Basic Helix-Loop-Helix Transcription Factors

A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.

Also Known As:

bHLH Proteins; bHLH Transcription Factors; Basic Helix Loop Helix Transcription Factor; Basic Helix Loop Helix Transcription Factors; Factor, bHLH Transcription; Protein, bHLH; Transcription Factor, bHLH; Transcription Factors, bHLH; Basic Helix-Loop-Helix Transcription Factor; bHLH Protein; bHLH Transcription Factor

Networked: 510 relevant articles (3 outcomes, 42 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Basic Helix-Loop-Helix Transcription Factors: 510
  - DNA-Binding Proteins: 2009
    - Basic Helix-Loop-Helix Transcription Factors: 510

Experts

1.	Kato, Yukio: 12 articles (07/2018 - 12/2002)
2.	Kijima, Hiroshi: 11 articles (01/2017 - 02/2008)
3.	Sato, Fuyuki: 10 articles (11/2020 - 02/2008)
4.	Kawamoto, Takeshi: 10 articles (07/2018 - 12/2002)
5.	Wu, Yunyan: 10 articles (01/2017 - 04/2010)
6.	Fujimoto, Katsumi: 9 articles (07/2018 - 02/2008)
7.	Morohashi, Satoko: 9 articles (01/2017 - 04/2010)
8.	Good, Deborah J: 7 articles (01/2020 - 11/2002)
9.	Noshiro, Mitsuhide: 7 articles (07/2018 - 02/2008)
10.	Seino, Hiroko: 7 articles (01/2017 - 04/2012)

Related Diseases

1.	Neoplasms (Cancer) 01/26/2015 - "In this issue of Developmental Cell, Wang and Baker (2015) demonstrate unsuspected cross-talk between bHLH transcription factors, important regulators of organogenesis, with the Hippo tumor suppressor pathway to ensure that inappropriately differentiating cells are eliminated during development. " 01/01/2020 - "Previous studies have shown that a novel tumor oncogene, spermatogenic basic helix-loop-helix transcription factor zip 1 (SPZ1), can promote proliferation. " 04/01/2018 - "Previous studies have determined that the basic helix-loop-helix transcription factor achaete-scute homolog 1 (ASCL1) is essential for the survival and progression of a fraction of pulmonary neuroendocrine cancer cells, which include both SCLC and a subset of non-SCLC. " 01/01/2017 - "Recently, some studies identified the Basic-Helix-Loop-Helix (bHLH) transcription factor as a significant regulator for the evolution of neoplasms. " 05/01/2014 - "This study establishes a unique model in which determinants of CNS tumor diversity can be parsed out and reveals that both mutation and expression of neurogenic bHLH transcription factors contribute to CNS tumor diversity. "
2.	Carcinogenesis 03/01/2021 - "Twist, a basic helix-loop-helix (bHLH) transcription factor, is an epithelial-mesenchymal transition ((EMT) inducer that has been involved in carcinogenesis and chemoresistance. " 01/01/2021 - "Role of the bHLH transcription factor TCF21 in development and tumorigenesis." 09/01/2020 - "Atonal bHLH transcription factor 1 is an important factor for maintaining the balance of cell proliferation and differentiation in tumorigenesis." 03/01/2020 - "The Twist basic helix-loop-helix transcription factor 1 (Twist1) has been implicated in embryogenesis and carcinogenesis, due to its effects on cell proliferation and anti-apoptosis signaling. " 01/01/2019 - "Aberrant expression of bhlh transcription factors has been shown to be associated with multiple tumorigenesis. "
3.	Atherosclerosis 11/05/2019 - "TFEB is a basic helix-loop-helix transcription factor that confers protection against metabolic diseases such as atherosclerosis by targeting a network of genes involved in autophagy-lysosomal biogenesis and lipid catabolism. "
4.	Metabolic Diseases (Metabolic Disease) 11/05/2019 - "TFEB is a basic helix-loop-helix transcription factor that confers protection against metabolic diseases such as atherosclerosis by targeting a network of genes involved in autophagy-lysosomal biogenesis and lipid catabolism. "
5.	Hypoxia (Hypoxemia) 01/01/2020 - "In the present study, we detected the role of the spermatogenesis- and oogenesis-specific basic helix-loop-helix (bHLH) transcription factor 2 (sohlh2) on migration, invasion and epithelial-mesenchymal transition (EMT) of EOC cell lines under hypoxia in vitro. " 12/01/2003 - "Previous studies have revealed the essential role of hypoxia-inducible factor-1alpha (HIF-1alpha), a basic helix-loop-helix transcription factor, in cardiovascular development. " 04/01/2017 - "Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric basic helix-loop-helix transcription factor composed of the HIF-1α and HIF-1β subunits. " 01/01/2017 - "The functions of differentiated embryonic chondrocyte gene (DEC) 1, a basic helix-loop-helix (bHLH) transcription factor, have been reported to be associated with the regulation of mammalian circadian rhythms, differentiation of chondrocytes and skeletal muscles, apoptosis, hypoxia-induced reactions and epithelial mesenchymal transition. " 10/01/2012 - "DEC1 (BHLHE40/Stra13/Sharp2) is a basic helix-loop-helix (bHLH) transcription factor that is involved in the regulation of apoptosis and cell proliferation and the response to hypoxia. "

Related Drugs and Biologics

1.	Oxidoreductases (Dehydrogenase)
2.	NAD (NADH)
3.	Lipids
4.	quinone (benzoquinone)
5.	Proteins (Proteins, Gene)
6.	Transcription Factors (Transcription Factor)
7.	Transcription Factor 4
8.	Elements
9.	Cadherins (E-Cadherin)
10.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics