Inhibitor of Differentiation Proteins

Inhibitor of differentiation proteins are negative regulators of BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS. They inhibit CELL DIFFERENTIATION and induce CELL PROLIFERATION by modulating different CELL CYCLE regulators.

Also Known As:

ID DNA Binding Protein Inhibitor; Differentiation Proteins Inhibitor; Inhibitor Of Differentiation Protein

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Inhibitor of Differentiation Proteins: 6

Experts

1.	Bajbouj, Khuloud: 1 article (12/2021)
2.	Dhaiban, Sarah: 1 article (12/2021)
3.	Hachim, Mahmood Y: 1 article (12/2021)
4.	Hamad, Mawieh: 1 article (12/2021)
5.	Khalique, Anila: 1 article (12/2021)
6.	Laham, Amina: 1 article (12/2021)
7.	Mohammed, Abdul Khader: 1 article (12/2021)
8.	Mukhopadhy, Debasmita: 1 article (12/2021)
9.	Taneera, Jalal: 1 article (12/2021)
10.	Dou, Peiyuan: 1 article (11/2021)

Related Diseases

1.	Iron Overload 12/01/2021 - "Heme Oxygenase-1 (HMOX-1) and inhibitor of differentiation proteins (ID1, ID3) are key response mechanisms against iron-overload in pancreatic β-cells."
2.	Lobular Carcinoma 01/01/2020 - "Proteomic and transcriptomic profiling identifies mediators of anchorage-independent growth and roles of inhibitor of differentiation proteins in invasive lobular carcinoma."
3.	Neoplasms (Cancer) 10/01/2013 - "Inhibitor of differentiation proteins (Id1, 2, 3 and 4) are dominant negative regulators of basic helix loop helix transcription factors and play dominant roles in cancer cells, spanning several molecular pathways including senescence, invasion, metastasis, proliferation and apoptosis. "
4.	Neoplasm Metastasis (Metastasis) 10/01/2013 - "Inhibitor of differentiation proteins (Id1, 2, 3 and 4) are dominant negative regulators of basic helix loop helix transcription factors and play dominant roles in cancer cells, spanning several molecular pathways including senescence, invasion, metastasis, proliferation and apoptosis. "
5.	Glioma (Gliomas) 11/01/2021 - "Serving as an inhibitor of differentiation, protein ID2 (inhibitor of DNA binding 2) plays an important role in neurogenesis, neovascularization and malignant development of gliomas. "

Related Drugs and Biologics

1.	Basic Helix-Loop-Helix Transcription Factors
2.	Heme Oxygenase-1
3.	DNA (Deoxyribonucleic Acid)