL) and in a subset of large B cell lymphoma. "
4.	Pilomatrixoma 06/01/2012 - "In this study, we evaluated histological and molecular features of a bullous pilomatricoma along with 5 control tumors and determined that tumors of both anetodermic and control pilomatricoma comprise similar molecular features, such as nuclear lymphoid enhancer binding factor 1 (LEF1) localization and the expression of keratins. "
5.	B-Cell Leukemia (Leukemia, B Cell) 03/01/2017 - "Recent studies have shown that lymphoid enhancer binding factor 1 (LEF1) is a useful marker for chronic lymphocytic B-cell leukemia (CLL)/small lymphocytic lymphoma. "

Related Drugs and Biologics

1.	Androgen Receptors (Androgen Receptor)
2.	Transcription Factors (Transcription Factor)
3.	Catenins
4.	beta Catenin
5.	Long Noncoding RNA
6.	Antisense RNA (Anti-Sense RNA)
7.	Biomarkers (Surrogate Marker)
8.	Tetraspanins
9.	Proteome
10.	Keratins (Keratin)

Related Therapies and Procedures

1.	Immunotherapy