Immunoglobulin J Recombination Signal Sequence-Binding Protein

A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS.

Also Known As:

C-Promotor-Binding Factor 1; RBP-Jkappa Protein; Recombination Binding Protein J; C Promotor Binding Factor 1; Immunoglobulin J Recombination Signal Sequence Binding Protein; RBP Jkappa Protein; Ig J Recombination Signal Sequence Binding Protein

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Fibrosarcoma 07/01/1997 - "A reporter gene study was performed to determine the functional implication of this binding; we found that the constitutive occupancy of the IL6-kappaB site by the RBP-Jkappa protein was responsible for the low basal levels of IL-6 promoter activity in L929sA fibrosarcoma cells and that RBP-Jkappa partially blocked access of NF-kappaB complexes to the IL-6 promoter. "

Related Drugs and Biologics

1.	NF-kappa B (NF-kB)
2.	Interleukin-6 (Interleukin 6)